Research and development of new tuberculosis vaccines: a review [version 1; referees: 2 approved, 1 approved with reservations]
Tuberculosis kills more people worldwide than any other single infectious disease agent, a threat made more dire by the spread of drug-resistant strains of Mycobacterium tuberculosis (Mtb). Development of new vaccines capable of preventing TB disease and new Mtb infection are an essential component...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2018-11-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/7-1732/v1 |
| _version_ | 1828495026342068224 |
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| author | Lewis K. Schrager Rebecca C. Harris Johan Vekemans |
| author_facet | Lewis K. Schrager Rebecca C. Harris Johan Vekemans |
| author_sort | Lewis K. Schrager |
| collection | DOAJ |
| description | Tuberculosis kills more people worldwide than any other single infectious disease agent, a threat made more dire by the spread of drug-resistant strains of Mycobacterium tuberculosis (Mtb). Development of new vaccines capable of preventing TB disease and new Mtb infection are an essential component of the strategy to combat the TB epidemic. Accordingly, the WHO considers the development of new TB vaccines a major public health priority. In October 2017, the WHO convened a consultation with global leaders in the TB vaccine development field to emphasize the WHO commitment to this effort and to facilitate creative approaches to the discovery and development of TB vaccine candidates. This review summarizes the presentations at this consultation, updated with scientific literature references, and includes discussions of the public health need for a TB vaccine; the status of efforts to develop vaccines to replace or potentiate BCG in infants and develop new TB vaccines for adolescents and adults; strategies being employed to diversify vaccine platforms; and new animal models being developed to facilitate TB vaccine development. A perspective on the status of these efforts from the major funders and organizational contributors also is included. This presentation highlights the extraordinary progress being made to develop new TB vaccines and provided a clear picture of the exciting development pathways that are being explored. |
| first_indexed | 2024-12-11T12:05:57Z |
| format | Article |
| id | doaj.art-3e863367a280496e859aeebb1b6f42a3 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-11T12:05:57Z |
| publishDate | 2018-11-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-3e863367a280496e859aeebb1b6f42a32022-12-22T01:07:56ZengF1000 Research LtdF1000Research2046-14022018-11-01710.12688/f1000research.16521.118057Research and development of new tuberculosis vaccines: a review [version 1; referees: 2 approved, 1 approved with reservations]Lewis K. Schrager0Rebecca C. Harris1Johan Vekemans2Consultant, World Health Organization, Geneva, SwitzerlandLondon School of Hygiene & Tropical Medicine, London, UKInitiative for Vaccine Research, World Health Organization, Geneva, SwitzerlandTuberculosis kills more people worldwide than any other single infectious disease agent, a threat made more dire by the spread of drug-resistant strains of Mycobacterium tuberculosis (Mtb). Development of new vaccines capable of preventing TB disease and new Mtb infection are an essential component of the strategy to combat the TB epidemic. Accordingly, the WHO considers the development of new TB vaccines a major public health priority. In October 2017, the WHO convened a consultation with global leaders in the TB vaccine development field to emphasize the WHO commitment to this effort and to facilitate creative approaches to the discovery and development of TB vaccine candidates. This review summarizes the presentations at this consultation, updated with scientific literature references, and includes discussions of the public health need for a TB vaccine; the status of efforts to develop vaccines to replace or potentiate BCG in infants and develop new TB vaccines for adolescents and adults; strategies being employed to diversify vaccine platforms; and new animal models being developed to facilitate TB vaccine development. A perspective on the status of these efforts from the major funders and organizational contributors also is included. This presentation highlights the extraordinary progress being made to develop new TB vaccines and provided a clear picture of the exciting development pathways that are being explored.https://f1000research.com/articles/7-1732/v1 |
| spellingShingle | Lewis K. Schrager Rebecca C. Harris Johan Vekemans Research and development of new tuberculosis vaccines: a review [version 1; referees: 2 approved, 1 approved with reservations] F1000Research |
| title | Research and development of new tuberculosis vaccines: a review [version 1; referees: 2 approved, 1 approved with reservations] |
| title_full | Research and development of new tuberculosis vaccines: a review [version 1; referees: 2 approved, 1 approved with reservations] |
| title_fullStr | Research and development of new tuberculosis vaccines: a review [version 1; referees: 2 approved, 1 approved with reservations] |
| title_full_unstemmed | Research and development of new tuberculosis vaccines: a review [version 1; referees: 2 approved, 1 approved with reservations] |
| title_short | Research and development of new tuberculosis vaccines: a review [version 1; referees: 2 approved, 1 approved with reservations] |
| title_sort | research and development of new tuberculosis vaccines a review version 1 referees 2 approved 1 approved with reservations |
| url | https://f1000research.com/articles/7-1732/v1 |
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