IARC 2019: “Night shift work” is probably carcinogenic: What about disturbed chronobiology in all walks of life?
Abstract In June of 2019, a working group convened by the International Agency for Research on Cancer [IARC] concluded that “night shift work” is probably carcinogenic to humans (a Group 2A carcinogen). This was based on sufficient evidence of cancer and strong mechanistic evidence in experimental a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | Journal of Occupational Medicine and Toxicology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12995-019-0249-6 |
| _version_ | 1798024339727056896 |
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| author | Thomas C. Erren Peter Morfeld J. Valérie Groß Ursula Wild Philip Lewis |
| author_facet | Thomas C. Erren Peter Morfeld J. Valérie Groß Ursula Wild Philip Lewis |
| author_sort | Thomas C. Erren |
| collection | DOAJ |
| description | Abstract In June of 2019, a working group convened by the International Agency for Research on Cancer [IARC] concluded that “night shift work” is probably carcinogenic to humans (a Group 2A carcinogen). This was based on sufficient evidence of cancer and strong mechanistic evidence in experimental animals and limited evidence from human epidemiological studies. The biological basis from experimental work is clear and compelling: Disturbed chronobiology such as due to alterations in the light-dark schedule which shift-workers experience is associated with carcinogenicity. But is it correct to assume in epidemiological studies that “night shift work” provides the same dose of disturbed chronobiology to all night workers and that disturbed chronobiology from activities outside of work does not count? Both chronobiological theory and supporting evidence suggest that much-needed future epidemiology should address these questions and should consider disturbed chronobiology in all walks of life. |
| first_indexed | 2024-04-11T18:00:48Z |
| format | Article |
| id | doaj.art-3e54625b99394e4093d8a9e11729cdcd |
| institution | Directory Open Access Journal |
| issn | 1745-6673 |
| language | English |
| last_indexed | 2024-04-11T18:00:48Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Occupational Medicine and Toxicology |
| spelling | doaj.art-3e54625b99394e4093d8a9e11729cdcd2022-12-22T04:10:29ZengBMCJournal of Occupational Medicine and Toxicology1745-66732019-11-011411310.1186/s12995-019-0249-6IARC 2019: “Night shift work” is probably carcinogenic: What about disturbed chronobiology in all walks of life?Thomas C. Erren0Peter MorfeldJ. Valérie Groß1Ursula Wild2Philip Lewis3Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research, University Hospital of CologneInstitute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research, University Hospital of CologneInstitute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research, University Hospital of CologneInstitute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research, University Hospital of CologneAbstract In June of 2019, a working group convened by the International Agency for Research on Cancer [IARC] concluded that “night shift work” is probably carcinogenic to humans (a Group 2A carcinogen). This was based on sufficient evidence of cancer and strong mechanistic evidence in experimental animals and limited evidence from human epidemiological studies. The biological basis from experimental work is clear and compelling: Disturbed chronobiology such as due to alterations in the light-dark schedule which shift-workers experience is associated with carcinogenicity. But is it correct to assume in epidemiological studies that “night shift work” provides the same dose of disturbed chronobiology to all night workers and that disturbed chronobiology from activities outside of work does not count? Both chronobiological theory and supporting evidence suggest that much-needed future epidemiology should address these questions and should consider disturbed chronobiology in all walks of life.http://link.springer.com/article/10.1186/s12995-019-0249-6Night workShift workCircadianChronodisruptionCancerBreast |
| spellingShingle | Thomas C. Erren Peter Morfeld J. Valérie Groß Ursula Wild Philip Lewis IARC 2019: “Night shift work” is probably carcinogenic: What about disturbed chronobiology in all walks of life? Journal of Occupational Medicine and Toxicology Night work Shift work Circadian Chronodisruption Cancer Breast |
| title | IARC 2019: “Night shift work” is probably carcinogenic: What about disturbed chronobiology in all walks of life? |
| title_full | IARC 2019: “Night shift work” is probably carcinogenic: What about disturbed chronobiology in all walks of life? |
| title_fullStr | IARC 2019: “Night shift work” is probably carcinogenic: What about disturbed chronobiology in all walks of life? |
| title_full_unstemmed | IARC 2019: “Night shift work” is probably carcinogenic: What about disturbed chronobiology in all walks of life? |
| title_short | IARC 2019: “Night shift work” is probably carcinogenic: What about disturbed chronobiology in all walks of life? |
| title_sort | iarc 2019 night shift work is probably carcinogenic what about disturbed chronobiology in all walks of life |
| topic | Night work Shift work Circadian Chronodisruption Cancer Breast |
| url | http://link.springer.com/article/10.1186/s12995-019-0249-6 |
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