Altered Emotional Phenotypes in Chronic Kidney Disease Following 5/6 Nephrectomy
Increased prevalence of chronic kidney disease (CKD) and neurological disorders including cerebrovascular disease, cognitive impairment, peripheral neuropathy, and dysfunction of central nervous system have been reported during the natural history of CKD. Psychological distress and depression are se...
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MDPI AG
2021-06-01
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| Series: | Brain Sciences |
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| author | Yeon Hee Yu Seong-Wook Kim Dae-Kyoon Park Ho-Yeon Song Duk-Soo Kim Hyo-Wook Gil |
| author_facet | Yeon Hee Yu Seong-Wook Kim Dae-Kyoon Park Ho-Yeon Song Duk-Soo Kim Hyo-Wook Gil |
| author_sort | Yeon Hee Yu |
| collection | DOAJ |
| description | Increased prevalence of chronic kidney disease (CKD) and neurological disorders including cerebrovascular disease, cognitive impairment, peripheral neuropathy, and dysfunction of central nervous system have been reported during the natural history of CKD. Psychological distress and depression are serious concerns in patients with CKD. However, the relevance of CKD due to decline in renal function and the pathophysiology of emotional deterioration is not clear. Male Sprague Dawley rats were divided into three groups: sham control, 5/6 nephrectomy at 4 weeks, and 5/6 nephrectomy at 10 weeks. Behavior tests, local field potentials, and histology and laboratory tests were conducted and investigated. We provided direct evidence showing that CKD rat models exhibited anxiogenic behaviors and depression-like phenotypes, along with altered hippocampal neural oscillations at 1–12 Hz. We generated CKD rat models by performing 5/6 nephrectomy, and identified higher level of serum creatinine and blood urea nitrogen (BUN) in CKD rats than in wild-type, depending on time. In addition, the level of α-smooth muscle actin (α-SMA) and collagen I for renal tissue was markedly elevated, with worsening fibrosis due to renal failures. The level of anxiety and depression-like behaviors increased in the 10-week CKD rat models compared with the 4-week rat models. In the recording of local field potentials, the power of delta (1–4 Hz), theta (4–7 Hz), and alpha rhythm (7–12 Hz) was significantly increased in the hippocampus of CKD rats compared with wild-type rats. Together, our findings indicated that anxiogenic behaviors and depression can be induced by CKD, and these abnormal symptoms can be worsened as the onset of CKD was prolonged. In conclusion, our results show that the hippocampus is vulnerable to uremia. |
| first_indexed | 2024-03-10T09:53:36Z |
| format | Article |
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| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T09:53:36Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-3e3fbe15075f48ab8916bfb8fa3adf3a2023-11-22T02:28:42ZengMDPI AGBrain Sciences2076-34252021-06-0111788210.3390/brainsci11070882Altered Emotional Phenotypes in Chronic Kidney Disease Following 5/6 NephrectomyYeon Hee Yu0Seong-Wook Kim1Dae-Kyoon Park2Ho-Yeon Song3Duk-Soo Kim4Hyo-Wook Gil5Department of Anatomy, College of Medicine, Soonchunhyang University, Cheonan-si 31151, KoreaGraduate School of New Drug Discovery & Development, Chungnam National University, Daejeon 34134, KoreaDepartment of Anatomy, College of Medicine, Soonchunhyang University, Cheonan-si 31151, KoreaDepartment of Microbiology and Immunology, College of Medicine, Soonchunhyang University, Cheonan-si 31151, KoreaDepartment of Anatomy, College of Medicine, Soonchunhyang University, Cheonan-si 31151, KoreaDepartment of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan-si 31151, KoreaIncreased prevalence of chronic kidney disease (CKD) and neurological disorders including cerebrovascular disease, cognitive impairment, peripheral neuropathy, and dysfunction of central nervous system have been reported during the natural history of CKD. Psychological distress and depression are serious concerns in patients with CKD. However, the relevance of CKD due to decline in renal function and the pathophysiology of emotional deterioration is not clear. Male Sprague Dawley rats were divided into three groups: sham control, 5/6 nephrectomy at 4 weeks, and 5/6 nephrectomy at 10 weeks. Behavior tests, local field potentials, and histology and laboratory tests were conducted and investigated. We provided direct evidence showing that CKD rat models exhibited anxiogenic behaviors and depression-like phenotypes, along with altered hippocampal neural oscillations at 1–12 Hz. We generated CKD rat models by performing 5/6 nephrectomy, and identified higher level of serum creatinine and blood urea nitrogen (BUN) in CKD rats than in wild-type, depending on time. In addition, the level of α-smooth muscle actin (α-SMA) and collagen I for renal tissue was markedly elevated, with worsening fibrosis due to renal failures. The level of anxiety and depression-like behaviors increased in the 10-week CKD rat models compared with the 4-week rat models. In the recording of local field potentials, the power of delta (1–4 Hz), theta (4–7 Hz), and alpha rhythm (7–12 Hz) was significantly increased in the hippocampus of CKD rats compared with wild-type rats. Together, our findings indicated that anxiogenic behaviors and depression can be induced by CKD, and these abnormal symptoms can be worsened as the onset of CKD was prolonged. In conclusion, our results show that the hippocampus is vulnerable to uremia.https://www.mdpi.com/2076-3425/11/7/882chronic kidney diseaseemotional phenotypeshippocampusastrogliosisuremiafibrosis |
| spellingShingle | Yeon Hee Yu Seong-Wook Kim Dae-Kyoon Park Ho-Yeon Song Duk-Soo Kim Hyo-Wook Gil Altered Emotional Phenotypes in Chronic Kidney Disease Following 5/6 Nephrectomy Brain Sciences chronic kidney disease emotional phenotypes hippocampus astrogliosis uremia fibrosis |
| title | Altered Emotional Phenotypes in Chronic Kidney Disease Following 5/6 Nephrectomy |
| title_full | Altered Emotional Phenotypes in Chronic Kidney Disease Following 5/6 Nephrectomy |
| title_fullStr | Altered Emotional Phenotypes in Chronic Kidney Disease Following 5/6 Nephrectomy |
| title_full_unstemmed | Altered Emotional Phenotypes in Chronic Kidney Disease Following 5/6 Nephrectomy |
| title_short | Altered Emotional Phenotypes in Chronic Kidney Disease Following 5/6 Nephrectomy |
| title_sort | altered emotional phenotypes in chronic kidney disease following 5 6 nephrectomy |
| topic | chronic kidney disease emotional phenotypes hippocampus astrogliosis uremia fibrosis |
| url | https://www.mdpi.com/2076-3425/11/7/882 |
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