Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy
Peptidyl-prolyl <i>cis-trans</i> isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in cancers and plays an impor...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/4/359 |
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| author | Hsiang-Hao Chuang Yen-Yi Zhen Yu-Chen Tsai Cheng-Hao Chuang Ming-Shyan Huang Michael Hsiao Chih-Jen Yang |
| author_facet | Hsiang-Hao Chuang Yen-Yi Zhen Yu-Chen Tsai Cheng-Hao Chuang Ming-Shyan Huang Michael Hsiao Chih-Jen Yang |
| author_sort | Hsiang-Hao Chuang |
| collection | DOAJ |
| description | Peptidyl-prolyl <i>cis-trans</i> isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in cancers and plays an important role in tumorigenesis. Mounting evidence has revealed that targeting Pin1 is a potential therapeutic approach for various cancers by inhibiting cell proliferation, reducing metastasis, and maintaining genome stability. In this review, we summarize the underlying mechanisms of Pin1-mediated upregulation of oncogenes and downregulation of tumor suppressors in cancer development. Furthermore, we also discuss the multiple roles of Pin1 in cancer hallmarks and examine Pin1 as a desirable pharmaceutical target for cancer therapy. We also summarize the recent progress of Pin1-targeted small-molecule compounds for anticancer activity. |
| first_indexed | 2024-03-10T12:45:22Z |
| format | Article |
| id | doaj.art-3e6de68364774303935ec9f5d90d6ff4 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T12:45:22Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-3e6de68364774303935ec9f5d90d6ff42023-11-21T13:32:10ZengMDPI AGBiomedicines2227-90592021-03-019435910.3390/biomedicines9040359Targeting Pin1 for Modulation of Cell Motility and Cancer TherapyHsiang-Hao Chuang0Yen-Yi Zhen1Yu-Chen Tsai2Cheng-Hao Chuang3Ming-Shyan Huang4Michael Hsiao5Chih-Jen Yang6Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDepartment of Internal Medicine, E-Da Cancer Hospital, School of Medicine, I-Shou University, Kaohsiung 82445, TaiwanGenomics Research Center, Academia Sinica, Taipei 11529, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, TaiwanPeptidyl-prolyl <i>cis-trans</i> isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in cancers and plays an important role in tumorigenesis. Mounting evidence has revealed that targeting Pin1 is a potential therapeutic approach for various cancers by inhibiting cell proliferation, reducing metastasis, and maintaining genome stability. In this review, we summarize the underlying mechanisms of Pin1-mediated upregulation of oncogenes and downregulation of tumor suppressors in cancer development. Furthermore, we also discuss the multiple roles of Pin1 in cancer hallmarks and examine Pin1 as a desirable pharmaceutical target for cancer therapy. We also summarize the recent progress of Pin1-targeted small-molecule compounds for anticancer activity.https://www.mdpi.com/2227-9059/9/4/359Pin1<i>cis</i>-<i>trans</i> isomerizationtumorigenesiscell motilitymetastasiscancer therapeutics |
| spellingShingle | Hsiang-Hao Chuang Yen-Yi Zhen Yu-Chen Tsai Cheng-Hao Chuang Ming-Shyan Huang Michael Hsiao Chih-Jen Yang Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy Biomedicines Pin1 <i>cis</i>-<i>trans</i> isomerization tumorigenesis cell motility metastasis cancer therapeutics |
| title | Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy |
| title_full | Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy |
| title_fullStr | Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy |
| title_full_unstemmed | Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy |
| title_short | Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy |
| title_sort | targeting pin1 for modulation of cell motility and cancer therapy |
| topic | Pin1 <i>cis</i>-<i>trans</i> isomerization tumorigenesis cell motility metastasis cancer therapeutics |
| url | https://www.mdpi.com/2227-9059/9/4/359 |
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