BDNF Unveiled: Exploring Its Role in Major Depression Disorder Serotonergic Imbalance and Associated Stress Conditions
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays a significant role in the survival and development of neurons, being involved in several diseases such as Alzheimer’s disease and major depression disorder. The association between BDNF and major depressive disorder is the subject...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/8/2081 |
| _version_ | 1797583473275305984 |
|---|---|
| author | Ana Salomé Correia Armando Cardoso Nuno Vale |
| author_facet | Ana Salomé Correia Armando Cardoso Nuno Vale |
| author_sort | Ana Salomé Correia |
| collection | DOAJ |
| description | Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays a significant role in the survival and development of neurons, being involved in several diseases such as Alzheimer’s disease and major depression disorder. The association between BDNF and major depressive disorder is the subject of extensive research. Indeed, numerous studies indicate that decreased levels of BDNF are linked to an increased occurrence of depressive symptoms, neuronal loss, and cortical atrophy. Moreover, it has been observed that antidepressive therapy can help restore BDNF levels. In this review, we will focus on the role of BDNF in major depression disorder serotonergic imbalance and associated stress conditions, particularly hypothalamic–pituitary–adrenal (HPA) axis dysregulation and oxidative stress. All of these features are highly connected to BDNF signaling pathways in the context of this disease, and exploring this topic will aim to advance our understanding of the disorder, improve diagnostic and treatment approaches, and potentially identify new therapeutic targets to alleviate the heavy burden of depression on society. |
| first_indexed | 2024-03-10T23:39:23Z |
| format | Article |
| id | doaj.art-3e60af670513463b849237b14295e911 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T23:39:23Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-3e60af670513463b849237b14295e9112023-11-19T02:36:30ZengMDPI AGPharmaceutics1999-49232023-08-01158208110.3390/pharmaceutics15082081BDNF Unveiled: Exploring Its Role in Major Depression Disorder Serotonergic Imbalance and Associated Stress ConditionsAna Salomé Correia0Armando Cardoso1Nuno Vale2OncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, PortugalCINTESIS@RISE, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, PortugalOncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, PortugalBrain-derived neurotrophic factor (BDNF) is a neurotrophin that plays a significant role in the survival and development of neurons, being involved in several diseases such as Alzheimer’s disease and major depression disorder. The association between BDNF and major depressive disorder is the subject of extensive research. Indeed, numerous studies indicate that decreased levels of BDNF are linked to an increased occurrence of depressive symptoms, neuronal loss, and cortical atrophy. Moreover, it has been observed that antidepressive therapy can help restore BDNF levels. In this review, we will focus on the role of BDNF in major depression disorder serotonergic imbalance and associated stress conditions, particularly hypothalamic–pituitary–adrenal (HPA) axis dysregulation and oxidative stress. All of these features are highly connected to BDNF signaling pathways in the context of this disease, and exploring this topic will aim to advance our understanding of the disorder, improve diagnostic and treatment approaches, and potentially identify new therapeutic targets to alleviate the heavy burden of depression on society.https://www.mdpi.com/1999-4923/15/8/2081major depressive disorderbrain-derived neurotrophic factorserotoninhypothalamic–pituitary–adrenal axisoxidative stress |
| spellingShingle | Ana Salomé Correia Armando Cardoso Nuno Vale BDNF Unveiled: Exploring Its Role in Major Depression Disorder Serotonergic Imbalance and Associated Stress Conditions Pharmaceutics major depressive disorder brain-derived neurotrophic factor serotonin hypothalamic–pituitary–adrenal axis oxidative stress |
| title | BDNF Unveiled: Exploring Its Role in Major Depression Disorder Serotonergic Imbalance and Associated Stress Conditions |
| title_full | BDNF Unveiled: Exploring Its Role in Major Depression Disorder Serotonergic Imbalance and Associated Stress Conditions |
| title_fullStr | BDNF Unveiled: Exploring Its Role in Major Depression Disorder Serotonergic Imbalance and Associated Stress Conditions |
| title_full_unstemmed | BDNF Unveiled: Exploring Its Role in Major Depression Disorder Serotonergic Imbalance and Associated Stress Conditions |
| title_short | BDNF Unveiled: Exploring Its Role in Major Depression Disorder Serotonergic Imbalance and Associated Stress Conditions |
| title_sort | bdnf unveiled exploring its role in major depression disorder serotonergic imbalance and associated stress conditions |
| topic | major depressive disorder brain-derived neurotrophic factor serotonin hypothalamic–pituitary–adrenal axis oxidative stress |
| url | https://www.mdpi.com/1999-4923/15/8/2081 |
| work_keys_str_mv | AT anasalomecorreia bdnfunveiledexploringitsroleinmajordepressiondisorderserotonergicimbalanceandassociatedstressconditions AT armandocardoso bdnfunveiledexploringitsroleinmajordepressiondisorderserotonergicimbalanceandassociatedstressconditions AT nunovale bdnfunveiledexploringitsroleinmajordepressiondisorderserotonergicimbalanceandassociatedstressconditions |