CD4 Donor Lymphocyte Infusion Can Cause Conversion of Chimerism Without GVHD by Inducing Immune Responses Targeting Minor Histocompatibility Antigens in HLA Class II

CD4 Donor Lymphocyte Infusion Can Cause Conversion of Chimerism Without GVHD by Inducing Immune Responses Targeting Minor Histocompatibility Antigens in HLA Class II

Under non-inflammatory conditions HLA class II is predominantly expressed on hematopoietic cells. Therefore, donor CD4 T-cells after allogeneic stem cell transplantation (alloSCT) may mediate graft-vs.-leukemia reactivity without graft-vs.-host disease (GVHD). We analyzed immune responses in four pa...

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Bibliographic Details
Main Authors: Peter van Balen, Cornelis A. M. van Bergen, Simone A. P. van Luxemburg-Heijs, Wendy de Klerk, Esther H. M. van Egmond, Sabrina A. J. Veld, Constantijn J. M. Halkes, Jaap-Jan Zwaginga, Marieke Griffioen, Inge Jedema, J. H. Frederik Falkenburg
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
HLA class II
CD4 donor lymphocyte infusion
minor histocompatibility antigen
allogeneic stem cell transplantation
graft-vs.-tumor reactivity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03016/full

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