The fatal contribution of serine protease-related genetic variants to COVID-19 outcomes

The fatal contribution of serine protease-related genetic variants to COVID-19 outcomes

IntroductionSerine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 (TMPRSS2) and serpine family E member 1 (SERPINE1) could help to elucidate the contribution of variability to COVID-19 outcomes.MethodsTo evaluate the genetic va...

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Main Authors: Laura Edith Martínez-Gómez, Carlos Martinez-Armenta, Teresa Tusie-Luna, Paola Vázquez-Cárdenas, Rosa P. Vidal-Vázquez, Juan P. Ramírez-Hinojosa, Diana Gómez-Martín, Gilberto Vargas-Alarcón, Rosalinda Posadas-Sánchez, José Manuel Fragoso, Aurora de la Peña, José Manuel Rodríguez-Pérez, Mónica M. Mata-Miranda, Gustavo J. Vázquez-Zapién, Adriana Martínez-Cuazitl, Felipe de J. Martínez-Ruiz, Dulce M. Zayago-Angeles, Luis Ramos-Tavera, Alberto Méndez-Aguilera, María del C. Camacho-Rea, María L. Ordoñez-Sánchez, Yayoi Segura-Kato, Carlos Suarez-Ahedo, Jessel Olea-Torres, Brígida Herrera-López, Carlos Pineda, Gabriela A. Martínez-Nava, Alberto López-Reyes
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
COVID-19
SERPINE1
TMPRSS2
Polymorphism
SARS-CoV-2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1335963/full

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