Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Inflammation and Fibrosis; Potential Implications for Idiopathic Pulmonary Fibrosis

Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Inflammation and Fibrosis; Potential Implications for Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a disease characterized by irreversible lung scarring. The pathophysiology is not fully understood, but the working hypothesis postulates that a combination of epithelial injury and myofibroblast differentiation drives progressive pulmonary fibrosis. We previou...

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Bibliographic Details
Main Authors: David J. Nagel, Ashley R. Rackow, Wei-Yao Ku, Tyler J. Bell, Patricia J. Sime, Robert Matthew Kottmann
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
pulmonary fibrosis
OGR1 (GPR68)
fibroblast
epithelial cell
GPCR
TGFβ signaling
Online Access:https://www.mdpi.com/2073-4409/11/16/2540

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