Investigating the effectiveness of iron nanoparticles synthesized by green synthesis method in chemoradiotherapy of colon cancer
Current methods of colon cancer treatment, especially chemotherapy, require new treatment methods due to adverse side effects. One important area of interest in recent years is the use of nanoparticles as drug delivery vehicles since several studies have revealed that they can improve the target spe...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024043743 |
| _version_ | 1797247728303996928 |
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| author | Farshad Seyed Nejad Mostafa Alizade-Harakiyan Mehdi Haghi Rokhsareh Ebrahimi Mohammad Mahdi Zangeneh Alireza Farajollahi Roghayeh Fathi Reza Mohammadi Samira Samadi Miandoab Mohammad Heydarnezhad Asl Parina Asgharian Baharak Divband Amin Ahmadi |
| author_facet | Farshad Seyed Nejad Mostafa Alizade-Harakiyan Mehdi Haghi Rokhsareh Ebrahimi Mohammad Mahdi Zangeneh Alireza Farajollahi Roghayeh Fathi Reza Mohammadi Samira Samadi Miandoab Mohammad Heydarnezhad Asl Parina Asgharian Baharak Divband Amin Ahmadi |
| author_sort | Farshad Seyed Nejad |
| collection | DOAJ |
| description | Current methods of colon cancer treatment, especially chemotherapy, require new treatment methods due to adverse side effects. One important area of interest in recent years is the use of nanoparticles as drug delivery vehicles since several studies have revealed that they can improve the target specificity of the treatment thus lowering the dosage of the drugs while preserving the effectiveness of the treatment thus reducing the side effects. The use of traditional medicine has also been a favorite topic of interest in recent years in medical research, especially cancer research. In this research work, the green synthesis of Fe nanoparticles was carried out using Mentha spicata extract and the synthesized nanoparticles were identified using FT-IR, XRD, FE-SEM and EDS techniques. Then the effect of Mentha spicata, Fe nanoparticles, and Mentha spicata -loaded Fe nanoparticles on LS174t colon cancer cells, and our result concluded that all three, especially Mentha spicata -loaded Fe nanoparticles, have great cytotoxic effects against LS174t cells, and exposure to radiotherapy just further intensified these results. The in vitro condition revealed alterations in the expression of pro-apoptotic BAX and anti-apoptotic Bcl2, suggesting a pro-apoptotic effect from all three components, particularly the Mentha spicata-loaded Fe nanoparticles. After further clinical trials, these nanoparticles can be used to treat colon cancer. |
| first_indexed | 2024-04-24T20:03:18Z |
| format | Article |
| id | doaj.art-3e3bfc4090cd49beadae72570738df92 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T20:03:18Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-3e3bfc4090cd49beadae72570738df922024-03-24T06:59:43ZengElsevierHeliyon2405-84402024-04-01107e28343Investigating the effectiveness of iron nanoparticles synthesized by green synthesis method in chemoradiotherapy of colon cancerFarshad Seyed Nejad0Mostafa Alizade-Harakiyan1Mehdi Haghi2Rokhsareh Ebrahimi3Mohammad Mahdi Zangeneh4Alireza Farajollahi5Roghayeh Fathi6Reza Mohammadi7Samira Samadi Miandoab8Mohammad Heydarnezhad Asl9Parina Asgharian10Baharak Divband11Amin Ahmadi12Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Radiation Oncology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Radiation Oncology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Medical Physics Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Corresponding author. Department of Radiation Oncology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran; Corresponding author.Medicinal Chemistry Department, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran; Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, IranDepartment of Radiation Oncology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Medical Physics Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Medical Radiation Science Research Team, Tabriz University of Medical Sciences, Tabriz, IranPolymer Research Laboratory, Department of Organic and Biochemistry, University of Tabriz, Tabriz, IranPolymer Research Laboratory, Department of Organic and Biochemistry, University of Tabriz, Tabriz, IranBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, IranDepartment of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Inorganic Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, IranResearch Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, IranCurrent methods of colon cancer treatment, especially chemotherapy, require new treatment methods due to adverse side effects. One important area of interest in recent years is the use of nanoparticles as drug delivery vehicles since several studies have revealed that they can improve the target specificity of the treatment thus lowering the dosage of the drugs while preserving the effectiveness of the treatment thus reducing the side effects. The use of traditional medicine has also been a favorite topic of interest in recent years in medical research, especially cancer research. In this research work, the green synthesis of Fe nanoparticles was carried out using Mentha spicata extract and the synthesized nanoparticles were identified using FT-IR, XRD, FE-SEM and EDS techniques. Then the effect of Mentha spicata, Fe nanoparticles, and Mentha spicata -loaded Fe nanoparticles on LS174t colon cancer cells, and our result concluded that all three, especially Mentha spicata -loaded Fe nanoparticles, have great cytotoxic effects against LS174t cells, and exposure to radiotherapy just further intensified these results. The in vitro condition revealed alterations in the expression of pro-apoptotic BAX and anti-apoptotic Bcl2, suggesting a pro-apoptotic effect from all three components, particularly the Mentha spicata-loaded Fe nanoparticles. After further clinical trials, these nanoparticles can be used to treat colon cancer.http://www.sciencedirect.com/science/article/pii/S2405844024043743Iron nanoparticlesMentha spicata extractColon carcinomaRadiotherapy |
| spellingShingle | Farshad Seyed Nejad Mostafa Alizade-Harakiyan Mehdi Haghi Rokhsareh Ebrahimi Mohammad Mahdi Zangeneh Alireza Farajollahi Roghayeh Fathi Reza Mohammadi Samira Samadi Miandoab Mohammad Heydarnezhad Asl Parina Asgharian Baharak Divband Amin Ahmadi Investigating the effectiveness of iron nanoparticles synthesized by green synthesis method in chemoradiotherapy of colon cancer Heliyon Iron nanoparticles Mentha spicata extract Colon carcinoma Radiotherapy |
| title | Investigating the effectiveness of iron nanoparticles synthesized by green synthesis method in chemoradiotherapy of colon cancer |
| title_full | Investigating the effectiveness of iron nanoparticles synthesized by green synthesis method in chemoradiotherapy of colon cancer |
| title_fullStr | Investigating the effectiveness of iron nanoparticles synthesized by green synthesis method in chemoradiotherapy of colon cancer |
| title_full_unstemmed | Investigating the effectiveness of iron nanoparticles synthesized by green synthesis method in chemoradiotherapy of colon cancer |
| title_short | Investigating the effectiveness of iron nanoparticles synthesized by green synthesis method in chemoradiotherapy of colon cancer |
| title_sort | investigating the effectiveness of iron nanoparticles synthesized by green synthesis method in chemoradiotherapy of colon cancer |
| topic | Iron nanoparticles Mentha spicata extract Colon carcinoma Radiotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024043743 |
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