The role of the neural crest in the normal and abnormal heart development
The data about participation of the neural crest in the normal and abnormal cardiogenesis are summarized in the review. The main morphological phenomena which accompany the interaction of the neural crest cells and embryonic heart are the migration of the dense mesenchyme originated from neural cres...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy
2007-01-01
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| Series: | Морфологія |
| Subjects: | |
| Online Access: | http://www.morphology.dp.ua/_pub/MORPHO-2007-01-02/07mmatak.pdf |
| _version_ | 1818028858489700352 |
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| author | Mashtalir M.A. Tverdokhleb I.V. Kozlov V.A. |
| author_facet | Mashtalir M.A. Tverdokhleb I.V. Kozlov V.A. |
| author_sort | Mashtalir M.A. |
| collection | DOAJ |
| description | The data about participation of the neural crest in the normal and abnormal cardiogenesis are summarized in the review. The main morphological phenomena which accompany the interaction of the neural crest cells and embryonic heart are the migration of the dense mesenchyme originated from neural crest from pharyngeal arches to the trunk of heart as well as apoptotic processes. After chemical teratogens treatment such as retinoic acid and ethyl alcohol the distant relationship between neural crest and heart and also the migration of neural crest cells to the heart were changed. The decrease of inten-sity of the apoptotic processes in the heart, the delay of reduction of the conotruncal and atrioventricular myocardium and lesion of mesenchyme structures were determined morphologically. The ethanol and retinoic acid treatment cause also the abnormalities in the interventricular foramen closure, in the development of conductive system, and heart valves. We suggest that these abnormalities are mediated by the neural crest cells. |
| first_indexed | 2024-12-10T05:10:28Z |
| format | Article |
| id | doaj.art-3e3d6f76f39e4685a89b5533e26e32cb |
| institution | Directory Open Access Journal |
| issn | 1997-9665 |
| language | Russian |
| last_indexed | 2024-12-10T05:10:28Z |
| publishDate | 2007-01-01 |
| publisher | Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy |
| record_format | Article |
| series | Морфологія |
| spelling | doaj.art-3e3d6f76f39e4685a89b5533e26e32cb2022-12-22T02:01:07ZrusMinistry of Health of Ukraine. Dnipropetrovsk Medical AcademyМорфологія1997-96652007-01-0112411The role of the neural crest in the normal and abnormal heart developmentMashtalir M.A.Tverdokhleb I.V.Kozlov V.A.The data about participation of the neural crest in the normal and abnormal cardiogenesis are summarized in the review. The main morphological phenomena which accompany the interaction of the neural crest cells and embryonic heart are the migration of the dense mesenchyme originated from neural crest from pharyngeal arches to the trunk of heart as well as apoptotic processes. After chemical teratogens treatment such as retinoic acid and ethyl alcohol the distant relationship between neural crest and heart and also the migration of neural crest cells to the heart were changed. The decrease of inten-sity of the apoptotic processes in the heart, the delay of reduction of the conotruncal and atrioventricular myocardium and lesion of mesenchyme structures were determined morphologically. The ethanol and retinoic acid treatment cause also the abnormalities in the interventricular foramen closure, in the development of conductive system, and heart valves. We suggest that these abnormalities are mediated by the neural crest cells.http://www.morphology.dp.ua/_pub/MORPHO-2007-01-02/07mmatak.pdfheartneural crestretinoic acidethanolabnomal development |
| spellingShingle | Mashtalir M.A. Tverdokhleb I.V. Kozlov V.A. The role of the neural crest in the normal and abnormal heart development Морфологія heart neural crest retinoic acid ethanol abnomal development |
| title | The role of the neural crest in the normal and abnormal heart development |
| title_full | The role of the neural crest in the normal and abnormal heart development |
| title_fullStr | The role of the neural crest in the normal and abnormal heart development |
| title_full_unstemmed | The role of the neural crest in the normal and abnormal heart development |
| title_short | The role of the neural crest in the normal and abnormal heart development |
| title_sort | role of the neural crest in the normal and abnormal heart development |
| topic | heart neural crest retinoic acid ethanol abnomal development |
| url | http://www.morphology.dp.ua/_pub/MORPHO-2007-01-02/07mmatak.pdf |
| work_keys_str_mv | AT mashtalirma theroleoftheneuralcrestinthenormalandabnormalheartdevelopment AT tverdokhlebiv theroleoftheneuralcrestinthenormalandabnormalheartdevelopment AT kozlovva theroleoftheneuralcrestinthenormalandabnormalheartdevelopment AT mashtalirma roleoftheneuralcrestinthenormalandabnormalheartdevelopment AT tverdokhlebiv roleoftheneuralcrestinthenormalandabnormalheartdevelopment AT kozlovva roleoftheneuralcrestinthenormalandabnormalheartdevelopment |