Understanding the Representative Gut Microbiota Dysbiosis in Metformin-Treated Type 2 Diabetes Patients Using Genome-Scale Metabolic Modeling

Understanding the Representative Gut Microbiota Dysbiosis in Metformin-Treated Type 2 Diabetes Patients Using Genome-Scale Metabolic Modeling

Dysbiosis in the gut microbiome composition may be promoted by therapeutic drugs such as metformin, the world’s most prescribed antidiabetic drug. Under metformin treatment, disturbances of the intestinal microbes lead to increased abundance of Escherichia spp., Akkermansia muciniphila, Subdoligranu...

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Bibliographic Details
Main Authors: Dorines Rosario, Rui Benfeitas, Gholamreza Bidkhori, Cheng Zhang, Mathias Uhlen, Saeed Shoaie, Adil Mardinoglu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Physiology
Subjects:
gut microbiota
dysbiosis
host–microbiome interactions
genome-scale metabolic models
systems biology
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00775/full

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