Prone position in the mechanical ventilation of acute respiratory distress syndrome children: a systematic review and meta-analysis
BackgroundProne position has been well recognized for the treatment of adult acute respiratory distress syndrome (ARDS). We aimed to evaluate the role of prone position in the mechanical ventilation in children with ARDS, to provide evidence to the treatment and care of children with ARDS.MethodsWe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1293453/full |
| _version_ | 1797271381481619456 |
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| author | Wen Qin Lei Mao Yue Shen Li Zhao |
| author_facet | Wen Qin Lei Mao Yue Shen Li Zhao |
| author_sort | Wen Qin |
| collection | DOAJ |
| description | BackgroundProne position has been well recognized for the treatment of adult acute respiratory distress syndrome (ARDS). We aimed to evaluate the role of prone position in the mechanical ventilation in children with ARDS, to provide evidence to the treatment and care of children with ARDS.MethodsWe searched the Pubmed et al. databases by computer until January 23, 2024 for randomized controlled trials (RCTs) on the role of prone position in the mechanical ventilation in children with ARDS. We evaluated the quality of included studies according to the quality evaluation criteria recommended by the Cochrane library. RevMan 5.3 software was used for meta-analysis.Results7 RCTs involving 433 children with ARDS were included. Meta-analysis indicated that prone position is beneficial to improve the arterial oxygenation pressure [MD = 4.27 mmHg, 95% CI (3.49, 5.06)], PaO2/FiO2 [MD = 26.97, 95% CI (19.17, 34.77)], reduced the oxygenation index [MD = −3.52, 95% CI (−5.41, −1.64)], mean airway pressure [MD = −1.91 cmH2O, 95% CI (−2.27, −1.55)] and mortality [OR = 0.33, 95% CI (0.15, 0.73), all P < 0.05]. There were no statistical differences in the duration of mechanical ventilation between the prone position group and control group [MD = −17.01, 97.27, 95% CI (−38.28, 4.26), P = 0.12]. Egger test results showed that no significant publication bias was found (all P > 0.05).ConclusionsProne position ventilation has obvious advantages in improving oxygenation, but there is no significant improvement in the time of mechanical ventilation in the treatment of children with ARDS. In the future, more large-sample, high-quality RCTs are still needed to further analyze the role of prone position in the mechanical ventilation in children with ARDS. |
| first_indexed | 2024-03-07T14:01:55Z |
| format | Article |
| id | doaj.art-3e4d31dd7e7e47c9be1fc7256c62150e |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-07T14:01:55Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-3e4d31dd7e7e47c9be1fc7256c62150e2024-03-07T05:03:55ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-03-011210.3389/fped.2024.12934531293453Prone position in the mechanical ventilation of acute respiratory distress syndrome children: a systematic review and meta-analysisWen Qin0Lei Mao1Yue Shen2Li Zhao3Department of Emergency, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Emergency, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaPICU, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Emergency, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaBackgroundProne position has been well recognized for the treatment of adult acute respiratory distress syndrome (ARDS). We aimed to evaluate the role of prone position in the mechanical ventilation in children with ARDS, to provide evidence to the treatment and care of children with ARDS.MethodsWe searched the Pubmed et al. databases by computer until January 23, 2024 for randomized controlled trials (RCTs) on the role of prone position in the mechanical ventilation in children with ARDS. We evaluated the quality of included studies according to the quality evaluation criteria recommended by the Cochrane library. RevMan 5.3 software was used for meta-analysis.Results7 RCTs involving 433 children with ARDS were included. Meta-analysis indicated that prone position is beneficial to improve the arterial oxygenation pressure [MD = 4.27 mmHg, 95% CI (3.49, 5.06)], PaO2/FiO2 [MD = 26.97, 95% CI (19.17, 34.77)], reduced the oxygenation index [MD = −3.52, 95% CI (−5.41, −1.64)], mean airway pressure [MD = −1.91 cmH2O, 95% CI (−2.27, −1.55)] and mortality [OR = 0.33, 95% CI (0.15, 0.73), all P < 0.05]. There were no statistical differences in the duration of mechanical ventilation between the prone position group and control group [MD = −17.01, 97.27, 95% CI (−38.28, 4.26), P = 0.12]. Egger test results showed that no significant publication bias was found (all P > 0.05).ConclusionsProne position ventilation has obvious advantages in improving oxygenation, but there is no significant improvement in the time of mechanical ventilation in the treatment of children with ARDS. In the future, more large-sample, high-quality RCTs are still needed to further analyze the role of prone position in the mechanical ventilation in children with ARDS.https://www.frontiersin.org/articles/10.3389/fped.2024.1293453/fullprone positionmechanical ventilationchildrenacute respiratory distress syndrometreatmentcare |
| spellingShingle | Wen Qin Lei Mao Yue Shen Li Zhao Prone position in the mechanical ventilation of acute respiratory distress syndrome children: a systematic review and meta-analysis Frontiers in Pediatrics prone position mechanical ventilation children acute respiratory distress syndrome treatment care |
| title | Prone position in the mechanical ventilation of acute respiratory distress syndrome children: a systematic review and meta-analysis |
| title_full | Prone position in the mechanical ventilation of acute respiratory distress syndrome children: a systematic review and meta-analysis |
| title_fullStr | Prone position in the mechanical ventilation of acute respiratory distress syndrome children: a systematic review and meta-analysis |
| title_full_unstemmed | Prone position in the mechanical ventilation of acute respiratory distress syndrome children: a systematic review and meta-analysis |
| title_short | Prone position in the mechanical ventilation of acute respiratory distress syndrome children: a systematic review and meta-analysis |
| title_sort | prone position in the mechanical ventilation of acute respiratory distress syndrome children a systematic review and meta analysis |
| topic | prone position mechanical ventilation children acute respiratory distress syndrome treatment care |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1293453/full |
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