Antimicrobial Selection for the Treatment of Clinical Mastitis and the Efficacy of Penicillin Treatment Protocols in Large Estonian Dairy Herds
Clinical mastitis (CM) is the most common microbial disease treated in dairy cows. We analyzed the antimicrobial usage in cows with CM (<i>n</i> = 11,420) in large dairy herds (<i>n</i> = 43) in Estonia. CM treatment data were collected during a 12-month study period. The ant...
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MDPI AG
2021-12-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/1/44 |
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| author | Anri Timonen Marju Sammul Suvi Taponen Tanel Kaart Kerli Mõtus Piret Kalmus |
| author_facet | Anri Timonen Marju Sammul Suvi Taponen Tanel Kaart Kerli Mõtus Piret Kalmus |
| author_sort | Anri Timonen |
| collection | DOAJ |
| description | Clinical mastitis (CM) is the most common microbial disease treated in dairy cows. We analyzed the antimicrobial usage in cows with CM (<i>n</i> = 11,420) in large dairy herds (<i>n</i> = 43) in Estonia. CM treatment data were collected during a 12-month study period. The antimicrobial usage was observed during the 21 days from the initiation of treatment, and the incidence of antimicrobial-treated CM was calculated for each study herd. The effect of intramammary (IMM), systemic, and combined (systemic and IMM) penicillin treatment of CM on the post-treatment somatic cell count (SCC) was analyzed using the treatment records of 2222 cows from 24 herds with a mixed multivariable linear regression model. The median incidence of antimicrobial-treated CM was 35.8 per 100 cow-years. Procaine benzylpenicillin and marbofloxacin were used in 6103 (35.5%, 95% CI 34.8–36.2) and 2839 (16.5%, 95% CI 16.0–17.1) CM treatments, respectively. Post-treatment SCC was higher after IMM penicillin therapy compared to systemic or combination therapy. Treatment of CM usually included first-choice antimicrobials, but different antimicrobial combinations were also widely used. The effect of procaine benzylpenicillin to post-treatment SCC was dependent on the administration route, cow parity, and days in milk. Further studies should evaluate the factors affecting veterinarians’ choice of antimicrobial used in the treatment of CM. |
| first_indexed | 2024-03-10T03:02:33Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T03:02:33Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-3e6903d3d077443caf2a6b8896461f542023-11-23T12:43:41ZengMDPI AGAntibiotics2079-63822021-12-011114410.3390/antibiotics11010044Antimicrobial Selection for the Treatment of Clinical Mastitis and the Efficacy of Penicillin Treatment Protocols in Large Estonian Dairy HerdsAnri Timonen0Marju Sammul1Suvi Taponen2Tanel Kaart3Kerli Mõtus4Piret Kalmus5Faculty of Veterinary Medicine, University of Helsinki, Yliopistonkatu 3, 00014 Helsinki, FinlandInstitute of Veterinary Medicine and Animal Science, Estonian University of Life Sciences, Kreutzwaldi 62, 51006 Tartu, EstoniaFaculty of Veterinary Medicine, University of Helsinki, Yliopistonkatu 3, 00014 Helsinki, FinlandInstitute of Veterinary Medicine and Animal Science, Estonian University of Life Sciences, Kreutzwaldi 62, 51006 Tartu, EstoniaInstitute of Veterinary Medicine and Animal Science, Estonian University of Life Sciences, Kreutzwaldi 62, 51006 Tartu, EstoniaInstitute of Veterinary Medicine and Animal Science, Estonian University of Life Sciences, Kreutzwaldi 62, 51006 Tartu, EstoniaClinical mastitis (CM) is the most common microbial disease treated in dairy cows. We analyzed the antimicrobial usage in cows with CM (<i>n</i> = 11,420) in large dairy herds (<i>n</i> = 43) in Estonia. CM treatment data were collected during a 12-month study period. The antimicrobial usage was observed during the 21 days from the initiation of treatment, and the incidence of antimicrobial-treated CM was calculated for each study herd. The effect of intramammary (IMM), systemic, and combined (systemic and IMM) penicillin treatment of CM on the post-treatment somatic cell count (SCC) was analyzed using the treatment records of 2222 cows from 24 herds with a mixed multivariable linear regression model. The median incidence of antimicrobial-treated CM was 35.8 per 100 cow-years. Procaine benzylpenicillin and marbofloxacin were used in 6103 (35.5%, 95% CI 34.8–36.2) and 2839 (16.5%, 95% CI 16.0–17.1) CM treatments, respectively. Post-treatment SCC was higher after IMM penicillin therapy compared to systemic or combination therapy. Treatment of CM usually included first-choice antimicrobials, but different antimicrobial combinations were also widely used. The effect of procaine benzylpenicillin to post-treatment SCC was dependent on the administration route, cow parity, and days in milk. Further studies should evaluate the factors affecting veterinarians’ choice of antimicrobial used in the treatment of CM.https://www.mdpi.com/2079-6382/11/1/44dairy cowclinical mastitisantimicrobial |
| spellingShingle | Anri Timonen Marju Sammul Suvi Taponen Tanel Kaart Kerli Mõtus Piret Kalmus Antimicrobial Selection for the Treatment of Clinical Mastitis and the Efficacy of Penicillin Treatment Protocols in Large Estonian Dairy Herds Antibiotics dairy cow clinical mastitis antimicrobial |
| title | Antimicrobial Selection for the Treatment of Clinical Mastitis and the Efficacy of Penicillin Treatment Protocols in Large Estonian Dairy Herds |
| title_full | Antimicrobial Selection for the Treatment of Clinical Mastitis and the Efficacy of Penicillin Treatment Protocols in Large Estonian Dairy Herds |
| title_fullStr | Antimicrobial Selection for the Treatment of Clinical Mastitis and the Efficacy of Penicillin Treatment Protocols in Large Estonian Dairy Herds |
| title_full_unstemmed | Antimicrobial Selection for the Treatment of Clinical Mastitis and the Efficacy of Penicillin Treatment Protocols in Large Estonian Dairy Herds |
| title_short | Antimicrobial Selection for the Treatment of Clinical Mastitis and the Efficacy of Penicillin Treatment Protocols in Large Estonian Dairy Herds |
| title_sort | antimicrobial selection for the treatment of clinical mastitis and the efficacy of penicillin treatment protocols in large estonian dairy herds |
| topic | dairy cow clinical mastitis antimicrobial |
| url | https://www.mdpi.com/2079-6382/11/1/44 |
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