APPLICATION OF LIQUID-BASED CYTOLOGY IN DIAGNOSING CERVICAL PATHOLOGY
Objective – to study the advantages of liquid-based cytology in comparison with Pap-testin early diagnosis of cervical cancer. Materials and methods: The clinical records of 46 women of reproductive age were analysed. The women had applied to antenatal clinic in Clinical Policlinic N 20 for routine...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
The Publishing House Medicine and Enlightenment
2018-09-01
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| Series: | Мать и дитя в Кузбассе |
| Subjects: | |
| Online Access: | http://mednauki.ru/index.php/MD/article/view/270 |
| Summary: | Objective – to study the advantages of liquid-based cytology in comparison with Pap-testin early diagnosis of cervical cancer.
Materials and methods: The clinical records of 46 women of reproductive age were analysed. The women had applied to antenatal clinic in Clinical Policlinic N 20 for routine examination and were studied by clinical, laboratory, statistical methods.
All women underwent cytological screening both with a technology such as the PAP test and a liquid-based one.
Results: The results of cytological screening by the PAP-test showed: the normal findings in 25 women (54.3 %); inflammatory type – in 18 (39.1 %). Three women had inadequate material sampling.
The results of cytological screening by liquid-based cytology showed: negative result – in 22 women (47.8 %); cytogram within normal limits (smear showed inflammatory process) – in 18 women (39.1 %); atypical squamous cells of undetermined significance – in 5 women (10.9 %); low degree of epithelial squamous lesions – in 1 woman (2,2 %).
The sensitivity of liquid-based cytology was 74.0 % while that of the Pap-test – 31.0 %.The specificity of liquid-based cytology(73.0 %) was lower than that of the PAP-test (86.0 %). The prognostic value of the positive result of the liquid-based cytology test (86.0 %) was identical to the PAP-test (85.0 %) prognostic value. However, the prognostic value of the negative result of the liquid-based cytology test (55.0 %) was much higher than that of the PAP-test (33.0 %).
Conclusion: Analyzing the results received it can be concluded that the liquid-based cytology makes it more likely to give a positive result in women who really have some disease, and to a lesser extent – in those who have no disease. Both screening methods have similar capacity to predict a disease. However, the prognosis of the probability of none disease in women with a negative result is higher with liquid-based cytology.
The method of cytological investigation – liquid cytology of the cervix – allows to obtain the most accurate result of the study of cells for the presence or absence of pathology and is highly effective for the detection of atypical and cancer cells. |
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| ISSN: | 1991-010X 2542-0968 |