Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents
Esophageal stricture (ES) results from benign and malignant conditions, such as uncontrolled gastroesophageal reflux disease (GERD) and esophageal neoplasms. Upper gastrointestinal endoscopy is the preferred diagnostic approach for ES and its underlying causes. Stent insertion using an endoscope is...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1327517/full |
| _version_ | 1797403211029544960 |
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| author | Yaochen Yang Yaochen Yang Yuanyuan Yang Zhipeng Hou Tingting Wang Peng Wu Lufan Shen Peng Li Kai Zhang Liqun Yang Liqun Yang Siyu Sun |
| author_facet | Yaochen Yang Yaochen Yang Yuanyuan Yang Zhipeng Hou Tingting Wang Peng Wu Lufan Shen Peng Li Kai Zhang Liqun Yang Liqun Yang Siyu Sun |
| author_sort | Yaochen Yang |
| collection | DOAJ |
| description | Esophageal stricture (ES) results from benign and malignant conditions, such as uncontrolled gastroesophageal reflux disease (GERD) and esophageal neoplasms. Upper gastrointestinal endoscopy is the preferred diagnostic approach for ES and its underlying causes. Stent insertion using an endoscope is a prevalent method for alleviating or treating ES. Nevertheless, the widely used self-expandable metal stents (SEMS) and self-expandable plastic stents (SEPS) can result in complications such as migration and restenosis. Furthermore, they necessitate secondary extraction in cases of benign esophageal stricture (BES), rendering them unsatisfactory for clinical requirements. Over the past 3 decades, significant attention has been devoted to biodegradable materials, including synthetic polyester polymers and magnesium-based alloys, owing to their exceptional biocompatibility and biodegradability while addressing the challenges associated with recurring procedures after BES resolves. Novel esophageal stents have been developed and are undergoing experimental and clinical trials. Drug-eluting stents (DES) with drug-loading and drug-releasing capabilities are currently a research focal point, offering more efficient and precise ES treatments. Functional innovations have been investigated to optimize stent performance, including unidirectional drug-release and anti-migration features. Emerging manufacturing technologies such as three-dimensional (3D) printing and new biodegradable materials such as hydrogels have also contributed to the innovation of esophageal stents. The ultimate objective of the research and development of these materials is their clinical application in the treatment of ES and other benign conditions and the palliative treatment of malignant esophageal stricture (MES). This review aimed to offer a comprehensive overview of current biodegradable esophageal stent materials and their applications, highlight current research limitations and innovations, and offer insights into future development priorities and directions. |
| first_indexed | 2024-03-09T02:36:13Z |
| format | Article |
| id | doaj.art-3e47e7be75fb4c4495d4921e3642a6e8 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-09T02:36:13Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-3e47e7be75fb4c4495d4921e3642a6e82023-12-06T08:28:22ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-12-011110.3389/fbioe.2023.13275171327517Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stentsYaochen Yang0Yaochen Yang1Yuanyuan Yang2Zhipeng Hou3Tingting Wang4Peng Wu5Lufan Shen6Peng Li7Kai Zhang8Liqun Yang9Liqun Yang10Siyu Sun11Department of Gastroenterology, Endoscopic Center, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang, ChinaResearch Center for Biomedical Materials, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Gastroenterology, Endoscopic Center, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang, ChinaResearch Center for Biomedical Materials, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Gastroenterology, Endoscopic Center, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Gastroenterology, Endoscopic Center, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Gastroenterology, Endoscopic Center, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang, ChinaLiaoning Research Institute for Eugenic Birth and Fertility, China Medical University, Shenyang, ChinaDepartment of Gastroenterology, Endoscopic Center, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang, ChinaResearch Center for Biomedical Materials, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang, ChinaLiaoning Research Institute for Eugenic Birth and Fertility, China Medical University, Shenyang, ChinaDepartment of Gastroenterology, Endoscopic Center, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang, ChinaEsophageal stricture (ES) results from benign and malignant conditions, such as uncontrolled gastroesophageal reflux disease (GERD) and esophageal neoplasms. Upper gastrointestinal endoscopy is the preferred diagnostic approach for ES and its underlying causes. Stent insertion using an endoscope is a prevalent method for alleviating or treating ES. Nevertheless, the widely used self-expandable metal stents (SEMS) and self-expandable plastic stents (SEPS) can result in complications such as migration and restenosis. Furthermore, they necessitate secondary extraction in cases of benign esophageal stricture (BES), rendering them unsatisfactory for clinical requirements. Over the past 3 decades, significant attention has been devoted to biodegradable materials, including synthetic polyester polymers and magnesium-based alloys, owing to their exceptional biocompatibility and biodegradability while addressing the challenges associated with recurring procedures after BES resolves. Novel esophageal stents have been developed and are undergoing experimental and clinical trials. Drug-eluting stents (DES) with drug-loading and drug-releasing capabilities are currently a research focal point, offering more efficient and precise ES treatments. Functional innovations have been investigated to optimize stent performance, including unidirectional drug-release and anti-migration features. Emerging manufacturing technologies such as three-dimensional (3D) printing and new biodegradable materials such as hydrogels have also contributed to the innovation of esophageal stents. The ultimate objective of the research and development of these materials is their clinical application in the treatment of ES and other benign conditions and the palliative treatment of malignant esophageal stricture (MES). This review aimed to offer a comprehensive overview of current biodegradable esophageal stent materials and their applications, highlight current research limitations and innovations, and offer insights into future development priorities and directions.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1327517/fullbiodegradable esophageal stentsesophageal strictureesophageal cancerpolydioxanonepoly (L-lactic-acid)magnesium alloy |
| spellingShingle | Yaochen Yang Yaochen Yang Yuanyuan Yang Zhipeng Hou Tingting Wang Peng Wu Lufan Shen Peng Li Kai Zhang Liqun Yang Liqun Yang Siyu Sun Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents Frontiers in Bioengineering and Biotechnology biodegradable esophageal stents esophageal stricture esophageal cancer polydioxanone poly (L-lactic-acid) magnesium alloy |
| title | Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents |
| title_full | Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents |
| title_fullStr | Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents |
| title_full_unstemmed | Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents |
| title_short | Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents |
| title_sort | comprehensive review of materials applications and future innovations in biodegradable esophageal stents |
| topic | biodegradable esophageal stents esophageal stricture esophageal cancer polydioxanone poly (L-lactic-acid) magnesium alloy |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1327517/full |
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