Insecticidal efficacy of afoxolaner against Stomoxys calcitrans (Diptera: Muscidae) in dogs
The insecticidal activity of oral afoxolaner (NexGard®) against stable flies Stomoxys calcitrans (Diptera: Muscidae) that had fed on dogs was evaluated in a blinded, randomised, and negative controlled efficacy study. The efficacy assessments were based on survival rates of fed flies after challenge...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Current Research in Parasitology and Vector-Borne Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667114X21000376 |
| _version_ | 1831756823476043776 |
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| author | Eric Tielemans Nesrine Aouiche Adriaan Saunders J.F. Besselaar Frédéric Beugnet |
| author_facet | Eric Tielemans Nesrine Aouiche Adriaan Saunders J.F. Besselaar Frédéric Beugnet |
| author_sort | Eric Tielemans |
| collection | DOAJ |
| description | The insecticidal activity of oral afoxolaner (NexGard®) against stable flies Stomoxys calcitrans (Diptera: Muscidae) that had fed on dogs was evaluated in a blinded, randomised, and negative controlled efficacy study. The efficacy assessments were based on survival rates of fed flies after challenges to treated dogs. For a challenge, each dog was exposed to 50 unfed S. calcitrans for 30 minutes, after which time live fed flies were collected and incubated in an insectarium for viability assessment after 48, 72 and 96 hours. Fourteen dogs were randomly allocated to an untreated control group and an afoxolaner-treated group of seven dogs each. NexGard® was administered on Day 0 per label instructions to the treated group. All dogs were challenged on Days 1, 7, 14, 21 and 28. Efficacy was calculated by comparison of the proportion of incubated live fed flies for each individual after their related 30-min challenges in the control and treated groups after 48, 72 and 96 hours of incubation. A significant afoxolaner activity against S. calcitrans was demonstrated, with efficacy at 96 hours after blood-feeding ranging from 76.4 to 98.5% through Day 28. |
| first_indexed | 2024-12-22T00:19:47Z |
| format | Article |
| id | doaj.art-3e7173ef9db84600b0d4752b9d6afc98 |
| institution | Directory Open Access Journal |
| issn | 2667-114X |
| language | English |
| last_indexed | 2024-12-22T00:19:47Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Parasitology and Vector-Borne Diseases |
| spelling | doaj.art-3e7173ef9db84600b0d4752b9d6afc982022-12-21T18:45:11ZengElsevierCurrent Research in Parasitology and Vector-Borne Diseases2667-114X2021-01-011100043Insecticidal efficacy of afoxolaner against Stomoxys calcitrans (Diptera: Muscidae) in dogsEric Tielemans0Nesrine Aouiche1Adriaan Saunders2J.F. Besselaar3Frédéric Beugnet4Boehringer Ingelheim Animal Health, 29 Avenue Tony Garnier, 69007 Lyon, France; Corresponding author.Boehringer Ingelheim Animal Health, 29 Avenue Tony Garnier, 69007 Lyon, FranceClinvet International (Pty) Ltd, PO Box 11186, 9321 Universitas, South AfricaClindata International (Pty) Ltd, PO Box 11186, 9321 Universitas, South AfricaBoehringer Ingelheim Animal Health, 29 Avenue Tony Garnier, 69007 Lyon, FranceThe insecticidal activity of oral afoxolaner (NexGard®) against stable flies Stomoxys calcitrans (Diptera: Muscidae) that had fed on dogs was evaluated in a blinded, randomised, and negative controlled efficacy study. The efficacy assessments were based on survival rates of fed flies after challenges to treated dogs. For a challenge, each dog was exposed to 50 unfed S. calcitrans for 30 minutes, after which time live fed flies were collected and incubated in an insectarium for viability assessment after 48, 72 and 96 hours. Fourteen dogs were randomly allocated to an untreated control group and an afoxolaner-treated group of seven dogs each. NexGard® was administered on Day 0 per label instructions to the treated group. All dogs were challenged on Days 1, 7, 14, 21 and 28. Efficacy was calculated by comparison of the proportion of incubated live fed flies for each individual after their related 30-min challenges in the control and treated groups after 48, 72 and 96 hours of incubation. A significant afoxolaner activity against S. calcitrans was demonstrated, with efficacy at 96 hours after blood-feeding ranging from 76.4 to 98.5% through Day 28.http://www.sciencedirect.com/science/article/pii/S2667114X21000376AfoxolanerDogEfficacyStable flyStomoxys calcitrans |
| spellingShingle | Eric Tielemans Nesrine Aouiche Adriaan Saunders J.F. Besselaar Frédéric Beugnet Insecticidal efficacy of afoxolaner against Stomoxys calcitrans (Diptera: Muscidae) in dogs Current Research in Parasitology and Vector-Borne Diseases Afoxolaner Dog Efficacy Stable fly Stomoxys calcitrans |
| title | Insecticidal efficacy of afoxolaner against Stomoxys calcitrans (Diptera: Muscidae) in dogs |
| title_full | Insecticidal efficacy of afoxolaner against Stomoxys calcitrans (Diptera: Muscidae) in dogs |
| title_fullStr | Insecticidal efficacy of afoxolaner against Stomoxys calcitrans (Diptera: Muscidae) in dogs |
| title_full_unstemmed | Insecticidal efficacy of afoxolaner against Stomoxys calcitrans (Diptera: Muscidae) in dogs |
| title_short | Insecticidal efficacy of afoxolaner against Stomoxys calcitrans (Diptera: Muscidae) in dogs |
| title_sort | insecticidal efficacy of afoxolaner against stomoxys calcitrans diptera muscidae in dogs |
| topic | Afoxolaner Dog Efficacy Stable fly Stomoxys calcitrans |
| url | http://www.sciencedirect.com/science/article/pii/S2667114X21000376 |
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