Identification of the Optimal Cut-Off Value of PSA for Assessing Severity of Disease in [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT Study in Prostate Cancer Patients after Radical Prostatectomy
Objective: The objective of this study was to identify the optimal cut-off value of prostate specific antigen (PSA) to assess the extent of the disease in [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT study in patients after radical prostatectomy. Materials and Methods: Retrospective analysis was p...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-01-01
|
Series: | Diagnostics |
Subjects: | |
Online Access: | https://www.mdpi.com/2075-4418/12/2/349 |
_version_ | 1797481206163439616 |
---|---|
author | Paulina Cegla Marta Wojewódzka Izabela Gorczewska Wioletta Chalewska Grażyna Łapińska Paweł Ochman Agata Sackiewicz Marek Dedecjus |
author_facet | Paulina Cegla Marta Wojewódzka Izabela Gorczewska Wioletta Chalewska Grażyna Łapińska Paweł Ochman Agata Sackiewicz Marek Dedecjus |
author_sort | Paulina Cegla |
collection | DOAJ |
description | Objective: The objective of this study was to identify the optimal cut-off value of prostate specific antigen (PSA) to assess the extent of the disease in [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT study in patients after radical prostatectomy. Materials and Methods: Retrospective analysis was performed on a group of 215 patients who underwent a [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT examination because of suspected recurrence after radical prostatectomy. Patients were divided into four groups: 1, no active lesions suggesting recurrence (n = 92); 2, suspected isolated local recurrence (n = 19); 3, oligometastatic disease (n = 82); and 4, polymetastatic disease (n = 22). Results: In group 1, the mean PSA level was 0.962 ng/mL (median: 0.376; min: 0.004; max: 25 ng/mL); in group 2, it was 4.970 ng/mL (median 1.320; min: 0.003; max: 40.350 ng/mL); in group 3, it was 2.802 ng/mL (median: 1.270; min: 0.020; max: 59.670 ng/mL); and in group 4, it was 4.997 ng/mL (median: 3.795; min: 0.007; max 21.110 ng/mL). Statistically significant differences were shown in PSA levels when comparing groups 1 and 2 (<i>p</i> = 0.0025) and groups 3 and 4 (<i>p</i> = 0.0474). The PSA cut-off point for discriminating groups 1 and 2 was 0.831 (sensitivity: 0.684; specificity: 0.772; area under the curve (AUC): 0.775), and for groups 3 and 4, it was 2.51 (sensitivity: 0.682; specificity: 0.780; AUC: 0.720). Conclusions: Our preliminary data suggested that the PSA level has an essential influence on determining the extent of disease in a [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT study in patients after radical prostatectomy. Identification of the optimal cut-off values for the oligo- and polymetastatic diseases might be helpful in stratifying these patients. |
first_indexed | 2024-03-09T22:11:11Z |
format | Article |
id | doaj.art-3e469f50c7454ba3817664e0c27c0f74 |
institution | Directory Open Access Journal |
issn | 2075-4418 |
language | English |
last_indexed | 2024-03-09T22:11:11Z |
publishDate | 2022-01-01 |
publisher | MDPI AG |
record_format | Article |
series | Diagnostics |
spelling | doaj.art-3e469f50c7454ba3817664e0c27c0f742023-11-23T19:30:34ZengMDPI AGDiagnostics2075-44182022-01-0112234910.3390/diagnostics12020349Identification of the Optimal Cut-Off Value of PSA for Assessing Severity of Disease in [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT Study in Prostate Cancer Patients after Radical ProstatectomyPaulina Cegla0Marta Wojewódzka1Izabela Gorczewska2Wioletta Chalewska3Grażyna Łapińska4Paweł Ochman5Agata Sackiewicz6Marek Dedecjus7Department of Endocrine Oncology and Nuclear Medicine, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, PolandDepartment of Endocrine Oncology and Nuclear Medicine, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, PolandDepartment of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 44-102 Gliwice, PolandDepartment of Endocrine Oncology and Nuclear Medicine, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, PolandDepartment of Endocrine Oncology and Nuclear Medicine, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, PolandDepartment of Endocrine Oncology and Nuclear Medicine, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, PolandDepartment of Endocrine Oncology and Nuclear Medicine, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, PolandDepartment of Endocrine Oncology and Nuclear Medicine, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, PolandObjective: The objective of this study was to identify the optimal cut-off value of prostate specific antigen (PSA) to assess the extent of the disease in [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT study in patients after radical prostatectomy. Materials and Methods: Retrospective analysis was performed on a group of 215 patients who underwent a [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT examination because of suspected recurrence after radical prostatectomy. Patients were divided into four groups: 1, no active lesions suggesting recurrence (n = 92); 2, suspected isolated local recurrence (n = 19); 3, oligometastatic disease (n = 82); and 4, polymetastatic disease (n = 22). Results: In group 1, the mean PSA level was 0.962 ng/mL (median: 0.376; min: 0.004; max: 25 ng/mL); in group 2, it was 4.970 ng/mL (median 1.320; min: 0.003; max: 40.350 ng/mL); in group 3, it was 2.802 ng/mL (median: 1.270; min: 0.020; max: 59.670 ng/mL); and in group 4, it was 4.997 ng/mL (median: 3.795; min: 0.007; max 21.110 ng/mL). Statistically significant differences were shown in PSA levels when comparing groups 1 and 2 (<i>p</i> = 0.0025) and groups 3 and 4 (<i>p</i> = 0.0474). The PSA cut-off point for discriminating groups 1 and 2 was 0.831 (sensitivity: 0.684; specificity: 0.772; area under the curve (AUC): 0.775), and for groups 3 and 4, it was 2.51 (sensitivity: 0.682; specificity: 0.780; AUC: 0.720). Conclusions: Our preliminary data suggested that the PSA level has an essential influence on determining the extent of disease in a [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT study in patients after radical prostatectomy. Identification of the optimal cut-off values for the oligo- and polymetastatic diseases might be helpful in stratifying these patients.https://www.mdpi.com/2075-4418/12/2/349positron emission tomography/computed tomographyprostate-specific membrane antigenprostate cancer |
spellingShingle | Paulina Cegla Marta Wojewódzka Izabela Gorczewska Wioletta Chalewska Grażyna Łapińska Paweł Ochman Agata Sackiewicz Marek Dedecjus Identification of the Optimal Cut-Off Value of PSA for Assessing Severity of Disease in [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT Study in Prostate Cancer Patients after Radical Prostatectomy Diagnostics positron emission tomography/computed tomography prostate-specific membrane antigen prostate cancer |
title | Identification of the Optimal Cut-Off Value of PSA for Assessing Severity of Disease in [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT Study in Prostate Cancer Patients after Radical Prostatectomy |
title_full | Identification of the Optimal Cut-Off Value of PSA for Assessing Severity of Disease in [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT Study in Prostate Cancer Patients after Radical Prostatectomy |
title_fullStr | Identification of the Optimal Cut-Off Value of PSA for Assessing Severity of Disease in [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT Study in Prostate Cancer Patients after Radical Prostatectomy |
title_full_unstemmed | Identification of the Optimal Cut-Off Value of PSA for Assessing Severity of Disease in [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT Study in Prostate Cancer Patients after Radical Prostatectomy |
title_short | Identification of the Optimal Cut-Off Value of PSA for Assessing Severity of Disease in [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT Study in Prostate Cancer Patients after Radical Prostatectomy |
title_sort | identification of the optimal cut off value of psa for assessing severity of disease in sup 68 sup ga ga psma 11 pet ct study in prostate cancer patients after radical prostatectomy |
topic | positron emission tomography/computed tomography prostate-specific membrane antigen prostate cancer |
url | https://www.mdpi.com/2075-4418/12/2/349 |
work_keys_str_mv | AT paulinacegla identificationoftheoptimalcutoffvalueofpsaforassessingseverityofdiseaseinsup68supgagapsma11petctstudyinprostatecancerpatientsafterradicalprostatectomy AT martawojewodzka identificationoftheoptimalcutoffvalueofpsaforassessingseverityofdiseaseinsup68supgagapsma11petctstudyinprostatecancerpatientsafterradicalprostatectomy AT izabelagorczewska identificationoftheoptimalcutoffvalueofpsaforassessingseverityofdiseaseinsup68supgagapsma11petctstudyinprostatecancerpatientsafterradicalprostatectomy AT wiolettachalewska identificationoftheoptimalcutoffvalueofpsaforassessingseverityofdiseaseinsup68supgagapsma11petctstudyinprostatecancerpatientsafterradicalprostatectomy AT grazynałapinska identificationoftheoptimalcutoffvalueofpsaforassessingseverityofdiseaseinsup68supgagapsma11petctstudyinprostatecancerpatientsafterradicalprostatectomy AT pawełochman identificationoftheoptimalcutoffvalueofpsaforassessingseverityofdiseaseinsup68supgagapsma11petctstudyinprostatecancerpatientsafterradicalprostatectomy AT agatasackiewicz identificationoftheoptimalcutoffvalueofpsaforassessingseverityofdiseaseinsup68supgagapsma11petctstudyinprostatecancerpatientsafterradicalprostatectomy AT marekdedecjus identificationoftheoptimalcutoffvalueofpsaforassessingseverityofdiseaseinsup68supgagapsma11petctstudyinprostatecancerpatientsafterradicalprostatectomy |