Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors
Distinct populations of Purkinje cells (PCs) with unique molecular and connectivity features are at the core of the modular organization of the cerebellum. Previously, we showed that firing activity of PCs differs between ZebrinII-positive and ZebrinII-negative cerebellar modules (Zhou et al., 2014;...
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| Format: | Article |
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eLife Sciences Publications Ltd
2021-05-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/63668 |
| _version_ | 1811202703499460608 |
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| author | Gerrit Cornelis Beekhof Catarina Osório Joshua J White Scott van Zoomeren Hannah van der Stok Bilian Xiong Ingo HMS Nettersheim Willem Ashwin Mak Marit Runge Francesca Romana Fiocchi Henk-Jan Boele Freek E Hoebeek Martijn Schonewille |
| author_facet | Gerrit Cornelis Beekhof Catarina Osório Joshua J White Scott van Zoomeren Hannah van der Stok Bilian Xiong Ingo HMS Nettersheim Willem Ashwin Mak Marit Runge Francesca Romana Fiocchi Henk-Jan Boele Freek E Hoebeek Martijn Schonewille |
| author_sort | Gerrit Cornelis Beekhof |
| collection | DOAJ |
| description | Distinct populations of Purkinje cells (PCs) with unique molecular and connectivity features are at the core of the modular organization of the cerebellum. Previously, we showed that firing activity of PCs differs between ZebrinII-positive and ZebrinII-negative cerebellar modules (Zhou et al., 2014; Wu et al., 2019). Here, we investigate the timing and extent of PC differentiation during development in mice. We found that several features of PCs, including activity levels, dendritic arborization, axonal shape and climbing fiber input, develop differentially between nodular and anterior PC populations. Although all PCs show a particularly rapid development in the second postnatal week, anterior PCs typically have a prolonged physiological and dendritic maturation. In line herewith, younger mice exhibit attenuated anterior-dependent eyeblink conditioning, but faster nodular-dependent compensatory eye movement adaptation. Our results indicate that specific cerebellar regions have unique developmental timelines which match with their related, specific forms of cerebellum-dependent behaviors. |
| first_indexed | 2024-04-12T02:42:50Z |
| format | Article |
| id | doaj.art-3e63f4188e7347519436936b6269724f |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:42:50Z |
| publishDate | 2021-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-3e63f4188e7347519436936b6269724f2022-12-22T03:51:16ZengeLife Sciences Publications LtdeLife2050-084X2021-05-011010.7554/eLife.63668Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviorsGerrit Cornelis Beekhof0https://orcid.org/0000-0002-3038-5023Catarina Osório1https://orcid.org/0000-0002-5228-0599Joshua J White2https://orcid.org/0000-0002-6218-623XScott van Zoomeren3Hannah van der Stok4https://orcid.org/0000-0002-4134-4075Bilian Xiong5Ingo HMS Nettersheim6https://orcid.org/0000-0001-5207-5328Willem Ashwin Mak7Marit Runge8Francesca Romana Fiocchi9Henk-Jan Boele10Freek E Hoebeek11Martijn Schonewille12https://orcid.org/0000-0002-2675-1393Department of Neuroscience, Erasmus MC, Rotterdam, NetherlandsDepartment of Neuroscience, Erasmus MC, Rotterdam, NetherlandsDepartment of Neuroscience, Erasmus MC, Rotterdam, NetherlandsDepartment of Neuroscience, Erasmus MC, Rotterdam, NetherlandsDepartment of Neuroscience, Erasmus MC, Rotterdam, NetherlandsDepartment of Neuroscience, Erasmus MC, Rotterdam, NetherlandsDepartment of Neuroscience, Erasmus MC, Rotterdam, NetherlandsDepartment of Neuroscience, Erasmus MC, Rotterdam, NetherlandsDepartment of Neuroscience, Erasmus MC, Rotterdam, NetherlandsDepartment of Neuroscience, Erasmus MC, Rotterdam, NetherlandsDepartment of Neuroscience, Erasmus MC, Rotterdam, Netherlands; Princeton Neuroscience Institute, Princeton, United StatesDepartment of Neuroscience, Erasmus MC, Rotterdam, Netherlands; Department for Developmental Origins of Disease, University Medical Center Utrecht Brain Center and Wilhelmina Children’s Hospital, Utrecht, NetherlandsDepartment of Neuroscience, Erasmus MC, Rotterdam, NetherlandsDistinct populations of Purkinje cells (PCs) with unique molecular and connectivity features are at the core of the modular organization of the cerebellum. Previously, we showed that firing activity of PCs differs between ZebrinII-positive and ZebrinII-negative cerebellar modules (Zhou et al., 2014; Wu et al., 2019). Here, we investigate the timing and extent of PC differentiation during development in mice. We found that several features of PCs, including activity levels, dendritic arborization, axonal shape and climbing fiber input, develop differentially between nodular and anterior PC populations. Although all PCs show a particularly rapid development in the second postnatal week, anterior PCs typically have a prolonged physiological and dendritic maturation. In line herewith, younger mice exhibit attenuated anterior-dependent eyeblink conditioning, but faster nodular-dependent compensatory eye movement adaptation. Our results indicate that specific cerebellar regions have unique developmental timelines which match with their related, specific forms of cerebellum-dependent behaviors.https://elifesciences.org/articles/63668cerebellumPurkinje cellelectrophysiologymorphologybehaviorZebrinII |
| spellingShingle | Gerrit Cornelis Beekhof Catarina Osório Joshua J White Scott van Zoomeren Hannah van der Stok Bilian Xiong Ingo HMS Nettersheim Willem Ashwin Mak Marit Runge Francesca Romana Fiocchi Henk-Jan Boele Freek E Hoebeek Martijn Schonewille Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors eLife cerebellum Purkinje cell electrophysiology morphology behavior ZebrinII |
| title | Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors |
| title_full | Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors |
| title_fullStr | Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors |
| title_full_unstemmed | Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors |
| title_short | Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors |
| title_sort | differential spatiotemporal development of purkinje cell populations and cerebellum dependent sensorimotor behaviors |
| topic | cerebellum Purkinje cell electrophysiology morphology behavior ZebrinII |
| url | https://elifesciences.org/articles/63668 |
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