Differentially expressed microRNAs in aneuploid preimplantation blastocysts: a systematic review
IntroductionMicroRNAs are small noncoding genes with gene expression regulatory function. Their emergence as potential diagnostic biomarker for many diseases has gained a specific interest among researchers. Observations of changes in miRNA levels correlating with aneuploidy in early embryos raise t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Reproductive Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frph.2024.1370341/full |
| _version_ | 1797263045980848128 |
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| author | Arwa Almutlaq Arwa Almutlaq Xavier Viñals Gonzalez Sioban SenGupta |
| author_facet | Arwa Almutlaq Arwa Almutlaq Xavier Viñals Gonzalez Sioban SenGupta |
| author_sort | Arwa Almutlaq |
| collection | DOAJ |
| description | IntroductionMicroRNAs are small noncoding genes with gene expression regulatory function. Their emergence as potential diagnostic biomarker for many diseases has gained a specific interest among researchers. Observations of changes in miRNA levels correlating with aneuploidy in early embryos raise the prospective of employing miRNA as biomarkers to assess the embryo quality.MethodTo identify and gather the miRNAs with potential link to chromosomal abnormalities in embryos from previous research, we conducted a systematic search using four databases, including Embase, Medline, Web of Science, and Cochrane databases in accordance with PRISMA guidelines.ResultsOut of 200 identified records, only seven met the inclusion criteria. Seven miRNAs: miR-19b, miR-517c, miR-518e, miR-522, miR-92a, and miR-106a exhibited persistent downregulation in aneuploid blastocysts in the included studies. These miRNAs are members of important miRNA clusters, associated with abnormal expression in studies on reproductive failure. Pathway analysis revealed their involvement in regulating gene transcription, as well as cell cycle progression and apoptosis.DiscussionThe changes detected in the miRNA expression in aneuploid embryos across different studies support the aneuploidy and miRNA relationship and prospect miRNA as a valuable tool for the assessment of embryo quality. Collectively, these observations highlight the role of miRNAs in embryonic development, and their involvement in genetic abnormalities that occur in embryos, such as aneuploidy, indicating their potential implementation to improve the embryo selection and reproductive outcomes. |
| first_indexed | 2024-04-25T00:06:46Z |
| format | Article |
| id | doaj.art-3e6a69e33e154413963106c2125671c6 |
| institution | Directory Open Access Journal |
| issn | 2673-3153 |
| language | English |
| last_indexed | 2024-04-25T00:06:46Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Reproductive Health |
| spelling | doaj.art-3e6a69e33e154413963106c2125671c62024-03-14T05:08:46ZengFrontiers Media S.A.Frontiers in Reproductive Health2673-31532024-03-01610.3389/frph.2024.13703411370341Differentially expressed microRNAs in aneuploid preimplantation blastocysts: a systematic reviewArwa Almutlaq0Arwa Almutlaq1Xavier Viñals Gonzalez2Sioban SenGupta3Reproductive Health, Institute for Women’s Health, University College London (UCL), London, United KingdomClinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi ArabiaReproductive Health, Institute for Women’s Health, University College London (UCL), London, United KingdomReproductive Health, Institute for Women’s Health, University College London (UCL), London, United KingdomIntroductionMicroRNAs are small noncoding genes with gene expression regulatory function. Their emergence as potential diagnostic biomarker for many diseases has gained a specific interest among researchers. Observations of changes in miRNA levels correlating with aneuploidy in early embryos raise the prospective of employing miRNA as biomarkers to assess the embryo quality.MethodTo identify and gather the miRNAs with potential link to chromosomal abnormalities in embryos from previous research, we conducted a systematic search using four databases, including Embase, Medline, Web of Science, and Cochrane databases in accordance with PRISMA guidelines.ResultsOut of 200 identified records, only seven met the inclusion criteria. Seven miRNAs: miR-19b, miR-517c, miR-518e, miR-522, miR-92a, and miR-106a exhibited persistent downregulation in aneuploid blastocysts in the included studies. These miRNAs are members of important miRNA clusters, associated with abnormal expression in studies on reproductive failure. Pathway analysis revealed their involvement in regulating gene transcription, as well as cell cycle progression and apoptosis.DiscussionThe changes detected in the miRNA expression in aneuploid embryos across different studies support the aneuploidy and miRNA relationship and prospect miRNA as a valuable tool for the assessment of embryo quality. Collectively, these observations highlight the role of miRNAs in embryonic development, and their involvement in genetic abnormalities that occur in embryos, such as aneuploidy, indicating their potential implementation to improve the embryo selection and reproductive outcomes.https://www.frontiersin.org/articles/10.3389/frph.2024.1370341/fullmicroRNA (miRNA)aneuploidyblastocystembryo qualitybiomarker |
| spellingShingle | Arwa Almutlaq Arwa Almutlaq Xavier Viñals Gonzalez Sioban SenGupta Differentially expressed microRNAs in aneuploid preimplantation blastocysts: a systematic review Frontiers in Reproductive Health microRNA (miRNA) aneuploidy blastocyst embryo quality biomarker |
| title | Differentially expressed microRNAs in aneuploid preimplantation blastocysts: a systematic review |
| title_full | Differentially expressed microRNAs in aneuploid preimplantation blastocysts: a systematic review |
| title_fullStr | Differentially expressed microRNAs in aneuploid preimplantation blastocysts: a systematic review |
| title_full_unstemmed | Differentially expressed microRNAs in aneuploid preimplantation blastocysts: a systematic review |
| title_short | Differentially expressed microRNAs in aneuploid preimplantation blastocysts: a systematic review |
| title_sort | differentially expressed micrornas in aneuploid preimplantation blastocysts a systematic review |
| topic | microRNA (miRNA) aneuploidy blastocyst embryo quality biomarker |
| url | https://www.frontiersin.org/articles/10.3389/frph.2024.1370341/full |
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