Non-Coding RNA as Biomarkers for Type 2 Diabetes Development and Clinical Management
Diabetes, a metabolic disease characterized by high blood glucose and other complications, has undefined causes and multiple risk factors, including inappropriate diet, unhealthy lifestyles, and genetic predisposition. The two most distinguished types of diabetes are type 1 and type 2 diabetes, resu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.630032/full |
| _version_ | 1818721455815262208 |
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| author | Tiange Chi Tiange Chi Jiaran Lin Jiaran Lin Mina Wang Mina Wang Yihan Zhao Zehuan Liao Zehuan Liao Peng Wei |
| author_facet | Tiange Chi Tiange Chi Jiaran Lin Jiaran Lin Mina Wang Mina Wang Yihan Zhao Zehuan Liao Zehuan Liao Peng Wei |
| author_sort | Tiange Chi |
| collection | DOAJ |
| description | Diabetes, a metabolic disease characterized by high blood glucose and other complications, has undefined causes and multiple risk factors, including inappropriate diet, unhealthy lifestyles, and genetic predisposition. The two most distinguished types of diabetes are type 1 and type 2 diabetes, resulting from the autoimmune impairment of insulin-generating pancreatic β cells and insulin insensitivity, respectively. Non-coding RNAs (ncRNAs), a cohort of RNAs with little transcriptional value, have been found to exert substantial importance in epigenetic and posttranscriptional modulation of gene expression such as messenger RNA (mRNA) silencing. This review mainly focuses on the pathology of type 2 diabetes (T2D) and ncRNAs as potential biomarkers in T2D development and clinical management. We consolidate the pathogenesis, diagnosis, and current treatments of T2D, and present the existing evidence on changes in multiple types of ncRNAs in response to various pathological changes and dysfunctions in different stages of T2D. |
| first_indexed | 2024-12-17T20:39:01Z |
| format | Article |
| id | doaj.art-3e7f1c9a770144848deb740d43038e81 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-17T20:39:01Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-3e7f1c9a770144848deb740d43038e812022-12-21T21:33:22ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-09-011210.3389/fendo.2021.630032630032Non-Coding RNA as Biomarkers for Type 2 Diabetes Development and Clinical ManagementTiange Chi0Tiange Chi1Jiaran Lin2Jiaran Lin3Mina Wang4Mina Wang5Yihan Zhao6Zehuan Liao7Zehuan Liao8Peng Wei9School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaFirst Clinical Medical College, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Nephrology and Endocrinology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Biological Sciences, Nanyang Technological University, Singapore, SingaporeDepartment of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, SwedenSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaDiabetes, a metabolic disease characterized by high blood glucose and other complications, has undefined causes and multiple risk factors, including inappropriate diet, unhealthy lifestyles, and genetic predisposition. The two most distinguished types of diabetes are type 1 and type 2 diabetes, resulting from the autoimmune impairment of insulin-generating pancreatic β cells and insulin insensitivity, respectively. Non-coding RNAs (ncRNAs), a cohort of RNAs with little transcriptional value, have been found to exert substantial importance in epigenetic and posttranscriptional modulation of gene expression such as messenger RNA (mRNA) silencing. This review mainly focuses on the pathology of type 2 diabetes (T2D) and ncRNAs as potential biomarkers in T2D development and clinical management. We consolidate the pathogenesis, diagnosis, and current treatments of T2D, and present the existing evidence on changes in multiple types of ncRNAs in response to various pathological changes and dysfunctions in different stages of T2D.https://www.frontiersin.org/articles/10.3389/fendo.2021.630032/fullncRNAsmiRNAslncRNAscircRNAsdiabetesbiomarker |
| spellingShingle | Tiange Chi Tiange Chi Jiaran Lin Jiaran Lin Mina Wang Mina Wang Yihan Zhao Zehuan Liao Zehuan Liao Peng Wei Non-Coding RNA as Biomarkers for Type 2 Diabetes Development and Clinical Management Frontiers in Endocrinology ncRNAs miRNAs lncRNAs circRNAs diabetes biomarker |
| title | Non-Coding RNA as Biomarkers for Type 2 Diabetes Development and Clinical Management |
| title_full | Non-Coding RNA as Biomarkers for Type 2 Diabetes Development and Clinical Management |
| title_fullStr | Non-Coding RNA as Biomarkers for Type 2 Diabetes Development and Clinical Management |
| title_full_unstemmed | Non-Coding RNA as Biomarkers for Type 2 Diabetes Development and Clinical Management |
| title_short | Non-Coding RNA as Biomarkers for Type 2 Diabetes Development and Clinical Management |
| title_sort | non coding rna as biomarkers for type 2 diabetes development and clinical management |
| topic | ncRNAs miRNAs lncRNAs circRNAs diabetes biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.630032/full |
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