Association of ACE1 I/D rs1799752 and ACE2 rs2285666 polymorphisms with the infection and severity of COVID‐19: A meta‐analysis
Abstract Background ACE1 I/D rs1799752 and ACE2 rs2285666 genetic polymorphisms could play a critical role in altering the clinical outcomes of SARS‐CoV‐2. The findings of previous studies remained inconclusive. This meta‐analysis was performed to evaluate the association and provide a more reliable...
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| Format: | Article |
| Language: | English |
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Wiley
2022-11-01
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| Series: | Molecular Genetics & Genomic Medicine |
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| Online Access: | https://doi.org/10.1002/mgg3.2063 |
| _version_ | 1798015431693303808 |
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| author | Md. Abdul Aziz Mohammad Safiqul Islam |
| author_facet | Md. Abdul Aziz Mohammad Safiqul Islam |
| author_sort | Md. Abdul Aziz |
| collection | DOAJ |
| description | Abstract Background ACE1 I/D rs1799752 and ACE2 rs2285666 genetic polymorphisms could play a critical role in altering the clinical outcomes of SARS‐CoV‐2. The findings of previous studies remained inconclusive. This meta‐analysis was performed to evaluate the association and provide a more reliable outcome. Methods This study was completed following the updated recommendations of PRISMA using RevMan 5.4.1 statistical software. Results A total of 11 studies with 950 severe cases and 1573 non‐severe cases with COVID‐19 infection were included. Pooled analysis showed that ACE1 I/D polymorphism was correlated with the severity of SARS‐CoV‐2 in the DD genotype and D allele for the fixed‐effects model (OR:1.27 and OR:1.17). Besides, codominant 3, recessive, and allele models were associated with the severity of the fixed‐effects model (OR:1.35, OR:1.37, and OR:1.20) in Caucasian ethnicity. ACE2 rs2285666 was linked with the severity in codominant 3 (OR:2.63, for both random‐ and fixed effects‐models), overdominant (OR:1.97, for random‐effects model and OR:1.97, for fixed effects‐model), and recessive model (OR:0.41 for fixed‐ and random‐effects model). Allele model of rs2285666 showed a significant association in the fixed‐effects model (OR:1.61). Conclusion Our present meta‐analysis suggests that ACE1 I/D rs1799752 and ACE2 rs2285666 variants may enhance the severity in SARS‐CoV‐2 infected patients. Future studies are warranted to verify our findings. |
| first_indexed | 2024-04-11T15:34:23Z |
| format | Article |
| id | doaj.art-3e67fa51e5ae4b989c31ccd4ce8ee56f |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-04-11T15:34:23Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-3e67fa51e5ae4b989c31ccd4ce8ee56f2022-12-22T04:16:03ZengWileyMolecular Genetics & Genomic Medicine2324-92692022-11-011011n/an/a10.1002/mgg3.2063Association of ACE1 I/D rs1799752 and ACE2 rs2285666 polymorphisms with the infection and severity of COVID‐19: A meta‐analysisMd. Abdul Aziz0Mohammad Safiqul Islam1Department of Pharmacy, Faculty of Pharmacy and Health Sciences State University of Bangladesh Dhaka BangladeshLaboratory of Pharmacogenomics and Molecular Biology, Department of Pharmacy Noakhali Science and Technology University Sonapur BangladeshAbstract Background ACE1 I/D rs1799752 and ACE2 rs2285666 genetic polymorphisms could play a critical role in altering the clinical outcomes of SARS‐CoV‐2. The findings of previous studies remained inconclusive. This meta‐analysis was performed to evaluate the association and provide a more reliable outcome. Methods This study was completed following the updated recommendations of PRISMA using RevMan 5.4.1 statistical software. Results A total of 11 studies with 950 severe cases and 1573 non‐severe cases with COVID‐19 infection were included. Pooled analysis showed that ACE1 I/D polymorphism was correlated with the severity of SARS‐CoV‐2 in the DD genotype and D allele for the fixed‐effects model (OR:1.27 and OR:1.17). Besides, codominant 3, recessive, and allele models were associated with the severity of the fixed‐effects model (OR:1.35, OR:1.37, and OR:1.20) in Caucasian ethnicity. ACE2 rs2285666 was linked with the severity in codominant 3 (OR:2.63, for both random‐ and fixed effects‐models), overdominant (OR:1.97, for random‐effects model and OR:1.97, for fixed effects‐model), and recessive model (OR:0.41 for fixed‐ and random‐effects model). Allele model of rs2285666 showed a significant association in the fixed‐effects model (OR:1.61). Conclusion Our present meta‐analysis suggests that ACE1 I/D rs1799752 and ACE2 rs2285666 variants may enhance the severity in SARS‐CoV‐2 infected patients. Future studies are warranted to verify our findings.https://doi.org/10.1002/mgg3.2063ACE1ACE2COVID‐19meta‐analysisSARS‐CoV‐2 |
| spellingShingle | Md. Abdul Aziz Mohammad Safiqul Islam Association of ACE1 I/D rs1799752 and ACE2 rs2285666 polymorphisms with the infection and severity of COVID‐19: A meta‐analysis Molecular Genetics & Genomic Medicine ACE1 ACE2 COVID‐19 meta‐analysis SARS‐CoV‐2 |
| title | Association of ACE1 I/D rs1799752 and ACE2 rs2285666 polymorphisms with the infection and severity of COVID‐19: A meta‐analysis |
| title_full | Association of ACE1 I/D rs1799752 and ACE2 rs2285666 polymorphisms with the infection and severity of COVID‐19: A meta‐analysis |
| title_fullStr | Association of ACE1 I/D rs1799752 and ACE2 rs2285666 polymorphisms with the infection and severity of COVID‐19: A meta‐analysis |
| title_full_unstemmed | Association of ACE1 I/D rs1799752 and ACE2 rs2285666 polymorphisms with the infection and severity of COVID‐19: A meta‐analysis |
| title_short | Association of ACE1 I/D rs1799752 and ACE2 rs2285666 polymorphisms with the infection and severity of COVID‐19: A meta‐analysis |
| title_sort | association of ace1 i d rs1799752 and ace2 rs2285666 polymorphisms with the infection and severity of covid 19 a meta analysis |
| topic | ACE1 ACE2 COVID‐19 meta‐analysis SARS‐CoV‐2 |
| url | https://doi.org/10.1002/mgg3.2063 |
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