Age-dependent involvement of gut mast cells and histamine in post-stroke inflammation

Age-dependent involvement of gut mast cells and histamine in post-stroke inflammation

Abstract Background Risk of stroke-related morbidity and mortality increases significantly with age. Aging is associated with chronic, low-grade inflammation, which is thought to contribute to the poorer outcomes after stroke seen in the elderly. Histamine (HA) is a major molecular mediator of infla...

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Main Authors: Maria Pilar Blasco, Anjali Chauhan, Pedram Honarpisheh, Hilda Ahnstedt, John d’Aigle, Arunkumar Ganesan, Sriram Ayyaswamy, Frank Blixt, Susan Venable, Angela Major, David Durgan, Anthony Haag, Julia Kofler, Robert Bryan, Louise D. McCullough, Bhanu Priya Ganesh
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Neuroinflammation
Subjects:
Mast cells
Histamine
Histamine receptor
Cytokines
Post-stroke
Microbiome
Online Access:http://link.springer.com/article/10.1186/s12974-020-01833-1

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