Investigating the effect of intraperitoneal administration of zinc oxide nanoparticles on the model of postpartum depression in adult female mice
Background & Objective: Postpartum depression appears to be a harmful condition affecting mothers and their babies negatively. Regarding their side effects, the tendency to use antidepressants has especially fallen in nursing mothers. Considering the effect of zinc on mood, this study was conduc...
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2018-04-01
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| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-1463-en.pdf |
| _version_ | 1797679616203161600 |
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| author | Sahar Fadaei Saeid Valipour Chahardahcharic Hosein Sazgar |
| author_facet | Sahar Fadaei Saeid Valipour Chahardahcharic Hosein Sazgar |
| author_sort | Sahar Fadaei |
| collection | DOAJ |
| description | Background & Objective: Postpartum depression appears to be a harmful condition affecting mothers and their babies negatively. Regarding their side effects, the tendency to use antidepressants has especially fallen in nursing mothers. Considering the effect of zinc on mood, this study was conducted to determine the efficacy of zinc oxide nanoparticles on postpartum depression in female mice.
Material & Methods: In this experimental study, the adult female mice of NMARI breed (25-30gr) were divided into six groups respectively (n=8): 1) Control 2) Depressed group 3, 4, 5) Depressed groups treated with a dose of zinc oxide nanoparticles including (5, 10 and 20 mg/kg) 6) Depressed groups treated for 8 days with a dose of 5 mg/kg zinc oxide nanoparticles.
First, the studied animals were depressed by intraperitoneal injection of 5mg/kg progesterone for 5 days. The control group received no drug or solvent. The assessment of depression rate on the eighth day after the start of administration of progesterone was conducted by forced swim test.
Results: The zinc oxide nanoparticles at doses 10 mg/kg (P< 0.01) and 20 mg/kg (P< 0.05) and also at 5 mg/kg dose for 8 days (P< 0.01) led to a significant decrease in immobilization time in depressed mice.
Conclusion: Administration of progesterone induces depression, and thus, increases the period of immobilization of mice. The zinc oxide nanoparticles reduced the symptom of postpartum depression in forced swim test. The findings can be used to show the effects of zinc oxide nanoparticles in the reduction of postpartum depression. |
| first_indexed | 2024-03-11T23:17:22Z |
| format | Article |
| id | doaj.art-3e87ab0ed09d4e23a8272ec208a92c6f |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:17:22Z |
| publishDate | 2018-04-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-3e87ab0ed09d4e23a8272ec208a92c6f2023-09-20T21:23:49ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232018-04-0181666673Investigating the effect of intraperitoneal administration of zinc oxide nanoparticles on the model of postpartum depression in adult female miceSahar Fadaei0Saeid Valipour Chahardahcharic1Hosein Sazgar2 Department of Biology, Faculty of Sciences, Shahre Kord Branch, Islamic Azad University, Shahre Kord, Iran Department of Biology, Faculty of Sciences, Izeh Branch, Islamic Azad University, Izeh, Iran Department of Biology, Faculty of Sciences, Shahre Kord Branch, Islamic Azad University, Shahre Kord, Iran Background & Objective: Postpartum depression appears to be a harmful condition affecting mothers and their babies negatively. Regarding their side effects, the tendency to use antidepressants has especially fallen in nursing mothers. Considering the effect of zinc on mood, this study was conducted to determine the efficacy of zinc oxide nanoparticles on postpartum depression in female mice. Material & Methods: In this experimental study, the adult female mice of NMARI breed (25-30gr) were divided into six groups respectively (n=8): 1) Control 2) Depressed group 3, 4, 5) Depressed groups treated with a dose of zinc oxide nanoparticles including (5, 10 and 20 mg/kg) 6) Depressed groups treated for 8 days with a dose of 5 mg/kg zinc oxide nanoparticles. First, the studied animals were depressed by intraperitoneal injection of 5mg/kg progesterone for 5 days. The control group received no drug or solvent. The assessment of depression rate on the eighth day after the start of administration of progesterone was conducted by forced swim test. Results: The zinc oxide nanoparticles at doses 10 mg/kg (P< 0.01) and 20 mg/kg (P< 0.05) and also at 5 mg/kg dose for 8 days (P< 0.01) led to a significant decrease in immobilization time in depressed mice. Conclusion: Administration of progesterone induces depression, and thus, increases the period of immobilization of mice. The zinc oxide nanoparticles reduced the symptom of postpartum depression in forced swim test. The findings can be used to show the effects of zinc oxide nanoparticles in the reduction of postpartum depression.http://jabs.fums.ac.ir/article-1-1463-en.pdfpostpartum depressionzinc oxide nanoparticlesprogesteronemice |
| spellingShingle | Sahar Fadaei Saeid Valipour Chahardahcharic Hosein Sazgar Investigating the effect of intraperitoneal administration of zinc oxide nanoparticles on the model of postpartum depression in adult female mice Journal of Advanced Biomedical Sciences postpartum depression zinc oxide nanoparticles progesterone mice |
| title | Investigating the effect of intraperitoneal administration of zinc oxide nanoparticles on the model of postpartum depression in adult female mice |
| title_full | Investigating the effect of intraperitoneal administration of zinc oxide nanoparticles on the model of postpartum depression in adult female mice |
| title_fullStr | Investigating the effect of intraperitoneal administration of zinc oxide nanoparticles on the model of postpartum depression in adult female mice |
| title_full_unstemmed | Investigating the effect of intraperitoneal administration of zinc oxide nanoparticles on the model of postpartum depression in adult female mice |
| title_short | Investigating the effect of intraperitoneal administration of zinc oxide nanoparticles on the model of postpartum depression in adult female mice |
| title_sort | investigating the effect of intraperitoneal administration of zinc oxide nanoparticles on the model of postpartum depression in adult female mice |
| topic | postpartum depression zinc oxide nanoparticles progesterone mice |
| url | http://jabs.fums.ac.ir/article-1-1463-en.pdf |
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