Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy

Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy

Peptidyl-prolyl <i>cis-trans</i> isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in cancers and plays an impor...

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Bibliographic Details
Main Authors: Hsiang-Hao Chuang, Yen-Yi Zhen, Yu-Chen Tsai, Cheng-Hao Chuang, Ming-Shyan Huang, Michael Hsiao, Chih-Jen Yang
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Biomedicines
Subjects:
Pin1
<i>cis</i>-<i>trans</i> isomerization
tumorigenesis
cell motility
metastasis
cancer therapeutics
Online Access:https://www.mdpi.com/2227-9059/9/4/359

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