Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice

Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice

Summary: Atherosclerotic cardiovascular disease is characterized by both chronic low-grade inflammation and dyslipidemia. The AMP-activated protein kinase (AMPK) inhibits cholesterol synthesis and dampens inflammation but whether pharmacological activation reduces atherosclerosis is equivocal. In th...

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Bibliographic Details
Main Authors: Emily A. Day, Logan K. Townsend, Sonia Rehal, Battsetseg Batchuluun, Dongdong Wang, Marisa R. Morrow, Rachel Lu, Lucie Lundenberg, Jessie H. Lu, Eric M. Desjardins, Tyler K.T. Smith, Amogelang R. Raphenya, Andrew G. McArthur, Morgan D. Fullerton, Gregory R. Steinberg
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:iScience
Subjects:
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223023465

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