Trends in Pneumococcal and Bacterial Meningitis in Brazil from 2007 to 2019
The pneumococcal conjugate vaccination (PCV) was introduced into the Brazilian Childhood National Immunization Program in 2010; however, universal pneumococcal vaccination for older adults has not been implemented yet. Our aim is to evaluate the trends in pneumococcal meningitis incidence and case f...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/8/1279 |
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| author | Cintia Irene Parellada Ariane de Jesus Lopes de Abreu Marina G. Birck Carolina Zampirolli Dias Thais das Neves Fraga Moreira Guilherme Silva Julian Paula de Mendonça Batista Juan Carlos Orengo Ana Luiza Bierrenbach |
| author_facet | Cintia Irene Parellada Ariane de Jesus Lopes de Abreu Marina G. Birck Carolina Zampirolli Dias Thais das Neves Fraga Moreira Guilherme Silva Julian Paula de Mendonça Batista Juan Carlos Orengo Ana Luiza Bierrenbach |
| author_sort | Cintia Irene Parellada |
| collection | DOAJ |
| description | The pneumococcal conjugate vaccination (PCV) was introduced into the Brazilian Childhood National Immunization Program in 2010; however, universal pneumococcal vaccination for older adults has not been implemented yet. Our aim is to evaluate the trends in pneumococcal meningitis incidence and case fatality rate (CFR) across all age groups from 2007 to 2019 using data from the National Surveillance System. The pre-PCV (2007–2009) and post-PCV (2011–2019) periods were compared; changes in incidence and CFR were assessed by joinpoint regression. Additional analyses of bacterial meningitis were performed to compare the patterns and trends. Over the 13-year period, 81,203 and 13,837 cases were classified as bacterial and pneumococcal meningitis, respectively. <i>S. pneumoniae</i> was the main etiological agent of bacterial meningitis in adults aged ≥50 years and the most lethal in all age groups. In the post-PCV period, a 56.5% reduction in the average incidence was seen in pneumococcal meningitis in the pediatric population. In contrast, there was an increasing trend among adults. The CFR for pneumococcal and bacterial meningitis remained stable in most age groups during the study period. These findings highlight the value of expanding pneumococcal vaccination policies, including vaccines that provide better indirect protection from children to adults and broadening vaccination to older adults. |
| first_indexed | 2024-03-10T23:31:28Z |
| format | Article |
| id | doaj.art-3e6230859f484d3189ef16a60ee79366 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T23:31:28Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-3e6230859f484d3189ef16a60ee793662023-11-19T03:16:50ZengMDPI AGVaccines2076-393X2023-07-01118127910.3390/vaccines11081279Trends in Pneumococcal and Bacterial Meningitis in Brazil from 2007 to 2019Cintia Irene Parellada0Ariane de Jesus Lopes de Abreu1Marina G. Birck2Carolina Zampirolli Dias3Thais das Neves Fraga Moreira4Guilherme Silva Julian5Paula de Mendonça Batista6Juan Carlos Orengo7Ana Luiza Bierrenbach8MSD Brazil, São Paulo 04583-110, BrazilIQVIA Brazil, São Paulo 04719-002, BrazilIQVIA Brazil, São Paulo 04719-002, BrazilIQVIA Brazil, São Paulo 04719-002, BrazilMSD Brazil, São Paulo 04583-110, BrazilIQVIA Brazil, São Paulo 04719-002, BrazilMSD Brazil, São Paulo 04583-110, BrazilMSD (IA) LLC, Guaynabo 00966, Puerto RicoInstituto de Ensino e Pesquisa, Hospital Sírio-Libanês, São Paulo 01308-050, BrazilThe pneumococcal conjugate vaccination (PCV) was introduced into the Brazilian Childhood National Immunization Program in 2010; however, universal pneumococcal vaccination for older adults has not been implemented yet. Our aim is to evaluate the trends in pneumococcal meningitis incidence and case fatality rate (CFR) across all age groups from 2007 to 2019 using data from the National Surveillance System. The pre-PCV (2007–2009) and post-PCV (2011–2019) periods were compared; changes in incidence and CFR were assessed by joinpoint regression. Additional analyses of bacterial meningitis were performed to compare the patterns and trends. Over the 13-year period, 81,203 and 13,837 cases were classified as bacterial and pneumococcal meningitis, respectively. <i>S. pneumoniae</i> was the main etiological agent of bacterial meningitis in adults aged ≥50 years and the most lethal in all age groups. In the post-PCV period, a 56.5% reduction in the average incidence was seen in pneumococcal meningitis in the pediatric population. In contrast, there was an increasing trend among adults. The CFR for pneumococcal and bacterial meningitis remained stable in most age groups during the study period. These findings highlight the value of expanding pneumococcal vaccination policies, including vaccines that provide better indirect protection from children to adults and broadening vaccination to older adults.https://www.mdpi.com/2076-393X/11/8/1279meningitisinvasive pneumococcal diseasevaccinationBrazilepidemiology |
| spellingShingle | Cintia Irene Parellada Ariane de Jesus Lopes de Abreu Marina G. Birck Carolina Zampirolli Dias Thais das Neves Fraga Moreira Guilherme Silva Julian Paula de Mendonça Batista Juan Carlos Orengo Ana Luiza Bierrenbach Trends in Pneumococcal and Bacterial Meningitis in Brazil from 2007 to 2019 Vaccines meningitis invasive pneumococcal disease vaccination Brazil epidemiology |
| title | Trends in Pneumococcal and Bacterial Meningitis in Brazil from 2007 to 2019 |
| title_full | Trends in Pneumococcal and Bacterial Meningitis in Brazil from 2007 to 2019 |
| title_fullStr | Trends in Pneumococcal and Bacterial Meningitis in Brazil from 2007 to 2019 |
| title_full_unstemmed | Trends in Pneumococcal and Bacterial Meningitis in Brazil from 2007 to 2019 |
| title_short | Trends in Pneumococcal and Bacterial Meningitis in Brazil from 2007 to 2019 |
| title_sort | trends in pneumococcal and bacterial meningitis in brazil from 2007 to 2019 |
| topic | meningitis invasive pneumococcal disease vaccination Brazil epidemiology |
| url | https://www.mdpi.com/2076-393X/11/8/1279 |
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