Bronchoalveolar lavage cellular analyses in conjunction with high-resolution computed tomography imaging as a diagnostic intervention for patients with suspected interstitial lung disease
Background: Bronchoalveolar lavage (BAL) has gained acceptance for diagnosis of Interstitial lung disease (ILD). The advent of high-resolution computed tomography (HRCT) has reduced the clinical utility of BAL. This work has utilized the recommendations of the American Thoracic Society (ATS) to opti...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Lung India |
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| Online Access: | http://www.lungindia.com/article.asp?issn=0970-2113;year=2016;volume=33;issue=3;spage=287;epage=291;aulast=Chockalingam |
| _version_ | 1819240863166889984 |
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| author | Ammaiyappan Chockalingam Ranganathan Duraiswamy Madhavan Jagadeesan |
| author_facet | Ammaiyappan Chockalingam Ranganathan Duraiswamy Madhavan Jagadeesan |
| author_sort | Ammaiyappan Chockalingam |
| collection | DOAJ |
| description | Background: Bronchoalveolar lavage (BAL) has gained acceptance for diagnosis of Interstitial lung disease (ILD). The advent of high-resolution computed tomography (HRCT) has reduced the clinical utility of BAL. This work has utilized the recommendations of the American Thoracic Society (ATS) to optimize BAL and the findings have been associated with clinical examination and HRCT to precisely narrow down the cause of ILD. Materials and Methods: BAL was performed on ILD suspects at the target site chosen based on HRCT. The procedure, transport, processing, and analysis of BAL fluid were performed as per the ATS guidelines. The clinical data, HRCT findings and BAL report were used to narrow down the diagnosis of ILD. The statistical analysis was performed to assess the significance. Results: The BAL procedure was optimized as per the recommendations of the ATS. In a cohort of 50 patients, Idiopathic pulmonary fibrosis, (8) hypersensitivity pneumonitis, (17) connective tissue disorder, (9) sarcoidosis, (3) pneumoconiosis, (5) acute respiratory distress syndrome, (2) eosinophilic lung disease (2) and lymphangitic carcinomatosa, (2) aspiration bronchiolitis (1) and pulmonary histiocytosis (1) were diagnosed. Statistically significant variation in differential counts was found in different ILDs. The different ILDs were classified based on the criteria described by the ATS. Clinical Significance: BAL along with clinical and HRCT findings improved the diagnostic accuracy by incorporating, the acute or chronic nature of the disease and the cause for acute exacerbation, which helped in the better management of ILDs. |
| first_indexed | 2024-12-23T14:14:46Z |
| format | Article |
| id | doaj.art-3e560d835d164d2cb1e9af9ba8fa0d15 |
| institution | Directory Open Access Journal |
| issn | 0970-2113 0974-598X |
| language | English |
| last_indexed | 2024-12-23T14:14:46Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Lung India |
| spelling | doaj.art-3e560d835d164d2cb1e9af9ba8fa0d152022-12-21T17:43:57ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2016-01-0133328729110.4103/0970-2113.180806Bronchoalveolar lavage cellular analyses in conjunction with high-resolution computed tomography imaging as a diagnostic intervention for patients with suspected interstitial lung diseaseAmmaiyappan ChockalingamRanganathan DuraiswamyMadhavan JagadeesanBackground: Bronchoalveolar lavage (BAL) has gained acceptance for diagnosis of Interstitial lung disease (ILD). The advent of high-resolution computed tomography (HRCT) has reduced the clinical utility of BAL. This work has utilized the recommendations of the American Thoracic Society (ATS) to optimize BAL and the findings have been associated with clinical examination and HRCT to precisely narrow down the cause of ILD. Materials and Methods: BAL was performed on ILD suspects at the target site chosen based on HRCT. The procedure, transport, processing, and analysis of BAL fluid were performed as per the ATS guidelines. The clinical data, HRCT findings and BAL report were used to narrow down the diagnosis of ILD. The statistical analysis was performed to assess the significance. Results: The BAL procedure was optimized as per the recommendations of the ATS. In a cohort of 50 patients, Idiopathic pulmonary fibrosis, (8) hypersensitivity pneumonitis, (17) connective tissue disorder, (9) sarcoidosis, (3) pneumoconiosis, (5) acute respiratory distress syndrome, (2) eosinophilic lung disease (2) and lymphangitic carcinomatosa, (2) aspiration bronchiolitis (1) and pulmonary histiocytosis (1) were diagnosed. Statistically significant variation in differential counts was found in different ILDs. The different ILDs were classified based on the criteria described by the ATS. Clinical Significance: BAL along with clinical and HRCT findings improved the diagnostic accuracy by incorporating, the acute or chronic nature of the disease and the cause for acute exacerbation, which helped in the better management of ILDs.http://www.lungindia.com/article.asp?issn=0970-2113;year=2016;volume=33;issue=3;spage=287;epage=291;aulast=ChockalingamATS recommendationsbronchoalveolar lavageInterstitial lung diseases |
| spellingShingle | Ammaiyappan Chockalingam Ranganathan Duraiswamy Madhavan Jagadeesan Bronchoalveolar lavage cellular analyses in conjunction with high-resolution computed tomography imaging as a diagnostic intervention for patients with suspected interstitial lung disease Lung India ATS recommendations bronchoalveolar lavage Interstitial lung diseases |
| title | Bronchoalveolar lavage cellular analyses in conjunction with high-resolution computed tomography imaging as a diagnostic intervention for patients with suspected interstitial lung disease |
| title_full | Bronchoalveolar lavage cellular analyses in conjunction with high-resolution computed tomography imaging as a diagnostic intervention for patients with suspected interstitial lung disease |
| title_fullStr | Bronchoalveolar lavage cellular analyses in conjunction with high-resolution computed tomography imaging as a diagnostic intervention for patients with suspected interstitial lung disease |
| title_full_unstemmed | Bronchoalveolar lavage cellular analyses in conjunction with high-resolution computed tomography imaging as a diagnostic intervention for patients with suspected interstitial lung disease |
| title_short | Bronchoalveolar lavage cellular analyses in conjunction with high-resolution computed tomography imaging as a diagnostic intervention for patients with suspected interstitial lung disease |
| title_sort | bronchoalveolar lavage cellular analyses in conjunction with high resolution computed tomography imaging as a diagnostic intervention for patients with suspected interstitial lung disease |
| topic | ATS recommendations bronchoalveolar lavage Interstitial lung diseases |
| url | http://www.lungindia.com/article.asp?issn=0970-2113;year=2016;volume=33;issue=3;spage=287;epage=291;aulast=Chockalingam |
| work_keys_str_mv | AT ammaiyappanchockalingam bronchoalveolarlavagecellularanalysesinconjunctionwithhighresolutioncomputedtomographyimagingasadiagnosticinterventionforpatientswithsuspectedinterstitiallungdisease AT ranganathanduraiswamy bronchoalveolarlavagecellularanalysesinconjunctionwithhighresolutioncomputedtomographyimagingasadiagnosticinterventionforpatientswithsuspectedinterstitiallungdisease AT madhavanjagadeesan bronchoalveolarlavagecellularanalysesinconjunctionwithhighresolutioncomputedtomographyimagingasadiagnosticinterventionforpatientswithsuspectedinterstitiallungdisease |