Case Report: Diagnosis of Acute Q Fever With Aseptic Meningitis in a Patient by Using Metagenomic Next-Generation Sequencing
Query fever (Q fever) is a widespread zoonotic disease caused by the bacterium of Coxiella burnetii (C. burnetii). Its neurological complications are rarely reported. But they may lead to severe consequences. It needs a rapid and accurate detective method to diagnose acute Q fever with neurological...
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.855020/full |
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| author | Meifeng Gu Xiaoqin Mo Zhenchu Tang Zhenchu Tang Jianguang Tang Wei Wang |
| author_facet | Meifeng Gu Xiaoqin Mo Zhenchu Tang Zhenchu Tang Jianguang Tang Wei Wang |
| author_sort | Meifeng Gu |
| collection | DOAJ |
| description | Query fever (Q fever) is a widespread zoonotic disease caused by the bacterium of Coxiella burnetii (C. burnetii). Its neurological complications are rarely reported. But they may lead to severe consequences. It needs a rapid and accurate detective method to diagnose acute Q fever with neurological presentations in non-epidemic areas urgently. Here, we report an acute Q fever case with aseptic meningitis. The male patient, without any contact history in the epidemic area or with animals, was indicated to exhibit fever and headache symptoms. The cultures of blood, stool, urine, and sputum were all negative. But C. burnetii was repeatedly detected in blood by metagenomic next-generation sequencing (mNGS). He received Doxycycline therapy and quickly returned to normal. Therefore, for the diagnosis and identification of Q fever in non-reporting regions, mNGS has comparative advantages. Secondly, aseptic meningitis may be a direct infection of C. burnetii to central nervous system (CNS) or inflammatory reactions to systemic infection, we recommend detecting mNGS both in blood and cerebrospinal fluid (CSF). |
| first_indexed | 2024-12-12T04:53:02Z |
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| id | doaj.art-3e59054ad5474b02a9787d1a8c507cef |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-12T04:53:02Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj.art-3e59054ad5474b02a9787d1a8c507cef2022-12-22T00:37:26ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-05-01910.3389/fmed.2022.855020855020Case Report: Diagnosis of Acute Q Fever With Aseptic Meningitis in a Patient by Using Metagenomic Next-Generation SequencingMeifeng Gu0Xiaoqin Mo1Zhenchu Tang2Zhenchu Tang3Jianguang Tang4Wei Wang5Department of Neurology, the Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, the Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, the Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Tumor Models and Individualized Medicine, the Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, the Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, the Second Xiangya Hospital, Central South University, Changsha, ChinaQuery fever (Q fever) is a widespread zoonotic disease caused by the bacterium of Coxiella burnetii (C. burnetii). Its neurological complications are rarely reported. But they may lead to severe consequences. It needs a rapid and accurate detective method to diagnose acute Q fever with neurological presentations in non-epidemic areas urgently. Here, we report an acute Q fever case with aseptic meningitis. The male patient, without any contact history in the epidemic area or with animals, was indicated to exhibit fever and headache symptoms. The cultures of blood, stool, urine, and sputum were all negative. But C. burnetii was repeatedly detected in blood by metagenomic next-generation sequencing (mNGS). He received Doxycycline therapy and quickly returned to normal. Therefore, for the diagnosis and identification of Q fever in non-reporting regions, mNGS has comparative advantages. Secondly, aseptic meningitis may be a direct infection of C. burnetii to central nervous system (CNS) or inflammatory reactions to systemic infection, we recommend detecting mNGS both in blood and cerebrospinal fluid (CSF).https://www.frontiersin.org/articles/10.3389/fmed.2022.855020/fullQ feverCoxiella burnetiifebrile illnessneurological complicationsmetagenomic next-generation sequencing (mNGS)diagnostic technique |
| spellingShingle | Meifeng Gu Xiaoqin Mo Zhenchu Tang Zhenchu Tang Jianguang Tang Wei Wang Case Report: Diagnosis of Acute Q Fever With Aseptic Meningitis in a Patient by Using Metagenomic Next-Generation Sequencing Frontiers in Medicine Q fever Coxiella burnetii febrile illness neurological complications metagenomic next-generation sequencing (mNGS) diagnostic technique |
| title | Case Report: Diagnosis of Acute Q Fever With Aseptic Meningitis in a Patient by Using Metagenomic Next-Generation Sequencing |
| title_full | Case Report: Diagnosis of Acute Q Fever With Aseptic Meningitis in a Patient by Using Metagenomic Next-Generation Sequencing |
| title_fullStr | Case Report: Diagnosis of Acute Q Fever With Aseptic Meningitis in a Patient by Using Metagenomic Next-Generation Sequencing |
| title_full_unstemmed | Case Report: Diagnosis of Acute Q Fever With Aseptic Meningitis in a Patient by Using Metagenomic Next-Generation Sequencing |
| title_short | Case Report: Diagnosis of Acute Q Fever With Aseptic Meningitis in a Patient by Using Metagenomic Next-Generation Sequencing |
| title_sort | case report diagnosis of acute q fever with aseptic meningitis in a patient by using metagenomic next generation sequencing |
| topic | Q fever Coxiella burnetii febrile illness neurological complications metagenomic next-generation sequencing (mNGS) diagnostic technique |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.855020/full |
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