In vitro anti-Helicobacter pylori activity and antivirulence activity of cetylpyridinium chloride.
The primary treatment method for eradicating Helicobacter pylori (H. pylori) infection involves the use of antibiotic-based therapies. Due to the growing antibiotic resistance of H. pylori, there has been a surge of interest in exploring alternative therapies. Cetylpyridinium chloride (CPC) is a wat...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0300696&type=printable |
| _version_ | 1797202030234697728 |
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| author | Mingjin Xun Zhong Feng Hui Li Meicun Yao Haibo Wang Ruixia Wei Junwei Jia Zimao Fan Xiaoyan Shi Zhanzhu Lv Guimin Zhang |
| author_facet | Mingjin Xun Zhong Feng Hui Li Meicun Yao Haibo Wang Ruixia Wei Junwei Jia Zimao Fan Xiaoyan Shi Zhanzhu Lv Guimin Zhang |
| author_sort | Mingjin Xun |
| collection | DOAJ |
| description | The primary treatment method for eradicating Helicobacter pylori (H. pylori) infection involves the use of antibiotic-based therapies. Due to the growing antibiotic resistance of H. pylori, there has been a surge of interest in exploring alternative therapies. Cetylpyridinium chloride (CPC) is a water-soluble and nonvolatile quaternary ammonium compound with exceptional broad-spectrum antibacterial properties. To date, there is no documented or described specific antibacterial action of CPC against H. pylori. Therefore, this study aimed to explore the in vitro activity of CPC against H. pylori and its potential antibacterial mechanism. CPC exhibited significant in vitro activity against H. pylori, with MICs ranging from 0.16 to 0.62 μg/mL and MBCs ranging from 0.31 to 1.24 μg/mL. CPC could result in morphological and physiological modifications in H. pylori, leading to the suppression of virulence and adherence genes expression, including flaA, flaB, babB, alpA, alpB, ureE, and ureF, and inhibition of urease activity. CPC has demonstrated in vitro activity against H. pylori by inhibiting its growth, inducing damage to the bacterial structure, reducing virulence and adherence factors expression, and inhibiting urease activity. |
| first_indexed | 2024-04-24T07:56:57Z |
| format | Article |
| id | doaj.art-3e732b6e2f1343e888ce1ba016a797d6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-24T07:56:57Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3e732b6e2f1343e888ce1ba016a797d62024-04-18T05:31:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01194e030069610.1371/journal.pone.0300696In vitro anti-Helicobacter pylori activity and antivirulence activity of cetylpyridinium chloride.Mingjin XunZhong FengHui LiMeicun YaoHaibo WangRuixia WeiJunwei JiaZimao FanXiaoyan ShiZhanzhu LvGuimin ZhangThe primary treatment method for eradicating Helicobacter pylori (H. pylori) infection involves the use of antibiotic-based therapies. Due to the growing antibiotic resistance of H. pylori, there has been a surge of interest in exploring alternative therapies. Cetylpyridinium chloride (CPC) is a water-soluble and nonvolatile quaternary ammonium compound with exceptional broad-spectrum antibacterial properties. To date, there is no documented or described specific antibacterial action of CPC against H. pylori. Therefore, this study aimed to explore the in vitro activity of CPC against H. pylori and its potential antibacterial mechanism. CPC exhibited significant in vitro activity against H. pylori, with MICs ranging from 0.16 to 0.62 μg/mL and MBCs ranging from 0.31 to 1.24 μg/mL. CPC could result in morphological and physiological modifications in H. pylori, leading to the suppression of virulence and adherence genes expression, including flaA, flaB, babB, alpA, alpB, ureE, and ureF, and inhibition of urease activity. CPC has demonstrated in vitro activity against H. pylori by inhibiting its growth, inducing damage to the bacterial structure, reducing virulence and adherence factors expression, and inhibiting urease activity.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0300696&type=printable |
| spellingShingle | Mingjin Xun Zhong Feng Hui Li Meicun Yao Haibo Wang Ruixia Wei Junwei Jia Zimao Fan Xiaoyan Shi Zhanzhu Lv Guimin Zhang In vitro anti-Helicobacter pylori activity and antivirulence activity of cetylpyridinium chloride. PLoS ONE |
| title | In vitro anti-Helicobacter pylori activity and antivirulence activity of cetylpyridinium chloride. |
| title_full | In vitro anti-Helicobacter pylori activity and antivirulence activity of cetylpyridinium chloride. |
| title_fullStr | In vitro anti-Helicobacter pylori activity and antivirulence activity of cetylpyridinium chloride. |
| title_full_unstemmed | In vitro anti-Helicobacter pylori activity and antivirulence activity of cetylpyridinium chloride. |
| title_short | In vitro anti-Helicobacter pylori activity and antivirulence activity of cetylpyridinium chloride. |
| title_sort | in vitro anti helicobacter pylori activity and antivirulence activity of cetylpyridinium chloride |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0300696&type=printable |
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