Prognostic Potential of Heart Rate and Hypertension in Multiple Myeloma Patients
Background: The prognosis of patients with multiple myeloma (MM) is variable and partly depends on their cardiovascular status. The presence of arrhythmias can lead to worse outcomes. Therefore, this study aimed to evaluate the potential of heart rate (HR) and hypertension in predicating the outcome...
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.681484/full |
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| author | Jie Wang Jie Wang Manyun Tang Yunxiang Long Jingzhuo Song Limei Chen Mengchang Wang Yongxin Li Chaofeng Sun Yang Yan |
| author_facet | Jie Wang Jie Wang Manyun Tang Yunxiang Long Jingzhuo Song Limei Chen Mengchang Wang Yongxin Li Chaofeng Sun Yang Yan |
| author_sort | Jie Wang |
| collection | DOAJ |
| description | Background: The prognosis of patients with multiple myeloma (MM) is variable and partly depends on their cardiovascular status. The presence of arrhythmias can lead to worse outcomes. Therefore, this study aimed to evaluate the potential of heart rate (HR) and hypertension in predicating the outcomes of MM patients.Methods: This study retrospectively enrolled patients with MM between January 1, 2010, and December 31, 2018, at the First Affiliated Hospital of Xi'an Jiaotong University. The endpoint was all-cause mortality. The Pearson's chi-square test was used to assess the association between hypertension and outcomes. Univariate and multivariate Cox proportional hazards models were developed to evaluate the relationship between HR and all-cause mortality.Results: A total of 386 patients were included. The mean HR was 83.8 ± 23.1 beats per minute (bpm). Patients with HR >100 bpm had a higher all-cause mortality (79.4%, 50/63) than those with 60 ≤ HR ≤ 100 bpm (39.9%, 110/276) and <60 bpm (19.1%, 9/47) (p < 0.001). Subgroup analysis based on the International Staging System and sex revealed similar relationships (p < 0.01). When stratified by age, patients with HR >100 bpm had higher all-cause mortality than those with a lower HR when age was <65 years or 65–75 years (p < 0.001) but not >75 years. The proportion of patients with hypertension was 54.7% (211/386). However, hypertension was not associated with all-cause mortality in MM patients (χ2=1.729, p > 0.05). MM patients with HR >100 bpm had the highest all-cause mortality.Conclusions: The prognostic potential of HR may be useful in aiding risk stratification and promoting the management of these patients. |
| first_indexed | 2024-12-17T20:09:46Z |
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| id | doaj.art-3e5515d17ba040b4a23ed0cdf8d31384 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-17T20:09:46Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-3e5515d17ba040b4a23ed0cdf8d313842022-12-21T21:34:14ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-09-01810.3389/fcvm.2021.681484681484Prognostic Potential of Heart Rate and Hypertension in Multiple Myeloma PatientsJie Wang0Jie Wang1Manyun Tang2Yunxiang Long3Jingzhuo Song4Limei Chen5Mengchang Wang6Yongxin Li7Chaofeng Sun8Yang Yan9Atrial Fibrillation Centre and Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaAtrial Fibrillation Centre and Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Cardiovascular Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaAtrial Fibrillation Centre and Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Cardiovascular Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaBackground: The prognosis of patients with multiple myeloma (MM) is variable and partly depends on their cardiovascular status. The presence of arrhythmias can lead to worse outcomes. Therefore, this study aimed to evaluate the potential of heart rate (HR) and hypertension in predicating the outcomes of MM patients.Methods: This study retrospectively enrolled patients with MM between January 1, 2010, and December 31, 2018, at the First Affiliated Hospital of Xi'an Jiaotong University. The endpoint was all-cause mortality. The Pearson's chi-square test was used to assess the association between hypertension and outcomes. Univariate and multivariate Cox proportional hazards models were developed to evaluate the relationship between HR and all-cause mortality.Results: A total of 386 patients were included. The mean HR was 83.8 ± 23.1 beats per minute (bpm). Patients with HR >100 bpm had a higher all-cause mortality (79.4%, 50/63) than those with 60 ≤ HR ≤ 100 bpm (39.9%, 110/276) and <60 bpm (19.1%, 9/47) (p < 0.001). Subgroup analysis based on the International Staging System and sex revealed similar relationships (p < 0.01). When stratified by age, patients with HR >100 bpm had higher all-cause mortality than those with a lower HR when age was <65 years or 65–75 years (p < 0.001) but not >75 years. The proportion of patients with hypertension was 54.7% (211/386). However, hypertension was not associated with all-cause mortality in MM patients (χ2=1.729, p > 0.05). MM patients with HR >100 bpm had the highest all-cause mortality.Conclusions: The prognostic potential of HR may be useful in aiding risk stratification and promoting the management of these patients.https://www.frontiersin.org/articles/10.3389/fcvm.2021.681484/fullmultiple myelomarisk stratificationheart ratehypertensioncardiac rhythm abnormalities |
| spellingShingle | Jie Wang Jie Wang Manyun Tang Yunxiang Long Jingzhuo Song Limei Chen Mengchang Wang Yongxin Li Chaofeng Sun Yang Yan Prognostic Potential of Heart Rate and Hypertension in Multiple Myeloma Patients Frontiers in Cardiovascular Medicine multiple myeloma risk stratification heart rate hypertension cardiac rhythm abnormalities |
| title | Prognostic Potential of Heart Rate and Hypertension in Multiple Myeloma Patients |
| title_full | Prognostic Potential of Heart Rate and Hypertension in Multiple Myeloma Patients |
| title_fullStr | Prognostic Potential of Heart Rate and Hypertension in Multiple Myeloma Patients |
| title_full_unstemmed | Prognostic Potential of Heart Rate and Hypertension in Multiple Myeloma Patients |
| title_short | Prognostic Potential of Heart Rate and Hypertension in Multiple Myeloma Patients |
| title_sort | prognostic potential of heart rate and hypertension in multiple myeloma patients |
| topic | multiple myeloma risk stratification heart rate hypertension cardiac rhythm abnormalities |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.681484/full |
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