Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients
Abstract Background The impact of pre-existing comorbidities on acute pancreatitis (AP) mortality is not clearly defined. Our study aims to determine the trend in AP hospital mortality and the role of comorbidities as a predictor of hospital mortality. Methods We analyzed patients aged ≥ 18 years ho...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-023-02730-6 |
| _version_ | 1797859943055884288 |
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| author | Nils Jimmy Hidalgo Elizabeth Pando Rodrigo Mata Nair Fernandes Sara Villasante Marta Barros Daniel Herms Laia Blanco Joaquim Balsells Ramon Charco |
| author_facet | Nils Jimmy Hidalgo Elizabeth Pando Rodrigo Mata Nair Fernandes Sara Villasante Marta Barros Daniel Herms Laia Blanco Joaquim Balsells Ramon Charco |
| author_sort | Nils Jimmy Hidalgo |
| collection | DOAJ |
| description | Abstract Background The impact of pre-existing comorbidities on acute pancreatitis (AP) mortality is not clearly defined. Our study aims to determine the trend in AP hospital mortality and the role of comorbidities as a predictor of hospital mortality. Methods We analyzed patients aged ≥ 18 years hospitalized with AP diagnosis between 2016 and 2019. The data have been extracted from the Spanish National Hospital Discharge Database of the Spanish Ministry of Health. We performed a univariate and multivariable analysis of the association of age, sex, and comorbidities with hospital mortality in patients with AP. The role of the Charlson and Elixhauser comorbidity indices as predictors of mortality was evaluated. Results A total of 110,021 patients diagnosed with AP were hospitalized during the analyzed period. Hospital mortality was 3.8%, with a progressive decrease observed in the years evaluated. In multivariable analysis, age ≥ 65 years (OR: 4.11, p < 0.001), heart disease (OR: 1.73, p < 0.001), renal disease (OR: 1.99, p < 0.001), moderate-severe liver disease (OR: 2.86, p < 0.001), peripheral vascular disease (OR: 1.43, p < 0.001), and cerebrovascular disease (OR: 1.63, p < 0.001) were independent risk factors for mortality. The Charlson > 1.5 (OR: 2.03, p < 0.001) and Elixhauser > 1.5 (OR: 2.71, p < 0.001) comorbidity indices were also independently associated with mortality, and ROC curve analysis showed that they are useful for predicting hospital mortality. Conclusions Advanced age, heart disease, renal disease, moderate-severe liver disease, peripheral vascular disease, and cerebrovascular disease before admission were independently associated with hospital mortality. The Charlson and Elixhauser comorbidity indices are useful for predicting hospital mortality in AP patients. |
| first_indexed | 2024-04-09T21:37:44Z |
| format | Article |
| id | doaj.art-3e7ee0d18d8749c88e5c83bd794bac21 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-04-09T21:37:44Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-3e7ee0d18d8749c88e5c83bd794bac212023-03-26T11:12:20ZengBMCBMC Gastroenterology1471-230X2023-03-0123111010.1186/s12876-023-02730-6Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patientsNils Jimmy Hidalgo0Elizabeth Pando1Rodrigo Mata2Nair Fernandes3Sara Villasante4Marta Barros5Daniel Herms6Laia Blanco7Joaquim Balsells8Ramon Charco9Universitat Autonoma de BarcelonaUniversitat Autonoma de BarcelonaDepartment of Hepato-Pancreato-Biliary and Transplant Surgery, Hospital Universitari Vall d’HebronDepartment of Hepato-Pancreato-Biliary and Transplant Surgery, Hospital Universitari Vall d’HebronDepartment of Hepato-Pancreato-Biliary and Transplant Surgery, Hospital Universitari Vall d’HebronDepartment of Hepato-Pancreato-Biliary and Transplant Surgery, Hospital Universitari Vall d’HebronDepartment of Hepato-Pancreato-Biliary and Transplant Surgery, Hospital Universitari Vall d’HebronDepartment of Hepato-Pancreato-Biliary and Transplant Surgery, Hospital Universitari Vall d’HebronDepartment of Hepato-Pancreato-Biliary and Transplant Surgery, Hospital Universitari Vall d’HebronDepartment of Hepato-Pancreato-Biliary and Transplant Surgery, Hospital Universitari Vall d’HebronAbstract Background The impact of pre-existing comorbidities on acute pancreatitis (AP) mortality is not clearly defined. Our study aims to determine the trend in AP hospital mortality and the role of comorbidities as a predictor of hospital mortality. Methods We analyzed patients aged ≥ 18 years hospitalized with AP diagnosis between 2016 and 2019. The data have been extracted from the Spanish National Hospital Discharge Database of the Spanish Ministry of Health. We performed a univariate and multivariable analysis of the association of age, sex, and comorbidities with hospital mortality in patients with AP. The role of the Charlson and Elixhauser comorbidity indices as predictors of mortality was evaluated. Results A total of 110,021 patients diagnosed with AP were hospitalized during the analyzed period. Hospital mortality was 3.8%, with a progressive decrease observed in the years evaluated. In multivariable analysis, age ≥ 65 years (OR: 4.11, p < 0.001), heart disease (OR: 1.73, p < 0.001), renal disease (OR: 1.99, p < 0.001), moderate-severe liver disease (OR: 2.86, p < 0.001), peripheral vascular disease (OR: 1.43, p < 0.001), and cerebrovascular disease (OR: 1.63, p < 0.001) were independent risk factors for mortality. The Charlson > 1.5 (OR: 2.03, p < 0.001) and Elixhauser > 1.5 (OR: 2.71, p < 0.001) comorbidity indices were also independently associated with mortality, and ROC curve analysis showed that they are useful for predicting hospital mortality. Conclusions Advanced age, heart disease, renal disease, moderate-severe liver disease, peripheral vascular disease, and cerebrovascular disease before admission were independently associated with hospital mortality. The Charlson and Elixhauser comorbidity indices are useful for predicting hospital mortality in AP patients.https://doi.org/10.1186/s12876-023-02730-6Acute pancreatitisHospital mortalityComorbidityCharlson indexElixhauser index |
| spellingShingle | Nils Jimmy Hidalgo Elizabeth Pando Rodrigo Mata Nair Fernandes Sara Villasante Marta Barros Daniel Herms Laia Blanco Joaquim Balsells Ramon Charco Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients BMC Gastroenterology Acute pancreatitis Hospital mortality Comorbidity Charlson index Elixhauser index |
| title | Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients |
| title_full | Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients |
| title_fullStr | Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients |
| title_full_unstemmed | Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients |
| title_short | Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients |
| title_sort | impact of comorbidities on hospital mortality in patients with acute pancreatitis a population based study of 110 021 patients |
| topic | Acute pancreatitis Hospital mortality Comorbidity Charlson index Elixhauser index |
| url | https://doi.org/10.1186/s12876-023-02730-6 |
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