Effects of Oral 5-Aminolevulinic Acid on Lipopolysaccharide-Induced Ocular Inflammation in Rats

Effects of Oral 5-Aminolevulinic Acid on Lipopolysaccharide-Induced Ocular Inflammation in Rats

This study aimed to investigate the anti-inflammatory effect of 5-aminolevulinic acid (5-ALA) on endotoxin-induced uveitis (EIU) in rats. EIU was induced in male Sprague Dawley rats by the subcutaneous injection of lipopolysaccharide (LPS). During LPS injection, 5-ALA diluted with saline was adminis...

Full description

Bibliographic Details
Main Authors:	Yuya Otaka, Kazutaka Kanai, Daiki Okada, Noriaki Nagai, Yohei Yamashita, Yoichiro Ichikawa, Kazuki Tajima
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Series:	Veterinary Sciences
Subjects:	anti-inflammatory effect endotoxin-induced uveitis 5-aminolevulinic acid
Online Access:	https://www.mdpi.com/2306-7381/10/3/207

Similar Items

Sodium Ferrous Citrate and 5-Aminolevulinic Acid Exert a Therapeutic Effect on Endotoxin-Induced Uveitis in Rats
by: Yuya Otaka, et al.
Published: (2023-08-01)

5-ALA/SFC Ameliorates Endotoxin-Induced Ocular Inflammation in Rats by Inhibiting the NF-κB Signaling Pathway and Activating the HO-1/Nrf2 Signaling Pathway
by: Yuya Otaka, et al.
Published: (2023-05-01)

Lipocalin 2 Suppresses Ocular Inflammation by Inhibiting the Activation of NF-κβ Pathway in Endotoxin-Induced Uveitis
by: Wenyi Tang, et al.
Published: (2018-03-01)

Reason for the particular sensitivity of rats' ocular tissues to endotoxin
by: Wei-Ming Yan, et al.
Published: (2020-01-01)

Systemic and Ocular Anti-Inflammatory Mechanisms of Green Tea Extract on Endotoxin-Induced Ocular Inflammation
by: Kai On Chu, et al.
Published: (2022-07-01)

Theissenolactone C Exhibited Ocular Protection of Endotoxin-Induced Uveitis by Attenuating Ocular Inflammatory Responses and Glial Activation
by: Fan-Li Lin, et al.
Published: (2018-04-01)

5-Aminolevulinic acid improves chicken sperm motility
by: Shin Taniguchi, et al.
Published: (2021-12-01)

Bacterial lipopolysaccharides : structure, synthesis and biological activities/
by: Anderson, Laurens, et al.
Published: (1983)

Bevacizumab Diminishes Inflammation in an Acute Endotoxin-Induced Uveitis Model
by: Salvador Mérida, et al.
Published: (2018-06-01)

The use of 5-aminolevulinic acid and its derivatives in photodynamic therapy and diagnosis
by: Anna Romiszewska, et al.
Published: (2018-12-01)

Magnesium Hydroxide Nanoparticles Improve the Ocular Hypotensive Effect of Twice Daily Topical Timolol Maleate in Healthy Dogs
by: Mizuki Kita, et al.
Published: (2021-08-01)

Synergistic Cytotoxic Effect of Gold Nanoparticles and 5-Aminolevulinic Acid-Mediated Photodynamic Therapy against Skin Cancer Cells
by: Mahnaz Hadizadeh, et al.
Published: (2014-09-01)

Efficacy of 5-Aminolevulinic Acid in Photodynamic Detection and Photodynamic Therapy in Veterinary Medicine
by: Tomohiro Osaki, et al.
Published: (2019-04-01)

5-Aminolevulinic acid photodynamic diagnosis of laryngeal papillomatosis
by: I. G. Guseinov, et al.
Published: (2019-07-01)

Reappraisal of Blood Lead Levels and Relation to Delta-Aminolevulinic Acid Dehydratase, Zinc Protoporphyrin and Urinary ALA Level in Thai Normal Adults and Lead Exposed Workers
by: Watcharachai Rujirojkul
Published: (2008-01-01)

Effects of 5-aminolevulinic acid on the inflammatory responses and antioxidative capacity in broiler chickens challenged with lipopolysaccharide
by: Jiang Chen, et al.
Published: (2022-07-01)

Effectiveness of 5-aminolevulinic Acid-mediated Photodynamic Therapy Combined With Curcumin
by: Siu Kan Law
Published: (2023-07-01)

Genetic factors affecting intraoperative 5-aminolevulinic acid-induced fluorescence of diffuse gliomas
by: Saito Kiyotaka, et al.
Published: (2017-05-01)

Effect of 5-aminolevulinic Acid on Mitochondrial Activity
by: Yuliya V. Markina, et al.
Published: (2023-12-01)

Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke
by: Masanori Hijioka, et al.
Published: (2020-11-01)

Identification of risk factors for post-induction hypotension in patients receiving 5-aminolevulinic acid: a single-center retrospective study
by: Tomoaki Yatabe, et al.
Published: (2020-05-01)

Peculiarities of epicutaneous action of hexyl ether of 5-aminolevulinic acid
by: Е.K. Vlasenko, et al.
Published: (2015-03-01)

Detection of Canine Urothelial Carcinoma Cells in Urine Using 5-Aminolevulinic Acid
by: Kenjiro Kaji, et al.
Published: (2022-02-01)

Enhancement of 5-aminolevulinic acid-induced photodynamic therapy by a bioadhesive polymer
by: Shu-Fang Chang, et al.
Published: (2010-03-01)

Photodynamic therapy with methyl aminolevulinate in the treatment of basal cell carcinoma
by: A. A. Kubanov, et al.
Published: (2017-08-01)

Efficacy and Safety of 5-Aminolevulinic Acid for Patients with Symptoms of Late-Onset Hypogonadism: A Preliminary Study
by: Hiroki Koyasu, et al.
Published: (2022-07-01)

The effects of the heme precursor 5-aminolevulinic acid (ALA) on REV-ERBα activation
by: Kohei Yamashita, et al.
Published: (2014-01-01)

5-Aminolevulinic acid: A matter of life and caveats
by: Etelvino J.H. Bechara, et al.
Published: (2021-09-01)

5-Aminolevulinic acid photoactivated over planktonic and biofilm forms of Enterococcus faecalis as a pharmacological therapy alternative
by: Adriana Beltran-Leal, et al.
Published: (2020-09-01)

5-Aminolevulinic acid-induced severe hypotension during transurethral resection of a bladder tumor: a case report
by: Tomoaki Yatabe, et al.
Published: (2019-09-01)

Effects of aluminum sulfate on delta-aminolevulinate dehydratase from kidney, brain, and liver of adult mice
by: M.R.C. Schetinger, et al.
Published: (1999-06-01)

Hexyl-Aminolevulinate Ethosomes: a Novel Antibiofilm Agent Targeting Zinc Homeostasis in Candida albicans
by: Yingzhe Wang, et al.
Published: (2022-12-01)

Inhibition of Notch1 Signaling Alleviates Endotoxin-Induced Inflammation Through Modulating Retinal Microglia Polarization
by: Zhixing Cheng, et al.
Published: (2019-03-01)

Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer
by: Jakub Golab, et al.
Published: (2011-05-01)

Seven steps to diagnose delta-aminolevulinic acid deficiency porphyria
by: Adriana Grigore, et al.
Published: (2017-12-01)

5-Aminolevulinic Acid Pretreatment Mitigates Drought and Salt Stresses in Poplar Plants
by: Zhiyin Jiao, et al.
Published: (2021-08-01)

5-Aminolevulinic Acid-Squalene Nanoassemblies for Tumor Photodetection and Therapy: In Vitro Studies
by: Andrej Babič, et al.
Published: (2018-01-01)

Antifungal Photodynamic Activity of Hexyl-Aminolevulinate Ethosomes Against Candida albicans Biofilm
by: Yingzhe Wang, et al.
Published: (2020-09-01)

Fluorescence Guided Surgery with 5-Aminolevulinic Acid for Resection of Spinal Cord Ependymomas
by: Rafael García Moreno, et al.
Published: (2019-02-01)

The efficacy of intravitreal interferon alpha-2b for the treatment of experimental endotoxin-induced uveitis
by: Mehrdad Afarid, et al.
Published: (2016-01-01)