Renoprotective effect of febuxostat on contrast-induced acute kidney injury in chronic kidney disease patients stage 3: randomized controlled trial
Abstract Introduction Contrast-induced acute kidney injury (CI-AKI) is known to be a complication of using intravascular contrast injection. Unfortunately, it is associated with adverse outcomes such as prolonged length of hospitalization and increased burden of health care costs. So, we aimed to de...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-023-03114-4 |
| _version_ | 1797860011352784896 |
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| author | Iman Ibrahim Sarhan Yasser A. Abdellatif Rania Elsayed Saad Nahla Mohamed Teama |
| author_facet | Iman Ibrahim Sarhan Yasser A. Abdellatif Rania Elsayed Saad Nahla Mohamed Teama |
| author_sort | Iman Ibrahim Sarhan |
| collection | DOAJ |
| description | Abstract Introduction Contrast-induced acute kidney injury (CI-AKI) is known to be a complication of using intravascular contrast injection. Unfortunately, it is associated with adverse outcomes such as prolonged length of hospitalization and increased burden of health care costs. So, we aimed to determine the efficacy of febuxostat in the prevention of contrast-induced acute kidney injury among patients with chronic kidney disease Stage 3 performing percutaneous coronary intervention (PCI). Methods In a randomized controlled trial we enrolled 120 CKD stage 3 Patients with acute coronary syndrome referred to the cardiology department Ain-Shams University hospital for performing PCI and stenting. Patients were randomly assigned to two arms: Group I (study group): Included 60 patients who received Febuxostat added to the traditional treatment (IV hydration and N-acetylcysteine). The patients received Feburic 80 mg within 6–18 h before and within 6–18 h after the coronary intervention (a time gap of 24 h between two doses). Group II (control group): included 60 patients who received only traditional treatment. Results The incidence of AKI was higher in the control group with a statistically significant difference. We found that Independent Significant risk factors that led to AKI were febuxostate avoidance, DM, high urea level, high creatinine level, CKD stage 3B, high Mehran score and high AKI risk. Conclusion We demonstrated that febuxostat has a Reno protective effect and it can help to reduce the incidence CI-AKI in CKD patients stage 3 performing PCI. |
| first_indexed | 2024-04-09T21:38:49Z |
| format | Article |
| id | doaj.art-3e474cc33b424fc48fb0083d7e7f99c2 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-04-09T21:38:49Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-3e474cc33b424fc48fb0083d7e7f99c22023-03-26T11:07:48ZengBMCBMC Nephrology1471-23692023-03-0124111110.1186/s12882-023-03114-4Renoprotective effect of febuxostat on contrast-induced acute kidney injury in chronic kidney disease patients stage 3: randomized controlled trialIman Ibrahim Sarhan0Yasser A. Abdellatif1Rania Elsayed Saad2Nahla Mohamed Teama3Department of Internal Medicine and Nephrology, Faculty of Medicine, Ain Shams UniversityDepartment of Cardiology, Faculty of Medicine, Ain Shams UniversityDepartment of Nephrology, Elsahel teaching hospitalDepartment of Internal Medicine and Nephrology, Faculty of Medicine, Ain Shams UniversityAbstract Introduction Contrast-induced acute kidney injury (CI-AKI) is known to be a complication of using intravascular contrast injection. Unfortunately, it is associated with adverse outcomes such as prolonged length of hospitalization and increased burden of health care costs. So, we aimed to determine the efficacy of febuxostat in the prevention of contrast-induced acute kidney injury among patients with chronic kidney disease Stage 3 performing percutaneous coronary intervention (PCI). Methods In a randomized controlled trial we enrolled 120 CKD stage 3 Patients with acute coronary syndrome referred to the cardiology department Ain-Shams University hospital for performing PCI and stenting. Patients were randomly assigned to two arms: Group I (study group): Included 60 patients who received Febuxostat added to the traditional treatment (IV hydration and N-acetylcysteine). The patients received Feburic 80 mg within 6–18 h before and within 6–18 h after the coronary intervention (a time gap of 24 h between two doses). Group II (control group): included 60 patients who received only traditional treatment. Results The incidence of AKI was higher in the control group with a statistically significant difference. We found that Independent Significant risk factors that led to AKI were febuxostate avoidance, DM, high urea level, high creatinine level, CKD stage 3B, high Mehran score and high AKI risk. Conclusion We demonstrated that febuxostat has a Reno protective effect and it can help to reduce the incidence CI-AKI in CKD patients stage 3 performing PCI.https://doi.org/10.1186/s12882-023-03114-4Contrast induced acute kidney injuryFebuxostatPercutaneous coronary interventionContrast |
| spellingShingle | Iman Ibrahim Sarhan Yasser A. Abdellatif Rania Elsayed Saad Nahla Mohamed Teama Renoprotective effect of febuxostat on contrast-induced acute kidney injury in chronic kidney disease patients stage 3: randomized controlled trial BMC Nephrology Contrast induced acute kidney injury Febuxostat Percutaneous coronary intervention Contrast |
| title | Renoprotective effect of febuxostat on contrast-induced acute kidney injury in chronic kidney disease patients stage 3: randomized controlled trial |
| title_full | Renoprotective effect of febuxostat on contrast-induced acute kidney injury in chronic kidney disease patients stage 3: randomized controlled trial |
| title_fullStr | Renoprotective effect of febuxostat on contrast-induced acute kidney injury in chronic kidney disease patients stage 3: randomized controlled trial |
| title_full_unstemmed | Renoprotective effect of febuxostat on contrast-induced acute kidney injury in chronic kidney disease patients stage 3: randomized controlled trial |
| title_short | Renoprotective effect of febuxostat on contrast-induced acute kidney injury in chronic kidney disease patients stage 3: randomized controlled trial |
| title_sort | renoprotective effect of febuxostat on contrast induced acute kidney injury in chronic kidney disease patients stage 3 randomized controlled trial |
| topic | Contrast induced acute kidney injury Febuxostat Percutaneous coronary intervention Contrast |
| url | https://doi.org/10.1186/s12882-023-03114-4 |
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