Administration of <i>Ligilactobacillus salivarius</i> MP101 in an Elderly Nursing Home during the COVID-19 Pandemic: Immunological and Nutritional Impact
The elderly population living in nursing homes is particularly vulnerable to COVID-19 although individual susceptibility to SARS-CoV-2 infection may be related to the host microbiota. The objective of this work was to investigate the effect of <i>Ligilactobacillus salivarius</i> MP101 on...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/10/9/2149 |
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| author | Marta Mozota Irma Castro Natalia Gómez-Torres Rebeca Arroyo Yolanda Lailla Mario Somada Claudio Alba Juan Miguel Rodríguez |
| author_facet | Marta Mozota Irma Castro Natalia Gómez-Torres Rebeca Arroyo Yolanda Lailla Mario Somada Claudio Alba Juan Miguel Rodríguez |
| author_sort | Marta Mozota |
| collection | DOAJ |
| description | The elderly population living in nursing homes is particularly vulnerable to COVID-19 although individual susceptibility to SARS-CoV-2 infection may be related to the host microbiota. The objective of this work was to investigate the effect of <i>Ligilactobacillus salivarius</i> MP101 on the functional (Barthel index), cognitive (GDS/FAST), and nutritional (MNA) status as well as on the nasal and fecal inflammatory profiles of elderly residents living in a nursing home that is highly affected by COVID-19. A total of 25 residents participated in the trial, which involved the daily ingestion of a dairy product (<i>L. salivarius</i> MP101: 9.3 log<sub>10</sub> CFU per unit) for 4 months. Nasal and fecal samples were analyzed for 37 immune factors at recruitment and at the end of the study. After the trial, no change in the GDS/FAST scores were found but, in contrast, the values for the Barthel index and the MNA score improved significantly. The concentrations of some immune factors changed significantly after the trial, including a decrease in the concentrations of BAFF/TNFSF13B, APRIL/TNFSF13, IL8, IL31, osteopontin, sTNF-R1, and sTNF-R2, and an increase in chitinase 3-like 1, IL19, IL35, and pentraxin 3 was also observed. In conclusion, <i>L. salivarius</i> MP101 seems to be a promising strain for improving or maintaining health in this highly vulnerable population. |
| first_indexed | 2024-03-10T07:40:28Z |
| format | Article |
| id | doaj.art-3e50194a17c64950a5f3e742068328c8 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T07:40:28Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-3e50194a17c64950a5f3e742068328c82023-11-22T13:04:58ZengMDPI AGFoods2304-81582021-09-01109214910.3390/foods10092149Administration of <i>Ligilactobacillus salivarius</i> MP101 in an Elderly Nursing Home during the COVID-19 Pandemic: Immunological and Nutritional ImpactMarta Mozota0Irma Castro1Natalia Gómez-Torres2Rebeca Arroyo3Yolanda Lailla4Mario Somada5Claudio Alba6Juan Miguel Rodríguez7Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, SpainVilla Villera, 22142 Sieso de Huesca, SpainVilla Villera, 22142 Sieso de Huesca, SpainDepartment of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, SpainThe elderly population living in nursing homes is particularly vulnerable to COVID-19 although individual susceptibility to SARS-CoV-2 infection may be related to the host microbiota. The objective of this work was to investigate the effect of <i>Ligilactobacillus salivarius</i> MP101 on the functional (Barthel index), cognitive (GDS/FAST), and nutritional (MNA) status as well as on the nasal and fecal inflammatory profiles of elderly residents living in a nursing home that is highly affected by COVID-19. A total of 25 residents participated in the trial, which involved the daily ingestion of a dairy product (<i>L. salivarius</i> MP101: 9.3 log<sub>10</sub> CFU per unit) for 4 months. Nasal and fecal samples were analyzed for 37 immune factors at recruitment and at the end of the study. After the trial, no change in the GDS/FAST scores were found but, in contrast, the values for the Barthel index and the MNA score improved significantly. The concentrations of some immune factors changed significantly after the trial, including a decrease in the concentrations of BAFF/TNFSF13B, APRIL/TNFSF13, IL8, IL31, osteopontin, sTNF-R1, and sTNF-R2, and an increase in chitinase 3-like 1, IL19, IL35, and pentraxin 3 was also observed. In conclusion, <i>L. salivarius</i> MP101 seems to be a promising strain for improving or maintaining health in this highly vulnerable population.https://www.mdpi.com/2304-8158/10/9/2149probiotics<i>Ligilactobacillus salivarius</i>elderlynursing homeCOVID-19 |
| spellingShingle | Marta Mozota Irma Castro Natalia Gómez-Torres Rebeca Arroyo Yolanda Lailla Mario Somada Claudio Alba Juan Miguel Rodríguez Administration of <i>Ligilactobacillus salivarius</i> MP101 in an Elderly Nursing Home during the COVID-19 Pandemic: Immunological and Nutritional Impact Foods probiotics <i>Ligilactobacillus salivarius</i> elderly nursing home COVID-19 |
| title | Administration of <i>Ligilactobacillus salivarius</i> MP101 in an Elderly Nursing Home during the COVID-19 Pandemic: Immunological and Nutritional Impact |
| title_full | Administration of <i>Ligilactobacillus salivarius</i> MP101 in an Elderly Nursing Home during the COVID-19 Pandemic: Immunological and Nutritional Impact |
| title_fullStr | Administration of <i>Ligilactobacillus salivarius</i> MP101 in an Elderly Nursing Home during the COVID-19 Pandemic: Immunological and Nutritional Impact |
| title_full_unstemmed | Administration of <i>Ligilactobacillus salivarius</i> MP101 in an Elderly Nursing Home during the COVID-19 Pandemic: Immunological and Nutritional Impact |
| title_short | Administration of <i>Ligilactobacillus salivarius</i> MP101 in an Elderly Nursing Home during the COVID-19 Pandemic: Immunological and Nutritional Impact |
| title_sort | administration of i ligilactobacillus salivarius i mp101 in an elderly nursing home during the covid 19 pandemic immunological and nutritional impact |
| topic | probiotics <i>Ligilactobacillus salivarius</i> elderly nursing home COVID-19 |
| url | https://www.mdpi.com/2304-8158/10/9/2149 |
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