Recent Advances in the Synthesis of Di- and Trisubstituted Hydroxylamines
As an underrepresented functional group in bioorganic and medicinal chemistry, the hydroxylamine unit has historically received little attention from the synthetic community. Recent developments, however, suggest that hydroxylamines may have broader applications such that a review covering recent de...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/6/2816 |
| _version_ | 1827748347932311552 |
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| author | Jarvis Hill Thomas D. Beckler David Crich |
| author_facet | Jarvis Hill Thomas D. Beckler David Crich |
| author_sort | Jarvis Hill |
| collection | DOAJ |
| description | As an underrepresented functional group in bioorganic and medicinal chemistry, the hydroxylamine unit has historically received little attention from the synthetic community. Recent developments, however, suggest that hydroxylamines may have broader applications such that a review covering recent developments in the synthesis of this functional group is timely. With this in mind, this review primarily covers developments in the past 15 years in the preparation of di- and trisubstituted hydroxylamines. The mechanism of the reactions and key features and shortcomings are discussed throughout the review. |
| first_indexed | 2024-03-11T06:07:11Z |
| format | Article |
| id | doaj.art-3e703d304efd40e8996fe93729f72048 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T06:07:11Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3e703d304efd40e8996fe93729f720482023-11-17T12:55:35ZengMDPI AGMolecules1420-30492023-03-01286281610.3390/molecules28062816Recent Advances in the Synthesis of Di- and Trisubstituted HydroxylaminesJarvis Hill0Thomas D. Beckler1David Crich2Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, GA 30602, USADepartment of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, GA 30602, USADepartment of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, GA 30602, USAAs an underrepresented functional group in bioorganic and medicinal chemistry, the hydroxylamine unit has historically received little attention from the synthetic community. Recent developments, however, suggest that hydroxylamines may have broader applications such that a review covering recent developments in the synthesis of this functional group is timely. With this in mind, this review primarily covers developments in the past 15 years in the preparation of di- and trisubstituted hydroxylamines. The mechanism of the reactions and key features and shortcomings are discussed throughout the review.https://www.mdpi.com/1420-3049/28/6/2816synthesishydroxylamineschemical reactionsamineschemical spaceheteroatoms |
| spellingShingle | Jarvis Hill Thomas D. Beckler David Crich Recent Advances in the Synthesis of Di- and Trisubstituted Hydroxylamines Molecules synthesis hydroxylamines chemical reactions amines chemical space heteroatoms |
| title | Recent Advances in the Synthesis of Di- and Trisubstituted Hydroxylamines |
| title_full | Recent Advances in the Synthesis of Di- and Trisubstituted Hydroxylamines |
| title_fullStr | Recent Advances in the Synthesis of Di- and Trisubstituted Hydroxylamines |
| title_full_unstemmed | Recent Advances in the Synthesis of Di- and Trisubstituted Hydroxylamines |
| title_short | Recent Advances in the Synthesis of Di- and Trisubstituted Hydroxylamines |
| title_sort | recent advances in the synthesis of di and trisubstituted hydroxylamines |
| topic | synthesis hydroxylamines chemical reactions amines chemical space heteroatoms |
| url | https://www.mdpi.com/1420-3049/28/6/2816 |
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