Phosphate Dysregulation and Metabolic Syndrome
Phosphorus is one of the most abundant minerals in the human body. It is essential for almost all biochemical activities through ATP formation, intracellular signal transduction, cell membrane formation, bone mineralization, DNA and RNA synthesis, and inflammation modulation through various inflamma...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/21/4477 |
| _version_ | 1797466948474241024 |
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| author | Nikolay Mironov Mainul Haque Azeddine Atfi Mohammed S. Razzaque |
| author_facet | Nikolay Mironov Mainul Haque Azeddine Atfi Mohammed S. Razzaque |
| author_sort | Nikolay Mironov |
| collection | DOAJ |
| description | Phosphorus is one of the most abundant minerals in the human body. It is essential for almost all biochemical activities through ATP formation, intracellular signal transduction, cell membrane formation, bone mineralization, DNA and RNA synthesis, and inflammation modulation through various inflammatory cytokines. Phosphorus levels must be optimally regulated, as any deviations may lead to substantial derangements in glucose homeostasis. Clinical studies have reported that hyperphosphatemia can increase an individual’s risk of developing metabolic syndrome. High phosphate burden has been shown to impair glucose metabolism by impairing pancreatic insulin secretion and increasing the risk of cardiometabolic disorders. Phosphate toxicity deserves more attention as metabolic syndrome is being seen more frequently worldwide and should be investigated further to determine the underlying mechanism of how phosphate burden may increase the cardiometabolic risk in the general population. |
| first_indexed | 2024-03-09T18:46:50Z |
| format | Article |
| id | doaj.art-3e69c4bb3ec743dd94d6101b2555a0d4 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T18:46:50Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3e69c4bb3ec743dd94d6101b2555a0d42023-11-24T06:12:06ZengMDPI AGNutrients2072-66432022-10-011421447710.3390/nu14214477Phosphate Dysregulation and Metabolic SyndromeNikolay Mironov0Mainul Haque1Azeddine Atfi2Mohammed S. Razzaque3Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA 16509, USAUnit of Pharmacology, Faculty of Medicine and Defense Health, National Defense University of Malaysia, Kuala Lumpur 57000, MalaysiaDepartment of Pathology, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA 16509, USAPhosphorus is one of the most abundant minerals in the human body. It is essential for almost all biochemical activities through ATP formation, intracellular signal transduction, cell membrane formation, bone mineralization, DNA and RNA synthesis, and inflammation modulation through various inflammatory cytokines. Phosphorus levels must be optimally regulated, as any deviations may lead to substantial derangements in glucose homeostasis. Clinical studies have reported that hyperphosphatemia can increase an individual’s risk of developing metabolic syndrome. High phosphate burden has been shown to impair glucose metabolism by impairing pancreatic insulin secretion and increasing the risk of cardiometabolic disorders. Phosphate toxicity deserves more attention as metabolic syndrome is being seen more frequently worldwide and should be investigated further to determine the underlying mechanism of how phosphate burden may increase the cardiometabolic risk in the general population.https://www.mdpi.com/2072-6643/14/21/4477phosphate burdenobesityhypertensiondiabetesinsulin |
| spellingShingle | Nikolay Mironov Mainul Haque Azeddine Atfi Mohammed S. Razzaque Phosphate Dysregulation and Metabolic Syndrome Nutrients phosphate burden obesity hypertension diabetes insulin |
| title | Phosphate Dysregulation and Metabolic Syndrome |
| title_full | Phosphate Dysregulation and Metabolic Syndrome |
| title_fullStr | Phosphate Dysregulation and Metabolic Syndrome |
| title_full_unstemmed | Phosphate Dysregulation and Metabolic Syndrome |
| title_short | Phosphate Dysregulation and Metabolic Syndrome |
| title_sort | phosphate dysregulation and metabolic syndrome |
| topic | phosphate burden obesity hypertension diabetes insulin |
| url | https://www.mdpi.com/2072-6643/14/21/4477 |
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