Monitoring Mosquito-Borne Arbovirus in Various Insect Regions in China in 2018
BackgroundIncreases in global travel and trade are changing arbovirus distributions worldwide. Arboviruses can be introduced by travelers, migratory birds, or vectors transported via international trade. Arbovirus surveillance in field-collected mosquitoes may provide early evidence for mosquito-bor...
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| Format: | Article |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.640993/full |
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| author | Yuan Fang Yuan Fang Yuan Fang Yuan Fang Yuan Fang Wei Zhang Jing-Bo Xue Jing-Bo Xue Jing-Bo Xue Jing-Bo Xue Jing-Bo Xue Yi Zhang Yi Zhang Yi Zhang Yi Zhang Yi Zhang |
| author_facet | Yuan Fang Yuan Fang Yuan Fang Yuan Fang Yuan Fang Wei Zhang Jing-Bo Xue Jing-Bo Xue Jing-Bo Xue Jing-Bo Xue Jing-Bo Xue Yi Zhang Yi Zhang Yi Zhang Yi Zhang Yi Zhang |
| author_sort | Yuan Fang |
| collection | DOAJ |
| description | BackgroundIncreases in global travel and trade are changing arbovirus distributions worldwide. Arboviruses can be introduced by travelers, migratory birds, or vectors transported via international trade. Arbovirus surveillance in field-collected mosquitoes may provide early evidence for mosquito-borne disease transmission.MethodsDuring the seasons of high mosquito activity of 2018, 29,285 mosquitoes were sampled from seven sentinel sites in various insect regions. The mosquitoes were analyzed by RT-PCR for alphaviruses, flaviviruses, and orthobunyaviruses.ResultsWe detected three strains of Japanese encephalitis virus (JEV), five strains of Getah virus (GETV), and 45 strains of insect-specific flaviviruses including Aedes flavivirus (AeFV, 1), Chaoyang virus (CHAOV, 1), Culex flavivirus (CxFV, 17), Hanko virus (HANKV, 2), QuangBinh virus (QBV, 22), and Yunnan Culex flavivirus (YNCxFV, 2). Whole genomes of one strain each of GETV, CxFV, CHAOV, and AeFV were successfully amplified. Phylogenetic analysis revealed that the new JEV strains detected in the Shanghai and Hubei Provinces belong to the GI-b strain and are phylogenetically close to the NX1889 strain (MT134112) isolated from a patient during a JE outbreak in Ningxia in 2018. GETVs were found in Inner Mongolia, Hubei, and Hainan and belonged to Group III. They were closely related to strains isolated from swine. HANKV was recorded for the first time in China and other ISFVs were newly detected at several sentinel sites. The bias-corrected maximum likelihood estimation value for JEV in Jinshan, Shanghai was 4.52/1,000 (range 0.80–14.64). Hence, there is a potential risk of a JEV epidemic in that region.ConclusionGI-b is the dominant circulating JEV genotype in nature and poses a health risk to animals and humans. The potential threat of widespread GETV distribution as a zoonosis is gradually increasing. The present study also disclosed the dispersion and host range of ISFVs. These findings highlight the importance of tracing the movements of the vectors and hosts of mosquito-borne pathogens in order to prevent and control arbovirus outbreaks in China. |
| first_indexed | 2024-12-22T11:32:19Z |
| format | Article |
| id | doaj.art-3e83a8747f374bac9f921889aaaa332f |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-22T11:32:19Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-3e83a8747f374bac9f921889aaaa332f2022-12-21T18:27:34ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-03-011110.3389/fcimb.2021.640993640993Monitoring Mosquito-Borne Arbovirus in Various Insect Regions in China in 2018Yuan Fang0Yuan Fang1Yuan Fang2Yuan Fang3Yuan Fang4Wei Zhang5Jing-Bo Xue6Jing-Bo Xue7Jing-Bo Xue8Jing-Bo Xue9Jing-Bo Xue10Yi Zhang11Yi Zhang12Yi Zhang13Yi Zhang14Yi Zhang15National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, ChinaChinese Center for Tropical Diseases Research, Ministry of Science and Technology, Shanghai, ChinaKey Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, ChinaWHO Collaborating Centre for Tropical Diseases, Shanghai, ChinaNational Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, ChinaZichuan District Center for Disease Control and Prevention, Zibo, ChinaNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, ChinaChinese Center for Tropical Diseases Research, Ministry of Science and Technology, Shanghai, ChinaKey Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, ChinaWHO Collaborating Centre for Tropical Diseases, Shanghai, ChinaNational Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, ChinaNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, ChinaChinese Center for Tropical Diseases Research, Ministry of Science and Technology, Shanghai, ChinaKey Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, ChinaWHO Collaborating Centre for Tropical Diseases, Shanghai, ChinaNational Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, ChinaBackgroundIncreases in global travel and trade are changing arbovirus distributions worldwide. Arboviruses can be introduced by travelers, migratory birds, or vectors transported via international trade. Arbovirus surveillance in field-collected mosquitoes may provide early evidence for mosquito-borne disease transmission.MethodsDuring the seasons of high mosquito activity of 2018, 29,285 mosquitoes were sampled from seven sentinel sites in various insect regions. The mosquitoes were analyzed by RT-PCR for alphaviruses, flaviviruses, and orthobunyaviruses.ResultsWe detected three strains of Japanese encephalitis virus (JEV), five strains of Getah virus (GETV), and 45 strains of insect-specific flaviviruses including Aedes flavivirus (AeFV, 1), Chaoyang virus (CHAOV, 1), Culex flavivirus (CxFV, 17), Hanko virus (HANKV, 2), QuangBinh virus (QBV, 22), and Yunnan Culex flavivirus (YNCxFV, 2). Whole genomes of one strain each of GETV, CxFV, CHAOV, and AeFV were successfully amplified. Phylogenetic analysis revealed that the new JEV strains detected in the Shanghai and Hubei Provinces belong to the GI-b strain and are phylogenetically close to the NX1889 strain (MT134112) isolated from a patient during a JE outbreak in Ningxia in 2018. GETVs were found in Inner Mongolia, Hubei, and Hainan and belonged to Group III. They were closely related to strains isolated from swine. HANKV was recorded for the first time in China and other ISFVs were newly detected at several sentinel sites. The bias-corrected maximum likelihood estimation value for JEV in Jinshan, Shanghai was 4.52/1,000 (range 0.80–14.64). Hence, there is a potential risk of a JEV epidemic in that region.ConclusionGI-b is the dominant circulating JEV genotype in nature and poses a health risk to animals and humans. The potential threat of widespread GETV distribution as a zoonosis is gradually increasing. The present study also disclosed the dispersion and host range of ISFVs. These findings highlight the importance of tracing the movements of the vectors and hosts of mosquito-borne pathogens in order to prevent and control arbovirus outbreaks in China.https://www.frontiersin.org/articles/10.3389/fcimb.2021.640993/fullJapanese encephalitis virusGetah virusinsect-specific flavivirusCulexAnopheles |
| spellingShingle | Yuan Fang Yuan Fang Yuan Fang Yuan Fang Yuan Fang Wei Zhang Jing-Bo Xue Jing-Bo Xue Jing-Bo Xue Jing-Bo Xue Jing-Bo Xue Yi Zhang Yi Zhang Yi Zhang Yi Zhang Yi Zhang Monitoring Mosquito-Borne Arbovirus in Various Insect Regions in China in 2018 Frontiers in Cellular and Infection Microbiology Japanese encephalitis virus Getah virus insect-specific flavivirus Culex Anopheles |
| title | Monitoring Mosquito-Borne Arbovirus in Various Insect Regions in China in 2018 |
| title_full | Monitoring Mosquito-Borne Arbovirus in Various Insect Regions in China in 2018 |
| title_fullStr | Monitoring Mosquito-Borne Arbovirus in Various Insect Regions in China in 2018 |
| title_full_unstemmed | Monitoring Mosquito-Borne Arbovirus in Various Insect Regions in China in 2018 |
| title_short | Monitoring Mosquito-Borne Arbovirus in Various Insect Regions in China in 2018 |
| title_sort | monitoring mosquito borne arbovirus in various insect regions in china in 2018 |
| topic | Japanese encephalitis virus Getah virus insect-specific flavivirus Culex Anopheles |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.640993/full |
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