PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses

PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses

A genetic variant in the gene PTPN22 (R620W, rs2476601) is strongly associated with increased risk for multiple autoimmune diseases and linked to altered TCR regulation and T cell activation. Here, we utilize Crispr/Cas9 gene editing with donor DNA repair templates in human cord blood-derived, naive...

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Bibliographic Details
Main Authors: Warren Anderson, Fariba Barahmand-pour-Whitman, Peter S Linsley, Karen Cerosaletti, Jane H Buckner, David J Rawlings
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
T cells
Crisper/ Cas9
transgenic TCR
cord blood
PTPN22
SNP
Online Access:https://elifesciences.org/articles/81577

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