Taylor’s focal cortical dysplasia revisited: History, original specimens and impact
50 years ago back in 1971, David C. Taylor and colleagues from England reported on a small series of surgical epilepsy cases proposing a new type of tissue lesion as a cause of difficult-to-treat focal epilepsy: a localized malformation of cerebral cortex. The lesion is now known as focal cortical d...
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| Format: | Article |
| Language: | English |
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University of Münster / Open Journals System
2021-04-01
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| Series: | Free Neuropathology |
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| Online Access: | https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/3324 |
| _version_ | 1818489140696580096 |
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| author | Burkhard S. Kasper |
| author_facet | Burkhard S. Kasper |
| author_sort | Burkhard S. Kasper |
| collection | DOAJ |
| description | 50 years ago back in 1971, David C. Taylor and colleagues from England reported on a small series of surgical epilepsy cases proposing a new type of tissue lesion as a cause of difficult-to-treat focal epilepsy: a localized malformation of cerebral cortex. The lesion is now known as focal cortical dysplasia (FCD) Type II or Taylor’s cortical dysplasia. FCD II is not rare, and today is a frequent finding in neurosurgical epilepsy specimens. Medical progress has been achieved in that the majority of FCD II is diagnosed non-invasively by magnetic resonance imaging today. Detailed studies on FCD revealed that the lesion belongs to a spectrum of mTOR-o-pathies, thereby confirming the authors´ initial hypothesis of a relationship to tuberous sclerosis. Here, selected original materials from Taylor´s series are presented as virtual slides, supplemented by original clinical records, in order to give a first-hand impression of this milestone finding in neuropathology of epilepsy. |
| first_indexed | 2024-12-10T16:59:50Z |
| format | Article |
| id | doaj.art-3e6824e683b64a999890ecfd0b3df489 |
| institution | Directory Open Access Journal |
| issn | 2699-4445 |
| language | English |
| last_indexed | 2024-12-10T16:59:50Z |
| publishDate | 2021-04-01 |
| publisher | University of Münster / Open Journals System |
| record_format | Article |
| series | Free Neuropathology |
| spelling | doaj.art-3e6824e683b64a999890ecfd0b3df4892022-12-22T01:40:35ZengUniversity of Münster / Open Journals SystemFree Neuropathology2699-44452021-04-01210.17879/freeneuropathology-2021-3324Taylor’s focal cortical dysplasia revisited: History, original specimens and impactBurkhard S. Kasper0Epilepsy Center, Department of Neurology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany50 years ago back in 1971, David C. Taylor and colleagues from England reported on a small series of surgical epilepsy cases proposing a new type of tissue lesion as a cause of difficult-to-treat focal epilepsy: a localized malformation of cerebral cortex. The lesion is now known as focal cortical dysplasia (FCD) Type II or Taylor’s cortical dysplasia. FCD II is not rare, and today is a frequent finding in neurosurgical epilepsy specimens. Medical progress has been achieved in that the majority of FCD II is diagnosed non-invasively by magnetic resonance imaging today. Detailed studies on FCD revealed that the lesion belongs to a spectrum of mTOR-o-pathies, thereby confirming the authors´ initial hypothesis of a relationship to tuberous sclerosis. Here, selected original materials from Taylor´s series are presented as virtual slides, supplemented by original clinical records, in order to give a first-hand impression of this milestone finding in neuropathology of epilepsy.https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/3324DysplasiaEpilepsyHistoryTaylorFCD |
| spellingShingle | Burkhard S. Kasper Taylor’s focal cortical dysplasia revisited: History, original specimens and impact Free Neuropathology Dysplasia Epilepsy History Taylor FCD |
| title | Taylor’s focal cortical dysplasia revisited: History, original specimens and impact |
| title_full | Taylor’s focal cortical dysplasia revisited: History, original specimens and impact |
| title_fullStr | Taylor’s focal cortical dysplasia revisited: History, original specimens and impact |
| title_full_unstemmed | Taylor’s focal cortical dysplasia revisited: History, original specimens and impact |
| title_short | Taylor’s focal cortical dysplasia revisited: History, original specimens and impact |
| title_sort | taylor s focal cortical dysplasia revisited history original specimens and impact |
| topic | Dysplasia Epilepsy History Taylor FCD |
| url | https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/3324 |
| work_keys_str_mv | AT burkhardskasper taylorsfocalcorticaldysplasiarevisitedhistoryoriginalspecimensandimpact |