Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved]
B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2018-04-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/7-429/v1 |
| _version_ | 1819009424889479168 |
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| author | Juan Carlos Yam-Puc Lingling Zhang Yang Zhang Kai-Michael Toellner |
| author_facet | Juan Carlos Yam-Puc Lingling Zhang Yang Zhang Kai-Michael Toellner |
| author_sort | Juan Carlos Yam-Puc |
| collection | DOAJ |
| description | B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells. Furthermore, we discuss BCR-derived signals on activated B cells that lead to germinal center and plasma cell differentiation. |
| first_indexed | 2024-12-21T00:56:09Z |
| format | Article |
| id | doaj.art-3e5e95e9b1414aa891752f528caac417 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-21T00:56:09Z |
| publishDate | 2018-04-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-3e5e95e9b1414aa891752f528caac4172022-12-21T19:21:18ZengF1000 Research LtdF1000Research2046-14022018-04-01710.12688/f1000research.13567.114737Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved]Juan Carlos Yam-Puc0Lingling Zhang1Yang Zhang2Kai-Michael Toellner3Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKInstitute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKB-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells. Furthermore, we discuss BCR-derived signals on activated B cells that lead to germinal center and plasma cell differentiation.https://f1000research.com/articles/7-429/v1 |
| spellingShingle | Juan Carlos Yam-Puc Lingling Zhang Yang Zhang Kai-Michael Toellner Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved] F1000Research |
| title | Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved] |
| title_full | Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved] |
| title_fullStr | Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved] |
| title_full_unstemmed | Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved] |
| title_short | Role of B-cell receptors for B-cell development and antigen-induced differentiation [version 1; referees: 2 approved] |
| title_sort | role of b cell receptors for b cell development and antigen induced differentiation version 1 referees 2 approved |
| url | https://f1000research.com/articles/7-429/v1 |
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