Pregnant and Postpartum Women Requiring Intensive Care Treatment for COVID-19—First Data from the CRONOS-Registry
(1) Background: Data on coronavirus 2 infection during pregnancy vary. We aimed to describe maternal characteristics and clinical presentation of SARS-CoV-2 positive women requiring intensive care treatment for COVID-19 during pregnancy and postpartum period based on data of a comprehensive German s...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/3/701 |
| _version_ | 1797486889928753152 |
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| author | Magdalena Sitter Ulrich Pecks Mario Rüdiger Sabine Friedrich Sara Fill Malfertheiner Alexander Hein Josefine T. Königbauer Karin Becke-Jakob Janine Zöllkau Babett Ramsauer Katharina Rathberger Constanza A. Pontones Katrina Kraft Patrick Meybohm Christoph Härtel Peter Kranke CRONOS Network |
| author_facet | Magdalena Sitter Ulrich Pecks Mario Rüdiger Sabine Friedrich Sara Fill Malfertheiner Alexander Hein Josefine T. Königbauer Karin Becke-Jakob Janine Zöllkau Babett Ramsauer Katharina Rathberger Constanza A. Pontones Katrina Kraft Patrick Meybohm Christoph Härtel Peter Kranke CRONOS Network |
| author_sort | Magdalena Sitter |
| collection | DOAJ |
| description | (1) Background: Data on coronavirus 2 infection during pregnancy vary. We aimed to describe maternal characteristics and clinical presentation of SARS-CoV-2 positive women requiring intensive care treatment for COVID-19 during pregnancy and postpartum period based on data of a comprehensive German surveillance system in obstetric patients. (2) Methods: Data from COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS), a prospective multicenter registry for SARS-CoV-2 positive pregnant women, was analyzed with respect to ICU treatment. All women requiring intensive care treatment for COVID-19 were included and compared regarding maternal characteristics, course of disease, as well as maternal and neonatal outcomes. (3) Results: Of 2650 cases in CRONOS, 101 women (4%) had a documented ICU stay. Median maternal age was 33 (IQR, 30–36) years. COVID-19 was diagnosed at a median gestational age of 33 (IQR, 28–35) weeks. As the most invasive form of COVID-19 treatment interventions, patients received either continuous monitoring of vital signs without further treatment requirement (<i>n</i> = 6), insufflation of oxygen (<i>n</i> = 30), non-invasive ventilation (<i>n</i> = 22), invasive ventilation (<i>n</i> = 28), or escalation to extracorporeal membrane oxygenation (<i>n</i> = 15). No significant clinical differences were identified between patients receiving different forms of ventilatory support for COVID-19. Prevalence of preterm delivery was significantly higher in women receiving invasive respiratory treatments. Four women died of COVID-19 and six fetuses were stillborn. (4) Conclusions: Our cohort shows that progression of COVID-19 is rare in pregnant and postpartum women treated in the ICU. Preterm birth rate is high and COVID-19 requiring respiratory support increases the risk of poor maternal and neonatal outcome. |
| first_indexed | 2024-03-09T23:40:43Z |
| format | Article |
| id | doaj.art-3e41501d8e174e4bb712b559b1a2f080 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:40:43Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3e41501d8e174e4bb712b559b1a2f0802023-11-23T16:52:47ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111370110.3390/jcm11030701Pregnant and Postpartum Women Requiring Intensive Care Treatment for COVID-19—First Data from the CRONOS-RegistryMagdalena Sitter0Ulrich Pecks1Mario Rüdiger2Sabine Friedrich3Sara Fill Malfertheiner4Alexander Hein5Josefine T. Königbauer6Karin Becke-Jakob7Janine Zöllkau8Babett Ramsauer9Katharina Rathberger10Constanza A. Pontones11Katrina Kraft12Patrick Meybohm13Christoph Härtel14Peter Kranke15CRONOS NetworkDepartment of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, 97080 Wuerzburg, GermanyDepartment of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, 24105 Kiel, GermanySaxony Center for Feto-Neonatal Health, Technische Universität Dresden, Medizinische Fakultät, 01307 Dresden, GermanyDepartment of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, 97080 Wuerzburg, GermanyDepartment of Gynecology and Obstetrics, Hospital St. Hedweig of the Order of St. John, University Medical Center Regensburg, 93049 Regensburg, GermanyDepartment of Obstetrics and Gynaecology, Universitätsklinikum Erlangen, 91054 Erlangen, GermanyDepartment of Obstetrics and Gynecology, Vivantes Klinikum im Friedrichshain, 10249 Berlin, GermanyDepartment of Anesthesiology and Intensive Care, Klinik Hallerwiese-Cnopfsche Kinderklinik, 90419 Nurnberg, GermanyDepartment of Obstetrics, University Hospital Jena, 07747 Jena, GermanyDepartment of Obstetrics, Vivantes Klinikum Neukölln, 12351 Berlin, GermanyDepartment of Gynecology and Obstetrics, Hospital St. Hedweig of the Order of St. John, University Medical Center Regensburg, 93049 Regensburg, GermanyDepartment of Obstetrics and Gynaecology, Universitätsklinikum Erlangen, 91054 Erlangen, GermanyDepartment of Obstetrics and Gynecology, München Klinik Harlaching, 81545 Munich, GermanyDepartment of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, 97080 Wuerzburg, GermanyDepartment of Paediatrics, University Hospital Wuerzburg, 97080 Wuerzburg, GermanyDepartment of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, 97080 Wuerzburg, Germany(1) Background: Data on coronavirus 2 infection during pregnancy vary. We aimed to describe maternal characteristics and clinical presentation of SARS-CoV-2 positive women requiring intensive care treatment for COVID-19 during pregnancy and postpartum period based on data of a comprehensive German surveillance system in obstetric patients. (2) Methods: Data from COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS), a prospective multicenter registry for SARS-CoV-2 positive pregnant women, was analyzed with respect to ICU treatment. All women requiring intensive care treatment for COVID-19 were included and compared regarding maternal characteristics, course of disease, as well as maternal and neonatal outcomes. (3) Results: Of 2650 cases in CRONOS, 101 women (4%) had a documented ICU stay. Median maternal age was 33 (IQR, 30–36) years. COVID-19 was diagnosed at a median gestational age of 33 (IQR, 28–35) weeks. As the most invasive form of COVID-19 treatment interventions, patients received either continuous monitoring of vital signs without further treatment requirement (<i>n</i> = 6), insufflation of oxygen (<i>n</i> = 30), non-invasive ventilation (<i>n</i> = 22), invasive ventilation (<i>n</i> = 28), or escalation to extracorporeal membrane oxygenation (<i>n</i> = 15). No significant clinical differences were identified between patients receiving different forms of ventilatory support for COVID-19. Prevalence of preterm delivery was significantly higher in women receiving invasive respiratory treatments. Four women died of COVID-19 and six fetuses were stillborn. (4) Conclusions: Our cohort shows that progression of COVID-19 is rare in pregnant and postpartum women treated in the ICU. Preterm birth rate is high and COVID-19 requiring respiratory support increases the risk of poor maternal and neonatal outcome.https://www.mdpi.com/2077-0383/11/3/701maternal critical careCOVID-19ARDSSARS-CoV-2pregnancyobstetrics |
| spellingShingle | Magdalena Sitter Ulrich Pecks Mario Rüdiger Sabine Friedrich Sara Fill Malfertheiner Alexander Hein Josefine T. Königbauer Karin Becke-Jakob Janine Zöllkau Babett Ramsauer Katharina Rathberger Constanza A. Pontones Katrina Kraft Patrick Meybohm Christoph Härtel Peter Kranke CRONOS Network Pregnant and Postpartum Women Requiring Intensive Care Treatment for COVID-19—First Data from the CRONOS-Registry Journal of Clinical Medicine maternal critical care COVID-19 ARDS SARS-CoV-2 pregnancy obstetrics |
| title | Pregnant and Postpartum Women Requiring Intensive Care Treatment for COVID-19—First Data from the CRONOS-Registry |
| title_full | Pregnant and Postpartum Women Requiring Intensive Care Treatment for COVID-19—First Data from the CRONOS-Registry |
| title_fullStr | Pregnant and Postpartum Women Requiring Intensive Care Treatment for COVID-19—First Data from the CRONOS-Registry |
| title_full_unstemmed | Pregnant and Postpartum Women Requiring Intensive Care Treatment for COVID-19—First Data from the CRONOS-Registry |
| title_short | Pregnant and Postpartum Women Requiring Intensive Care Treatment for COVID-19—First Data from the CRONOS-Registry |
| title_sort | pregnant and postpartum women requiring intensive care treatment for covid 19 first data from the cronos registry |
| topic | maternal critical care COVID-19 ARDS SARS-CoV-2 pregnancy obstetrics |
| url | https://www.mdpi.com/2077-0383/11/3/701 |
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