Resistance training restores skeletal muscle atrophy and satellite cell content in an animal model of Alzheimer’s disease
Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disease, and numerous recent findings suggest that several pathologic signs, including loss of muscle strength and mass, are also detected in these patients. In the present study, we evaluated muscle cross-sectional area (CSA), m...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-29406-1 |
| _version_ | 1797864792452497408 |
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| author | Masoud Rahmati Mohammad Shariatzadeh Joneydi Ai Koyanagi Guang Yang Bingzhou Ji Seung Won Lee Dong Keon Yon Lee Smith Jae Il Shin Yusheng Li |
| author_facet | Masoud Rahmati Mohammad Shariatzadeh Joneydi Ai Koyanagi Guang Yang Bingzhou Ji Seung Won Lee Dong Keon Yon Lee Smith Jae Il Shin Yusheng Li |
| author_sort | Masoud Rahmati |
| collection | DOAJ |
| description | Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disease, and numerous recent findings suggest that several pathologic signs, including loss of muscle strength and mass, are also detected in these patients. In the present study, we evaluated muscle cross-sectional area (CSA), myonuclear number, satellite cell (SC) content, and myosin heavy chain (MyHC) types in an animal model of AD and examined the possible role of resistance training in controlling skeletal muscle size in this disease. Fifty-eight male rats were randomly divided into four groups: healthy-control (H-C), healthy-exercise (H-Ex), Alzheimer-control (A-C), and Alzheimer-exercise (A-Ex). AD was induced by the single injection of 1–42 amyloid into the CA1 region of the hippocampus (1 μl/site). The rats in H-Ex and A-Ex groups performed a 5-week resistance training period (17 sessions). The results indicated that AD induces significant skeletal muscle atrophy and reduces the myonuclear number and SC content in gastrocnemius muscle in both whole muscle cross-sections and isolated myofibers. Interestingly, we did not find any significant differences in the different MyHC distributions of AD animals compared with controls, while resistance training significantly increased the CSA of MyHC IIb fibers in both AD and healthy animals. Altogether, these observations suggest that the skeletal muscle of AD animals are more prone to atrophy and loss of myonuclear number and satellite cell content, while resistance training successfully restores these impairments. |
| first_indexed | 2024-04-09T22:58:12Z |
| format | Article |
| id | doaj.art-3e822f09829d4fbaad1739b91e5bfc2b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T22:58:12Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-3e822f09829d4fbaad1739b91e5bfc2b2023-03-22T11:08:25ZengNature PortfolioScientific Reports2045-23222023-02-0113111010.1038/s41598-023-29406-1Resistance training restores skeletal muscle atrophy and satellite cell content in an animal model of Alzheimer’s diseaseMasoud Rahmati0Mohammad Shariatzadeh Joneydi1Ai Koyanagi2Guang Yang3Bingzhou Ji4Seung Won Lee5Dong Keon Yon6Lee Smith7Jae Il Shin8Yusheng Li9Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan UniversitySport Sciences Research Institute of IranParc Sanitari Sant Joan de Deu/CIBERSAM, ISCIII, Universitat de Barcelona, Fundacio Sant Joan de DeuDeparment of Orthopedics, Xiangya Hospital, Central South UniversityDeparment of Orthopedics, Xiangya Hospital, Central South UniversitySungkyunkwan University School of MedicineMedical Science Research Institute, Kyung Hee University College of MedicineCentre for Health, Performance, and Wellbeing, Anglia Ruskin UniversityDepartment of Pediatrics, Yonsei University College of MedicineDeparment of Orthopedics, Xiangya Hospital, Central South UniversityAbstract Alzheimer’s disease (AD) is the most common neurodegenerative disease, and numerous recent findings suggest that several pathologic signs, including loss of muscle strength and mass, are also detected in these patients. In the present study, we evaluated muscle cross-sectional area (CSA), myonuclear number, satellite cell (SC) content, and myosin heavy chain (MyHC) types in an animal model of AD and examined the possible role of resistance training in controlling skeletal muscle size in this disease. Fifty-eight male rats were randomly divided into four groups: healthy-control (H-C), healthy-exercise (H-Ex), Alzheimer-control (A-C), and Alzheimer-exercise (A-Ex). AD was induced by the single injection of 1–42 amyloid into the CA1 region of the hippocampus (1 μl/site). The rats in H-Ex and A-Ex groups performed a 5-week resistance training period (17 sessions). The results indicated that AD induces significant skeletal muscle atrophy and reduces the myonuclear number and SC content in gastrocnemius muscle in both whole muscle cross-sections and isolated myofibers. Interestingly, we did not find any significant differences in the different MyHC distributions of AD animals compared with controls, while resistance training significantly increased the CSA of MyHC IIb fibers in both AD and healthy animals. Altogether, these observations suggest that the skeletal muscle of AD animals are more prone to atrophy and loss of myonuclear number and satellite cell content, while resistance training successfully restores these impairments.https://doi.org/10.1038/s41598-023-29406-1 |
| spellingShingle | Masoud Rahmati Mohammad Shariatzadeh Joneydi Ai Koyanagi Guang Yang Bingzhou Ji Seung Won Lee Dong Keon Yon Lee Smith Jae Il Shin Yusheng Li Resistance training restores skeletal muscle atrophy and satellite cell content in an animal model of Alzheimer’s disease Scientific Reports |
| title | Resistance training restores skeletal muscle atrophy and satellite cell content in an animal model of Alzheimer’s disease |
| title_full | Resistance training restores skeletal muscle atrophy and satellite cell content in an animal model of Alzheimer’s disease |
| title_fullStr | Resistance training restores skeletal muscle atrophy and satellite cell content in an animal model of Alzheimer’s disease |
| title_full_unstemmed | Resistance training restores skeletal muscle atrophy and satellite cell content in an animal model of Alzheimer’s disease |
| title_short | Resistance training restores skeletal muscle atrophy and satellite cell content in an animal model of Alzheimer’s disease |
| title_sort | resistance training restores skeletal muscle atrophy and satellite cell content in an animal model of alzheimer s disease |
| url | https://doi.org/10.1038/s41598-023-29406-1 |
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