Use of Circular RNAs in Diagnosis, Prognosis and Therapeutics of Renal Cell Carcinoma
Renal cell carcinoma is the most common type of kidney cancer, representing 90% of kidney cancer diagnoses, and the deadliest urological cancer. While the incidence and mortality rates by renal cell carcinoma are higher in men compared to women, in both sexes the clinical characteristics are the sam...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.879814/full |
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| author | Rebeca Osca-Verdegal Rebeca Osca-Verdegal Jesús Beltrán-García Jesús Beltrán-García Jesús Beltrán-García José Luis Górriz José María Martínez Jabaloyas Federico V. Pallardó Federico V. Pallardó Federico V. Pallardó José Luis García-Giménez José Luis García-Giménez José Luis García-Giménez José Luis García-Giménez |
| author_facet | Rebeca Osca-Verdegal Rebeca Osca-Verdegal Jesús Beltrán-García Jesús Beltrán-García Jesús Beltrán-García José Luis Górriz José María Martínez Jabaloyas Federico V. Pallardó Federico V. Pallardó Federico V. Pallardó José Luis García-Giménez José Luis García-Giménez José Luis García-Giménez José Luis García-Giménez |
| author_sort | Rebeca Osca-Verdegal |
| collection | DOAJ |
| description | Renal cell carcinoma is the most common type of kidney cancer, representing 90% of kidney cancer diagnoses, and the deadliest urological cancer. While the incidence and mortality rates by renal cell carcinoma are higher in men compared to women, in both sexes the clinical characteristics are the same, and usually unspecific, thereby hindering and delaying the diagnostic process and increasing the metastatic potential. Regarding treatment, surgical resection remains the main therapeutic strategy. However, even after radical nephrectomy, metastasis may still occur in some patients, with most metastatic renal cell carcinomas being resistant to chemotherapy and radiotherapy. Therefore, the identification of new biomarkers to help clinicians in the early detection, and treatment of renal cell carcinoma is essential. In this review, we describe circRNAs related to renal cell carcinoma processes reported to date and propose the use of some in therapeutic strategies for renal cell carcinoma treatment. |
| first_indexed | 2024-04-13T16:52:46Z |
| format | Article |
| id | doaj.art-3e47ba969e7e4a3abfa54a0ed6067c2a |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-13T16:52:46Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-3e47ba969e7e4a3abfa54a0ed6067c2a2022-12-22T02:38:53ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-06-011010.3389/fcell.2022.879814879814Use of Circular RNAs in Diagnosis, Prognosis and Therapeutics of Renal Cell CarcinomaRebeca Osca-Verdegal0Rebeca Osca-Verdegal1Jesús Beltrán-García2Jesús Beltrán-García3Jesús Beltrán-García4José Luis Górriz5José María Martínez Jabaloyas6Federico V. Pallardó7Federico V. Pallardó8Federico V. Pallardó9José Luis García-Giménez10José Luis García-Giménez11José Luis García-Giménez12José Luis García-Giménez13Center for Biomedical Network Research on Rare Diseases (CIBERER), Institute of Health Carlos III, Valencia, SpainDepartment of Physiology, Faculty of Medicine and Dentistry, University of Valencia, Valencia, SpainCenter for Biomedical Network Research on Rare Diseases (CIBERER), Institute of Health Carlos III, Valencia, SpainDepartment of Physiology, Faculty of Medicine and Dentistry, University of Valencia, Valencia, SpainINCLIVA Biomedical Research Institute, Valencia, SpainDepartment of Nephrology, University Clinic Hospital, INCLIVA, University of Valencia, Valencia, SpainDepartment of Urology, University Clinic Hospital, INCLIVA, University of Valencia, Valencia, SpainCenter for Biomedical Network Research on Rare Diseases (CIBERER), Institute of Health Carlos III, Valencia, SpainDepartment of Physiology, Faculty of Medicine and Dentistry, University of Valencia, Valencia, SpainINCLIVA Biomedical Research Institute, Valencia, SpainCenter for Biomedical Network Research on Rare Diseases (CIBERER), Institute of Health Carlos III, Valencia, SpainDepartment of Physiology, Faculty of Medicine and Dentistry, University of Valencia, Valencia, SpainINCLIVA Biomedical Research Institute, Valencia, SpainEpiDisease S.L. (Spin-Off CIBER-ISCIII), Parc Científic de la Universitat de València, Valencia, SpainRenal cell carcinoma is the most common type of kidney cancer, representing 90% of kidney cancer diagnoses, and the deadliest urological cancer. While the incidence and mortality rates by renal cell carcinoma are higher in men compared to women, in both sexes the clinical characteristics are the same, and usually unspecific, thereby hindering and delaying the diagnostic process and increasing the metastatic potential. Regarding treatment, surgical resection remains the main therapeutic strategy. However, even after radical nephrectomy, metastasis may still occur in some patients, with most metastatic renal cell carcinomas being resistant to chemotherapy and radiotherapy. Therefore, the identification of new biomarkers to help clinicians in the early detection, and treatment of renal cell carcinoma is essential. In this review, we describe circRNAs related to renal cell carcinoma processes reported to date and propose the use of some in therapeutic strategies for renal cell carcinoma treatment.https://www.frontiersin.org/articles/10.3389/fcell.2022.879814/fullRCC (Renal Cell Carcinoma)circRNAsbiomarkerdiagnosistherapycancer |
| spellingShingle | Rebeca Osca-Verdegal Rebeca Osca-Verdegal Jesús Beltrán-García Jesús Beltrán-García Jesús Beltrán-García José Luis Górriz José María Martínez Jabaloyas Federico V. Pallardó Federico V. Pallardó Federico V. Pallardó José Luis García-Giménez José Luis García-Giménez José Luis García-Giménez José Luis García-Giménez Use of Circular RNAs in Diagnosis, Prognosis and Therapeutics of Renal Cell Carcinoma Frontiers in Cell and Developmental Biology RCC (Renal Cell Carcinoma) circRNAs biomarker diagnosis therapy cancer |
| title | Use of Circular RNAs in Diagnosis, Prognosis and Therapeutics of Renal Cell Carcinoma |
| title_full | Use of Circular RNAs in Diagnosis, Prognosis and Therapeutics of Renal Cell Carcinoma |
| title_fullStr | Use of Circular RNAs in Diagnosis, Prognosis and Therapeutics of Renal Cell Carcinoma |
| title_full_unstemmed | Use of Circular RNAs in Diagnosis, Prognosis and Therapeutics of Renal Cell Carcinoma |
| title_short | Use of Circular RNAs in Diagnosis, Prognosis and Therapeutics of Renal Cell Carcinoma |
| title_sort | use of circular rnas in diagnosis prognosis and therapeutics of renal cell carcinoma |
| topic | RCC (Renal Cell Carcinoma) circRNAs biomarker diagnosis therapy cancer |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.879814/full |
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