Memory, processing of emotional stimuli, and volume of limbic structures in pediatric-onset multiple sclerosis
Objective: The limbic system is involved in memory and in processing of emotional stimuli. We measured volume of the hippocampus, amygdala, and thalamus, and assessed their relative contribution to episodic memory and emotion identification in POMS. Method: Sixty-five POMS participants (Mage = 18.3 ...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158221001972 |
| _version_ | 1818880914839568384 |
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| author | Tracy L. Fabri Ritobrato Datta Julia O'Mahony Emily Barlow-Krelina Elisea De Somma Giulia Longoni Raquel E. Gur Ruben C. Gur Micky Bacchus E. Ann Yeh Brenda L. Banwell Christine Till |
| author_facet | Tracy L. Fabri Ritobrato Datta Julia O'Mahony Emily Barlow-Krelina Elisea De Somma Giulia Longoni Raquel E. Gur Ruben C. Gur Micky Bacchus E. Ann Yeh Brenda L. Banwell Christine Till |
| author_sort | Tracy L. Fabri |
| collection | DOAJ |
| description | Objective: The limbic system is involved in memory and in processing of emotional stimuli. We measured volume of the hippocampus, amygdala, and thalamus, and assessed their relative contribution to episodic memory and emotion identification in POMS. Method: Sixty-five POMS participants (Mage = 18.3 ± 3.9 years; 48 female (73.8%)), average disease duration = 3.8 ± 3.8 years) and 76 age- and sex-matched controls (Mage = 18.1 ± 4.6 years; 49 female (64.5%)) completed the Penn Computerized Neurocognitive Battery (PCNB); 59 of 65 POMS participants and 69 out of 76 controls underwent 3 T MRI scanning. We derived age-adjusted Z-scores on accuracy and response time (RT) measures of episodic memory and emotion identification of the PCNB. Magnetic resonance imaging (MRI) volumetrics were normalized using the scaling factor computed by SIENAx. On PCNB tests that differed between groups, we used multiple linear regression to assess relationships between regional brain volumes and either episodic memory or emotion identification outcomes controlling for age, sex, accuracy/RT, and parental education. Results: POMS participants were slower and less accurate than controls on the episodic memory domain but did not differ from controls on emotion outcomes. At the subtest level, POMS participants showed reduced accuracy on Word Memory (p = .002) and slower performance on Face Memory (p = .04) subtests. POMS participants had smaller total and regional brain volumes of the hippocampus, amygdala, and thalamus (p values ≤ 0.01). Collapsing across groups, both hippocampal and thalamic volume were significant predictors of Word Memory accuracy; hippocampal volume (B = 0.24, SE = 0.10, p = .02) was more strongly associated with Word Memory performance than thalamic volume (B = 0.16, SE = 0.05, p = .003), though the estimate with was less precise. Conclusions: POMS participants showed reduced episodic memory performance compared to controls. Aspects of episodic memory performance were associated with hippocampal and thalamic volume. Emotion identification was intact, despite volume loss in the amygdala. |
| first_indexed | 2024-12-19T14:53:33Z |
| format | Article |
| id | doaj.art-3e614c99b70341bc9bee9653c009cf4c |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-19T14:53:33Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-3e614c99b70341bc9bee9653c009cf4c2022-12-21T20:16:47ZengElsevierNeuroImage: Clinical2213-15822021-01-0131102753Memory, processing of emotional stimuli, and volume of limbic structures in pediatric-onset multiple sclerosisTracy L. Fabri0Ritobrato Datta1Julia O'Mahony2Emily Barlow-Krelina3Elisea De Somma4Giulia Longoni5Raquel E. Gur6Ruben C. Gur7Micky Bacchus8E. Ann Yeh9Brenda L. Banwell10Christine Till11Department of Psychology, York University, CanadaDivision of Neurology, Children’s Hospital of Philadelphia, United StatesDepartments of Internal Medicine, University of Manitoba, Winnipeg, MB, CanadaDepartment of Psychology, York University, CanadaDepartment of Psychology, York University, CanadaDepartment of Paediatrics, Division of Neurology, The Hospital for Sick Children, University of Toronto, CanadaPenn-CHOP Lifespan Brain Institute, Departments of Psychiatry, Neurology, and Radiology, University of Pennsylvania School of Medicine, United StatesPenn-CHOP Lifespan Brain Institute, Departments of Psychiatry, Neurology, and Radiology, University of Pennsylvania School of Medicine, United StatesDivision of Neurology, Children’s Hospital of Philadelphia, United StatesDepartment of Paediatrics, Division of Neurology, The Hospital for Sick Children, University of Toronto, CanadaDivision of Neurology, Children’s Hospital of Philadelphia, United States; Perelman School of Medicine, University of Pennsylvania, United StatesDepartment of Psychology, York University, Canada; Department of Paediatrics, Division of Neurology, The Hospital for Sick Children, University of Toronto, Canada; Corresponding author at: 4700 Keele St, Toronto, ON M3J 1P3, Canada.Objective: The limbic system is involved in memory and in processing of emotional stimuli. We measured volume of the hippocampus, amygdala, and thalamus, and assessed their relative contribution to episodic memory and emotion identification in POMS. Method: Sixty-five POMS participants (Mage = 18.3 ± 3.9 years; 48 female (73.8%)), average disease duration = 3.8 ± 3.8 years) and 76 age- and sex-matched controls (Mage = 18.1 ± 4.6 years; 49 female (64.5%)) completed the Penn Computerized Neurocognitive Battery (PCNB); 59 of 65 POMS participants and 69 out of 76 controls underwent 3 T MRI scanning. We derived age-adjusted Z-scores on accuracy and response time (RT) measures of episodic memory and emotion identification of the PCNB. Magnetic resonance imaging (MRI) volumetrics were normalized using the scaling factor computed by SIENAx. On PCNB tests that differed between groups, we used multiple linear regression to assess relationships between regional brain volumes and either episodic memory or emotion identification outcomes controlling for age, sex, accuracy/RT, and parental education. Results: POMS participants were slower and less accurate than controls on the episodic memory domain but did not differ from controls on emotion outcomes. At the subtest level, POMS participants showed reduced accuracy on Word Memory (p = .002) and slower performance on Face Memory (p = .04) subtests. POMS participants had smaller total and regional brain volumes of the hippocampus, amygdala, and thalamus (p values ≤ 0.01). Collapsing across groups, both hippocampal and thalamic volume were significant predictors of Word Memory accuracy; hippocampal volume (B = 0.24, SE = 0.10, p = .02) was more strongly associated with Word Memory performance than thalamic volume (B = 0.16, SE = 0.05, p = .003), though the estimate with was less precise. Conclusions: POMS participants showed reduced episodic memory performance compared to controls. Aspects of episodic memory performance were associated with hippocampal and thalamic volume. Emotion identification was intact, despite volume loss in the amygdala.http://www.sciencedirect.com/science/article/pii/S2213158221001972Episodic memoryEmotion identificationNeurocognitive testingHippocampusAmygdalaThalamus |
| spellingShingle | Tracy L. Fabri Ritobrato Datta Julia O'Mahony Emily Barlow-Krelina Elisea De Somma Giulia Longoni Raquel E. Gur Ruben C. Gur Micky Bacchus E. Ann Yeh Brenda L. Banwell Christine Till Memory, processing of emotional stimuli, and volume of limbic structures in pediatric-onset multiple sclerosis NeuroImage: Clinical Episodic memory Emotion identification Neurocognitive testing Hippocampus Amygdala Thalamus |
| title | Memory, processing of emotional stimuli, and volume of limbic structures in pediatric-onset multiple sclerosis |
| title_full | Memory, processing of emotional stimuli, and volume of limbic structures in pediatric-onset multiple sclerosis |
| title_fullStr | Memory, processing of emotional stimuli, and volume of limbic structures in pediatric-onset multiple sclerosis |
| title_full_unstemmed | Memory, processing of emotional stimuli, and volume of limbic structures in pediatric-onset multiple sclerosis |
| title_short | Memory, processing of emotional stimuli, and volume of limbic structures in pediatric-onset multiple sclerosis |
| title_sort | memory processing of emotional stimuli and volume of limbic structures in pediatric onset multiple sclerosis |
| topic | Episodic memory Emotion identification Neurocognitive testing Hippocampus Amygdala Thalamus |
| url | http://www.sciencedirect.com/science/article/pii/S2213158221001972 |
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