Comparison of the effect of penicillins versus erythromycin in preventing neonatal group B streptococcus infection in active carriers following preterm prelabor rupture of membranes
Objective: To compare the incidence of neonatal group B streptococcus (GBS) infection in active GBS carriers with preterm prelabor rupture of membranes (PPROMs) after penicillins and erythromycin prophylaxis. Materials and methods: Patients diagnosed to have PPROM between 2004 and 2009 inclusive wer...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-06-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455914000734 |
| _version_ | 1819294074372358144 |
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| author | Sik Wing Yeung Daljit Singh Sahota Tak Yeung Leung |
| author_facet | Sik Wing Yeung Daljit Singh Sahota Tak Yeung Leung |
| author_sort | Sik Wing Yeung |
| collection | DOAJ |
| description | Objective: To compare the incidence of neonatal group B streptococcus (GBS) infection in active GBS carriers with preterm prelabor rupture of membranes (PPROMs) after penicillins and erythromycin prophylaxis.
Materials and methods: Patients diagnosed to have PPROM between 2004 and 2009 inclusive were treated using erythromycin (erythromycin group), ampicillin, amoxicillin or co-amoxiclav (penicillin group), or no antibiotics (control group) according to department protocols depending on their gestation and their GBS status at the time of presentation. Patients receiving both erythromycin and penicillins were included in the penicillin group. The incidence of neonatal GBS infection was compared between groups categorized according to the antibiotic regime received.
Results: A total of 680 women were diagnosed to have PPROM of which 85 (12.5%) were active GBS carriers. GBS isolates were 100% sensitive to penicillins but only 35% were sensitive to erythromycin. There were 16, 22, and 47 patients in the penicillin, erythromycin, and control groups, respectively. The incidence of neonatal GBS infection in the three groups was 0%, 36%, and 13%, respectively, and was statistically significant (p = 0.023).
Conclusion: Penicillins are more effective than erythromycin in preventing neonatal GBS infection in women with PPROM who were active GBS carriers. Because most women do not know their GBS status at the time of PPROM and it is practically difficult to identify the active carriers before delivery, ampicillin/amoxicillin should be used as a prophylactic antibiotic for active GBS carriers and women with unknown GBS carriage status to prevent neonatal GBS infection following PPROM. |
| first_indexed | 2024-12-24T04:20:32Z |
| format | Article |
| id | doaj.art-3e698b9ded01472bb0d736d08873f1cf |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-24T04:20:32Z |
| publishDate | 2014-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-3e698b9ded01472bb0d736d08873f1cf2022-12-21T17:15:49ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592014-06-0153221021410.1016/j.tjog.2014.04.016Comparison of the effect of penicillins versus erythromycin in preventing neonatal group B streptococcus infection in active carriers following preterm prelabor rupture of membranesSik Wing YeungDaljit Singh SahotaTak Yeung LeungObjective: To compare the incidence of neonatal group B streptococcus (GBS) infection in active GBS carriers with preterm prelabor rupture of membranes (PPROMs) after penicillins and erythromycin prophylaxis. Materials and methods: Patients diagnosed to have PPROM between 2004 and 2009 inclusive were treated using erythromycin (erythromycin group), ampicillin, amoxicillin or co-amoxiclav (penicillin group), or no antibiotics (control group) according to department protocols depending on their gestation and their GBS status at the time of presentation. Patients receiving both erythromycin and penicillins were included in the penicillin group. The incidence of neonatal GBS infection was compared between groups categorized according to the antibiotic regime received. Results: A total of 680 women were diagnosed to have PPROM of which 85 (12.5%) were active GBS carriers. GBS isolates were 100% sensitive to penicillins but only 35% were sensitive to erythromycin. There were 16, 22, and 47 patients in the penicillin, erythromycin, and control groups, respectively. The incidence of neonatal GBS infection in the three groups was 0%, 36%, and 13%, respectively, and was statistically significant (p = 0.023). Conclusion: Penicillins are more effective than erythromycin in preventing neonatal GBS infection in women with PPROM who were active GBS carriers. Because most women do not know their GBS status at the time of PPROM and it is practically difficult to identify the active carriers before delivery, ampicillin/amoxicillin should be used as a prophylactic antibiotic for active GBS carriers and women with unknown GBS carriage status to prevent neonatal GBS infection following PPROM.http://www.sciencedirect.com/science/article/pii/S1028455914000734erythromycinpenicillinspremature rupture of membranesStreptococcus agalactiae |
| spellingShingle | Sik Wing Yeung Daljit Singh Sahota Tak Yeung Leung Comparison of the effect of penicillins versus erythromycin in preventing neonatal group B streptococcus infection in active carriers following preterm prelabor rupture of membranes Taiwanese Journal of Obstetrics & Gynecology erythromycin penicillins premature rupture of membranes Streptococcus agalactiae |
| title | Comparison of the effect of penicillins versus erythromycin in preventing neonatal group B streptococcus infection in active carriers following preterm prelabor rupture of membranes |
| title_full | Comparison of the effect of penicillins versus erythromycin in preventing neonatal group B streptococcus infection in active carriers following preterm prelabor rupture of membranes |
| title_fullStr | Comparison of the effect of penicillins versus erythromycin in preventing neonatal group B streptococcus infection in active carriers following preterm prelabor rupture of membranes |
| title_full_unstemmed | Comparison of the effect of penicillins versus erythromycin in preventing neonatal group B streptococcus infection in active carriers following preterm prelabor rupture of membranes |
| title_short | Comparison of the effect of penicillins versus erythromycin in preventing neonatal group B streptococcus infection in active carriers following preterm prelabor rupture of membranes |
| title_sort | comparison of the effect of penicillins versus erythromycin in preventing neonatal group b streptococcus infection in active carriers following preterm prelabor rupture of membranes |
| topic | erythromycin penicillins premature rupture of membranes Streptococcus agalactiae |
| url | http://www.sciencedirect.com/science/article/pii/S1028455914000734 |
| work_keys_str_mv | AT sikwingyeung comparisonoftheeffectofpenicillinsversuserythromycininpreventingneonatalgroupbstreptococcusinfectioninactivecarriersfollowingpretermprelaborruptureofmembranes AT daljitsinghsahota comparisonoftheeffectofpenicillinsversuserythromycininpreventingneonatalgroupbstreptococcusinfectioninactivecarriersfollowingpretermprelaborruptureofmembranes AT takyeungleung comparisonoftheeffectofpenicillinsversuserythromycininpreventingneonatalgroupbstreptococcusinfectioninactivecarriersfollowingpretermprelaborruptureofmembranes |