AMPKα2 promotes tumor immune escape by inducing CD8+ T-cell exhaustion and CD4+ Treg cell formation in liver hepatocellular carcinoma

AMPKα2 promotes tumor immune escape by inducing CD8+ T-cell exhaustion and CD4+ Treg cell formation in liver hepatocellular carcinoma

Abstract Background Adenosine monophosphate-activated protein kinase (AMPK) is associated with the development of liver hepatocellular carcinoma (LIHC). AMPKα2, an α2 subunit of AMPK, is encoded by PRKAA2, and functions as the catalytic core of AMPK. However, the role of AMPKα2 in the LIHC tumor imm...

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Bibliographic Details
Main Authors: Yan Ouyang, Yan Gu, Xinhai Zhang, Ya Huang, Xianpeng Wei, Fuzhou Tang, Shichao Zhang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Cancer
Subjects:
AMPKα2
Cell communication
CD8+ T-cell exhaustion
Tumor immune escape
Immunotherapy
Liver hepatocellular carcinoma
Online Access:https://doi.org/10.1186/s12885-024-12025-y

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