Regulation of vesicular trafficking by Parkinson's disease-associated genes
The regulatory mechanisms that control intracellular vesicular trafficking play important roles in cellular function and viability. Neurons have specific vesicular trafficking systems for synaptic vesicle formation, release and recycling. Synaptic vesicular trafficking impairments induce neuronal dy...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2015-10-01
|
| Series: | AIMS Molecular Science |
| Subjects: | |
| Online Access: | http://www.aimspress.com/Molecular/article/489/fulltext.html |
| _version_ | 1818506454633545728 |
|---|---|
| author | Tsuyoshi Inoshita Yuzuru Imai |
| author_facet | Tsuyoshi Inoshita Yuzuru Imai |
| author_sort | Tsuyoshi Inoshita |
| collection | DOAJ |
| description | The regulatory mechanisms that control intracellular vesicular trafficking play important roles in cellular function and viability. Neurons have specific vesicular trafficking systems for synaptic vesicle formation, release and recycling. Synaptic vesicular trafficking impairments induce neuronal dysfunction and physiological and behavioral disorders. Parkinson's disease (PD) is an age-dependent neurodegenerative disorder characterized by dopamine depletion and loss of dopamine neurons in the midbrain. The molecular mechanism responsible for the neurodegeneration that occurs during PD is still not understood; however, recent functional analyses of familial PD causative genes suggest that a number of PD causative genes regulate intracellular vesicular trafficking, including synaptic vesicular dynamics. This review focuses on recent insights regarding the functions of PD causative genes, their relationship with vesicular trafficking and how mutations associated with PD affect vesicular dynamics and neuronal survival. |
| first_indexed | 2024-12-10T22:04:49Z |
| format | Article |
| id | doaj.art-3e451d9eee294e80aede579096bdf52a |
| institution | Directory Open Access Journal |
| issn | 2372-0301 |
| language | English |
| last_indexed | 2024-12-10T22:04:49Z |
| publishDate | 2015-10-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Molecular Science |
| spelling | doaj.art-3e451d9eee294e80aede579096bdf52a2022-12-22T01:31:47ZengAIMS PressAIMS Molecular Science2372-03012015-10-012446147510.3934/molsci.2015.4.461201504461Regulation of vesicular trafficking by Parkinson's disease-associated genesTsuyoshi Inoshita0Yuzuru Imai1Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, JapanThe regulatory mechanisms that control intracellular vesicular trafficking play important roles in cellular function and viability. Neurons have specific vesicular trafficking systems for synaptic vesicle formation, release and recycling. Synaptic vesicular trafficking impairments induce neuronal dysfunction and physiological and behavioral disorders. Parkinson's disease (PD) is an age-dependent neurodegenerative disorder characterized by dopamine depletion and loss of dopamine neurons in the midbrain. The molecular mechanism responsible for the neurodegeneration that occurs during PD is still not understood; however, recent functional analyses of familial PD causative genes suggest that a number of PD causative genes regulate intracellular vesicular trafficking, including synaptic vesicular dynamics. This review focuses on recent insights regarding the functions of PD causative genes, their relationship with vesicular trafficking and how mutations associated with PD affect vesicular dynamics and neuronal survival.http://www.aimspress.com/Molecular/article/489/fulltext.htmlParkinson's diseasevesicular traffickingsynaptic vesicle dynamicsendosomeexocytosisendocytosisretromerneurodegeneration |
| spellingShingle | Tsuyoshi Inoshita Yuzuru Imai Regulation of vesicular trafficking by Parkinson's disease-associated genes AIMS Molecular Science Parkinson's disease vesicular trafficking synaptic vesicle dynamics endosome exocytosis endocytosis retromer neurodegeneration |
| title | Regulation of vesicular trafficking by Parkinson's disease-associated genes |
| title_full | Regulation of vesicular trafficking by Parkinson's disease-associated genes |
| title_fullStr | Regulation of vesicular trafficking by Parkinson's disease-associated genes |
| title_full_unstemmed | Regulation of vesicular trafficking by Parkinson's disease-associated genes |
| title_short | Regulation of vesicular trafficking by Parkinson's disease-associated genes |
| title_sort | regulation of vesicular trafficking by parkinson s disease associated genes |
| topic | Parkinson's disease vesicular trafficking synaptic vesicle dynamics endosome exocytosis endocytosis retromer neurodegeneration |
| url | http://www.aimspress.com/Molecular/article/489/fulltext.html |
| work_keys_str_mv | AT tsuyoshiinoshita regulationofvesiculartraffickingbyparkinsonsdiseaseassociatedgenes AT yuzuruimai regulationofvesiculartraffickingbyparkinsonsdiseaseassociatedgenes |