Development of a Sildenafil Citrate Microemulsion-Loaded Hydrogel as a Potential System for Drug Delivery to the Penis and Its Cellular Metabolic Mechanism

Development of a Sildenafil Citrate Microemulsion-Loaded Hydrogel as a Potential System for Drug Delivery to the Penis and Its Cellular Metabolic Mechanism

Sildenafil citrate is used to treat mild to moderate erectile dysfunction and premature ejaculation. However, it has low oral bioavailability, numerous adverse effects, and delayed onset of action. These problems may be resolved by transdermal delivery to the penis. Hence, sildenafil citrate was for...

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Bibliographic Details
Main Authors: Apichart Atipairin, Charisopon Chunhachaichana, Titpawan Nakpheng, Narumon Changsan, Teerapol Srichana, Somchai Sawatdee
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceutics
Subjects:
sildenafil citrate
microemulsion
hydrogel
skin permeation
stability
metabolism
Online Access:https://www.mdpi.com/1999-4923/12/11/1055

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