Systematic Review of the Treatment of Persistent Hyperparathyroidism Following Kidney Transplantation
Chronic kidney disease–mineral and bone disorder is one of the complications associated with chronic kidney disease. About 10–50% of patients following kidney transplantation have persistent hyperparathyroidism. Hypercalcaemic hyperparathyroidism has a negative impact on the kidney transplant outcom...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/1/25 |
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| author | Miłosz Miedziaszczyk Katarzyna Lacka Oskar Tomczak Aleksander Bajon Marta Primke Ilona Idasiak-Piechocka |
| author_facet | Miłosz Miedziaszczyk Katarzyna Lacka Oskar Tomczak Aleksander Bajon Marta Primke Ilona Idasiak-Piechocka |
| author_sort | Miłosz Miedziaszczyk |
| collection | DOAJ |
| description | Chronic kidney disease–mineral and bone disorder is one of the complications associated with chronic kidney disease. About 10–50% of patients following kidney transplantation have persistent hyperparathyroidism. Hypercalcaemic hyperparathyroidism has a negative impact on the kidney transplant outcome; therefore, it requires treatment. The data regarding the treatment of persistent hyperparathyroidism provided in scientific publications are divergent and contradictory. Therefore, the aim of our systematic review was to evaluate the efficacy of persistent hyperparathyroidism treatment in patients following kidney transplantation. The Cochrane, PubMed, and Scopus databases were browsed independently by two authors. The search strategy included controlled vocabulary and keywords. The effectiveness of calcitriol, paricalcitol, cinacalcet, and parathyroidectomy was compared and analysed. The mean calcium and parathormone (PTH) concentrations per patient in the group of paricalcitol increased by 1.27% and decreased by 35.14% (n = 248); in the group of cinacalcet decreased by 12.09% and 32.16% (n = 368); and in the group of parathyroidectomy decreased by 19.06% and 86.49% (n = 15) at the end of the study compared to the baseline (n = 244, n = 342 and n = 15), respectively. Paricalcitol, cinacalcet, and parathyroidectomy decreased the intact PTH level. Cinacalcet and parathyroidectomy lowered calcium levels in renal transplant patients with hypercalcaemia. Conversely, paricalcitol increased the serum calcium concentration. Cinacalcet seems to be a good candidate in the treatment of post-transplant hyperparathyroidism. |
| first_indexed | 2024-03-09T13:30:59Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T13:30:59Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-3e3bffe9aca247a19d0fae402bc5355e2023-11-30T21:18:20ZengMDPI AGBiomedicines2227-90592022-12-011112510.3390/biomedicines11010025Systematic Review of the Treatment of Persistent Hyperparathyroidism Following Kidney TransplantationMiłosz Miedziaszczyk0Katarzyna Lacka1Oskar Tomczak2Aleksander Bajon3Marta Primke4Ilona Idasiak-Piechocka5Department of Nephrology, Transplantology and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, PolandDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland1st Department of Anesthesiology and Intensive Therapy, Poznan University of Medical Sciences, 61-848 Poznan, PolandStudent Scientific Section of Department of Nephrology, Transplantology and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, PolandStudent’s Scientific Section of Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, PolandDepartment of Nephrology, Transplantology and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, PolandChronic kidney disease–mineral and bone disorder is one of the complications associated with chronic kidney disease. About 10–50% of patients following kidney transplantation have persistent hyperparathyroidism. Hypercalcaemic hyperparathyroidism has a negative impact on the kidney transplant outcome; therefore, it requires treatment. The data regarding the treatment of persistent hyperparathyroidism provided in scientific publications are divergent and contradictory. Therefore, the aim of our systematic review was to evaluate the efficacy of persistent hyperparathyroidism treatment in patients following kidney transplantation. The Cochrane, PubMed, and Scopus databases were browsed independently by two authors. The search strategy included controlled vocabulary and keywords. The effectiveness of calcitriol, paricalcitol, cinacalcet, and parathyroidectomy was compared and analysed. The mean calcium and parathormone (PTH) concentrations per patient in the group of paricalcitol increased by 1.27% and decreased by 35.14% (n = 248); in the group of cinacalcet decreased by 12.09% and 32.16% (n = 368); and in the group of parathyroidectomy decreased by 19.06% and 86.49% (n = 15) at the end of the study compared to the baseline (n = 244, n = 342 and n = 15), respectively. Paricalcitol, cinacalcet, and parathyroidectomy decreased the intact PTH level. Cinacalcet and parathyroidectomy lowered calcium levels in renal transplant patients with hypercalcaemia. Conversely, paricalcitol increased the serum calcium concentration. Cinacalcet seems to be a good candidate in the treatment of post-transplant hyperparathyroidism.https://www.mdpi.com/2227-9059/11/1/25persistent hyperparathyroidismkidney transplantationrenal transplantationtreatmentsystematic review |
| spellingShingle | Miłosz Miedziaszczyk Katarzyna Lacka Oskar Tomczak Aleksander Bajon Marta Primke Ilona Idasiak-Piechocka Systematic Review of the Treatment of Persistent Hyperparathyroidism Following Kidney Transplantation Biomedicines persistent hyperparathyroidism kidney transplantation renal transplantation treatment systematic review |
| title | Systematic Review of the Treatment of Persistent Hyperparathyroidism Following Kidney Transplantation |
| title_full | Systematic Review of the Treatment of Persistent Hyperparathyroidism Following Kidney Transplantation |
| title_fullStr | Systematic Review of the Treatment of Persistent Hyperparathyroidism Following Kidney Transplantation |
| title_full_unstemmed | Systematic Review of the Treatment of Persistent Hyperparathyroidism Following Kidney Transplantation |
| title_short | Systematic Review of the Treatment of Persistent Hyperparathyroidism Following Kidney Transplantation |
| title_sort | systematic review of the treatment of persistent hyperparathyroidism following kidney transplantation |
| topic | persistent hyperparathyroidism kidney transplantation renal transplantation treatment systematic review |
| url | https://www.mdpi.com/2227-9059/11/1/25 |
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