Impact of epidermal growth factor receptor gene RS1468727 polymorphism on survival of the patients with oral squamous cell carcinoma
Introduction/Objective. Genetic aberrations and environmental factors are known to play an important role in oral squamous cell carcinoma (OSCC). The aim of the study was to clarify the association of epidermal growth factor receptor (EGFR) gene polymorphism rs1468727 with overall survival (OS) in...
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| Format: | Article |
| Language: | English |
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Serbian Medical Society
2023-01-01
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| Series: | Srpski Arhiv za Celokupno Lekarstvo |
| Subjects: | |
| Online Access: | https://doiserbia.nb.rs/img/doi/0370-8179/2023/0370-81792300076B.pdf |
| _version_ | 1827586737201741824 |
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| author | Bačulov Katarina Đan Mihajla Bajkin Branislav Mijatov Ivana Vučković Nada Mijatov Saša Đan Igor Barjaktarović Iva Stojčević-Maletić Jelena Vučinić Nataša |
| author_facet | Bačulov Katarina Đan Mihajla Bajkin Branislav Mijatov Ivana Vučković Nada Mijatov Saša Đan Igor Barjaktarović Iva Stojčević-Maletić Jelena Vučinić Nataša |
| author_sort | Bačulov Katarina |
| collection | DOAJ |
| description | Introduction/Objective. Genetic aberrations and environmental factors are known to play an important role in oral squamous cell carcinoma (OSCC). The aim of the study was to clarify the association of epidermal growth factor receptor (EGFR) gene polymorphism rs1468727 with overall survival (OS) in patients with OSCC. Methods. The study comprised a total of 61 patients diagnosed with OSCC. The follow-up period for each patient was three years from the date of surgery and during that period their genotypes for rs1468727 polymorphism of the EGFR gene were identified using real-time polymerase chain reaction. Binary logistic regression was used to investigate the influence of various variables on survival. Additionally, the χ2 test of independence and Man–Whitney U test were done to examine the interplay between two categorical variables and two independent samples. Results. Two variables demonstrated a statistically significant influence on OS: the TNM Classification of Malignant Tumors (TNM) stage and EGFR genotype. At the end of the follow-up period, 39 patients survived, with a noteworthy observation that more than half of the survivors had the EGFR rs1468727 CC genotype. The distribution of CC and CT genotypes was equal (χ2 = 0.397, df = 2, p = 0.820) among patients who deceased, indicating that no statistically significant correlations were found between OS and demographic or tumor-related characteristics. Conclusion. EGFR rs1468727 homozygote (genotype CC) and TNM stage showed statistically significant influence on OS in the follow-up period. This study highlights the potential significance of homozygote EGFR rs1468727 CC in assessing the prognosis and treatment outcomes of patients undergoing surgery for OSCC. |
| first_indexed | 2024-03-09T00:07:01Z |
| format | Article |
| id | doaj.art-3e5f2cf9fc004fb085ceba18a32b30f0 |
| institution | Directory Open Access Journal |
| issn | 0370-8179 2406-0895 |
| language | English |
| last_indexed | 2024-03-09T00:07:01Z |
| publishDate | 2023-01-01 |
| publisher | Serbian Medical Society |
| record_format | Article |
| series | Srpski Arhiv za Celokupno Lekarstvo |
| spelling | doaj.art-3e5f2cf9fc004fb085ceba18a32b30f02023-12-12T13:09:04ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792406-08952023-01-011519-1057257710.2298/SARH230306076B0370-81792300076BImpact of epidermal growth factor receptor gene RS1468727 polymorphism on survival of the patients with oral squamous cell carcinomaBačulov Katarina0Đan Mihajla1https://orcid.org/0000-0002-2427-0676Bajkin Branislav2https://orcid.org/0000-0003-2189-6769Mijatov Ivana3https://orcid.org/0000-0002-4771-4102Vučković Nada4https://orcid.org/0000-0002-8869-4806Mijatov Saša5Đan Igor6Barjaktarović Iva7https://orcid.org/0000-0003-2460-3458Stojčević-Maletić Jelena8Vučinić Nataša9https://orcid.org/0000-0001-6847-2862University of Novi Sad, Faculty of Medicine, University Clinical Center of Vojvodina, Center for Laboratory Medicine, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Science, Department of Biology and Ecology, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Clinic for Dentistry of Vojvodina, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, University Clinical Center of Vojvodina, Clinic for Maxillofacial and Oral Surgery, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, University Clinical Center of Vojvodina, Center for Pathology and Histology, SerbiaUniversity of Novi Sad, Faculty of Medicine, University Clinical Center of Vojvodina, Clinic for Maxillofacial and Oral Surgery, Novi Sad, SerbiaInstitute of Oncology of Vojvodina, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, University Clinical Center of Vojvodina, Center for Laboratory Medicine, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, University Clinical Center of Vojvodina, Center for Laboratory Medicine, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Department of Pharmacy, Novi Sad, SerbiaIntroduction/Objective. Genetic aberrations and environmental factors are known to play an important role in oral squamous cell carcinoma (OSCC). The aim of the study was to clarify the association of epidermal growth factor receptor (EGFR) gene polymorphism rs1468727 with overall survival (OS) in patients with OSCC. Methods. The study comprised a total of 61 patients diagnosed with OSCC. The follow-up period for each patient was three years from the date of surgery and during that period their genotypes for rs1468727 polymorphism of the EGFR gene were identified using real-time polymerase chain reaction. Binary logistic regression was used to investigate the influence of various variables on survival. Additionally, the χ2 test of independence and Man–Whitney U test were done to examine the interplay between two categorical variables and two independent samples. Results. Two variables demonstrated a statistically significant influence on OS: the TNM Classification of Malignant Tumors (TNM) stage and EGFR genotype. At the end of the follow-up period, 39 patients survived, with a noteworthy observation that more than half of the survivors had the EGFR rs1468727 CC genotype. The distribution of CC and CT genotypes was equal (χ2 = 0.397, df = 2, p = 0.820) among patients who deceased, indicating that no statistically significant correlations were found between OS and demographic or tumor-related characteristics. Conclusion. EGFR rs1468727 homozygote (genotype CC) and TNM stage showed statistically significant influence on OS in the follow-up period. This study highlights the potential significance of homozygote EGFR rs1468727 CC in assessing the prognosis and treatment outcomes of patients undergoing surgery for OSCC.https://doiserbia.nb.rs/img/doi/0370-8179/2023/0370-81792300076B.pdforal squamous cell carcinomaepidermal growth factor receptorpolymorphisms |
| spellingShingle | Bačulov Katarina Đan Mihajla Bajkin Branislav Mijatov Ivana Vučković Nada Mijatov Saša Đan Igor Barjaktarović Iva Stojčević-Maletić Jelena Vučinić Nataša Impact of epidermal growth factor receptor gene RS1468727 polymorphism on survival of the patients with oral squamous cell carcinoma Srpski Arhiv za Celokupno Lekarstvo oral squamous cell carcinoma epidermal growth factor receptor polymorphisms |
| title | Impact of epidermal growth factor receptor gene RS1468727 polymorphism on survival of the patients with oral squamous cell carcinoma |
| title_full | Impact of epidermal growth factor receptor gene RS1468727 polymorphism on survival of the patients with oral squamous cell carcinoma |
| title_fullStr | Impact of epidermal growth factor receptor gene RS1468727 polymorphism on survival of the patients with oral squamous cell carcinoma |
| title_full_unstemmed | Impact of epidermal growth factor receptor gene RS1468727 polymorphism on survival of the patients with oral squamous cell carcinoma |
| title_short | Impact of epidermal growth factor receptor gene RS1468727 polymorphism on survival of the patients with oral squamous cell carcinoma |
| title_sort | impact of epidermal growth factor receptor gene rs1468727 polymorphism on survival of the patients with oral squamous cell carcinoma |
| topic | oral squamous cell carcinoma epidermal growth factor receptor polymorphisms |
| url | https://doiserbia.nb.rs/img/doi/0370-8179/2023/0370-81792300076B.pdf |
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